HPMC kunyango lwezilwanyana

IHydroxypropyl methylcellulose (HPMC) yipolima esetyenziswa kakhulu kwishishini loxubo-mayeza, kwaye ikwasetyenziswa ekulungiseleleni amayeza ezilwanyana.I-HPMC yi-ether eselulosi enyibilikayo emanzini, engeyoyo-ionic ephuma kwiselulosi yendalo.Yipolymer ekhuselekileyo, ehambelanayo, kunye ne-biodegradable esetyenziselwa ukuphucula uzinzo, iimpawu ze-rheological, kunye ne-bioavailability yamayeza ezilwanyana.Kweli nqaku, siza kuxubusha iipropati kunye nokusetyenziswa kwe-HPMC kunyango lwezilwanyana.

Iipropati ze-HPMC

I-HPMC yi-semi-synthetic polymer ephuma kwi-cellulose.Inenani leempawu ezenza ukuba zilungele ukusetyenziswa kumayeza ezilwanyana.Ezi propati ziquka:

Ukunyibilika kwamanzi: HPMC kakhulu ukunyibilika emanzini, nto leyo ethetha ukuba lula ukunyibilika emanzini kunye nezinye izisombululo aqueous.Oku kwenza kube lula ukudibanisa kumayeza ezilwanyana.

Ukuziphatha kwePseudo-plastiki: I-HPMC ibonisa ukuziphatha kwe-pseudo-plastiki, oku kuthetha ukuba i-thixotropic kunye ne-shear-thinning.Le propati ivumela ukuba inciphise i-viscosity yokumiswa xa iphantsi koxinzelelo lwe-shear, okwenza kube lula ukulawula iyeza lezilwanyana.

Isakhono sokwenza ifilim: I-HPMC inamandla okwenza ifilim, nto leyo ethetha ukuba inokwenza umaleko okhuselayo kumphezulu wamasuntswana amayeza onyango lwezilwanyana, nto leyo enceda ukuwakhusela ekuthotyweni nasekuhlanganiseni.

Iimpawu ze-Mucoadhesive: I-HPMC ineempawu ze-mucoadhesive, nto leyo ethetha ukuba inokubambelela kwiindawo ze-mucosal emzimbeni.Le propati iluncedo kakhulu kwiinkqubo zokunikezelwa kweziyobisi ngomlomo nangeempumlo, njengoko ivumela ixesha elide loqhagamshelwano kunye nomphezulu we-mucosal kunye nokuphuculwa kokufunxa ichiza.

Ukusetyenziswa kwe-HPMC kwiVeterinary Medicine

I-HPMC isetyenziswa kwiindidi zamayeza ezilwanyana.Ezinye zezona zinto ziqhelekileyo zokusetyenziswa kwe-HPMC kunyango lwezilwanyana ziquka:

Uzinziso: I-HPMC isetyenziselwa ukuphucula uzinzo lwamayeza ezilwanyana.Inokunceda ukuthintela ukudityaniswa kwamasuntswana, i-flocculation, kunye ne-sedimentation, enokuphucula ubomi beshelufu yeyeza.

Ukuguqulwa kweRheological: I-HPMC ingasetyenziselwa ukuguqula iimpawu ze-rheological zamayeza ezilwanyana.Inokunceda ukunciphisa i-viscosity yeyeza, enokwenza kube lula ukulawula.

Ukukhululwa okulawulwayo: I-HPMC ingasetyenziselwa ukuphumeza ukukhululwa okulawulwayo kwamachiza kumayeza ezilwanyana.Isakhono sokwenza ifilimu ye-HPMC siyivumela ukuba yenze umaleko okhuselayo kumphezulu wamasuntswana echiza, ezinokucothisa ukukhutshwa kwechiza emzimbeni.

Ukomelezwa kweBioavailability: I-HPMC inokuphucula ukubakho kwamachiza kumayeza ezilwanyana.Iimpawu ze-mucoadhesive ze-HPMC zivumela ukuba zihambelane ne-mucosal surfaces emzimbeni, ezinokuthi ziphucule ukufunxwa kweziyobisi kunye ne-bioavailability.

Ukufihla incasa: I-HPMC ingasetyenziselwa ukugquma incasa engathandekiyo yamachiza kumayeza ezilwanyana.Oku kuluncedo kakhulu kwimixube yokwenziwa ngomlomo, njengoko kunokwenza iyeza libe nencasa ngakumbi kwaye kube lula ukulisebenzisa kwizilwanyana.

Imixube emixholweni: I-HPMC ikwasetyenziswa kwimixube esematheni kunyango lwezilwanyana.Ingasetyenziswa njenge-thickener, stabilizer, kunye ne-emulsifier kwi-creams, i-ointments, kunye nejeli.Ukuziphatha kwe-pseudo-plastiki ye-HPMC ivumela ukuba iphucule ukusasazeka kunye nokuhambelana kwe-topical formulation.

Amayeza atofwayo: I-HPMC isenokusetyenziswa kwimixube etofwayo kwiyeza lezilwanyana.Ingasetyenziselwa njenge-arhente yokumisa kunye ne-viscosity enhancer ukuphucula uzinzo kunye neempawu ze-rheological zenaliti.

Ukuqukumbela

Ukuqukumbela, i-HPMC yipolymer eguquguqukayo esetyenziswa kakhulu kwishishini lamayeza, kubandakanywa neyeza lezilwanyana.Ukunyibilika kwayo kwamanzi, ukuziphatha kwe-pseudo-plastiki, amandla okwenza ifilimu, iipropathi ze-mucoadhesive, kunye nobuchule bokufihla incasa buyenza ibe sisithako esibalulekileyo ekuqulunqweni kwamayeza ezilwanyana.HPMC unako ukuphucula uzinzo, iimpawu rheological, bioavailability, kunye nencasa amayeza ezilwanyana, ukwenza kube lula ukulawula kunye nokusebenza ngakumbi ekunyangeni izilwanyana.