HPMC bakeng sa meriana ea bongaka ba liphoofolo

Hydroxypropyl methylcellulose (HPMC) ke polima e sebelisoang haholo indastering ea meriana, hape e sebelisoa ho lokiseng meriana ea bongaka ba liphoofolo.HPMC ke ether e qhibilihang ka metsing, e seng ea ionic cellulose e nkiloeng ho selulose ea tlhaho.Ke polymer e bolokehileng, e lumellanang le biodegradable e sebelisoang ho ntlafatsa botsitso, thepa ea rheological, le bioavailability ea meriana ea bongaka ba liphoofolo.Sehloohong sena, re tla tšohla thepa le ts'ebeliso ea HPMC ho bongaka ba liphoofolo.

Thepa ea HPMC

HPMC ke semi-synthetic polymer e nkiloeng ho selulose.E na le lintho tse ngata tse etsang hore e loketse ho sebelisoa meriana ea bongaka ba liphoofolo.Lintho tsena li kenyelletsa:

Ho qhibiliha ha metsi: HPMC e qhibiliha haholo ka metsing, ho bolelang hore e ka qhibiliha habonolo metsing le litharollo tse ling tse nang le metsi.Sena se etsa hore ho be bonolo ho kenyelletsa meriana ea bongaka ba liphoofolo.

Boitšoaro ba pseudo-polasetiki: HPMC e bonts'a boits'oaro ba pseudo-plastiki, ho bolelang hore ke thixotropic ebile ke ho kuta.Thepa ena e e lumella ho fokotsa viscosity ea ho emisoa ha e le tlas'a khatello ea ho kuta, e leng ho nolofalletsang ho fana ka meriana ea bongaka ba liphoofolo.

Bokhoni ba ho etsa lifilimi: HPMC e na le bokhoni bo botle ba ho etsa filimi, ho bolelang hore e ka etsa lera le sireletsang holim'a likaroloana tsa meriana ea bongaka ba liphoofolo, e thusang ho li sireletsa ho senyeha le ho bokellana.

Mucoadhesive properties: HPMC e na le thepa ea mucoadhesive, e bolelang hore e ka khomarela bokaholimo ba mucosal 'meleng.Thepa ena e bohlokoa haholo bakeng sa lits'ebetso tsa phepelo ea lithethefatsi tsa molomo le linko, kaha e lumella nako e telele ea ho ikopanya le bokaholimo ba mucosal le ho monya lithethefatsi ho ntlafalitsoeng.

Tšebeliso ea HPMC ho Meriana ea Liphoofolo

HPMC e sebelisoa mefuteng e fapaneng ea meriana ea bongaka ba liphoofolo.Tse ling tsa litšebeliso tse atileng haholo tsa HPMC ho bongaka ba liphoofolo li kenyelletsa:

Ho tsitsisa: HPMC e sebelisetsoa ho ntlafatsa botsitso ba meriana ea bongaka ba liphoofolo.E ka thusa ho thibela ho kopana ha likaroloana, flocculation, le sedimentation, e leng ho ka ntlafatsang bophelo ba sethala sa meriana.

Phetoho ea Rheological: HPMC e ka sebelisoa ho fetola thepa ea rheological ea meriana ea bongaka ba liphoofolo.E ka thusa ho fokotsa viscosity ea meriana, e ka etsang hore ho be bonolo ho fana ka eona.

Tokollo e laoloang: HPMC e ka sebelisoa ho fihlela tokollo e laoloang ea lithethefatsi ho tsoa merianang ea bongaka ba liphoofolo.Bokhoni ba ho etsa filimi ea HPMC bo e lumella ho etsa lera le sireletsang holim'a likaroloana tsa lithethefatsi, tse ka liehisang ho lokolloa ha moriana 'meleng.

Matlafatso ea bioavailability: HPMC e ka ntlafatsa bioavailability ea meriana meriana ea bongaka ba liphoofolo.Thepa ea mucoadhesive ea HPMC e e lumella ho khomarela bokaholimo ba mucosal 'meleng, e ka ntlafatsang ho monya ha lithethefatsi le bioavailability.

Latsoa masking: HPMC e ka sebelisoa ho pata tatso e sa thabiseng ea lithethefatsi meriana ea bongaka ba liphoofolo.Sena se bohlokoa haholo bakeng sa litlhare tse nooang, kaha se ka etsa hore moriana o be monate haholoanyane 'me ho be bonolo ho o fa liphoofolo.

Meetso ea lihlooho: HPMC e boetse e sebelisoa mefuteng ea lihlooho bakeng sa meriana ea bongaka ba liphoofolo.E ka sebelisoa e le motenya, stabilizer le emulsifier ka litlolo, mafura le ligel.Boitšoaro ba pseudo-plastiki ba HPMC bo e lumella ho ntlafatsa ho ata le ho tsitsa ha sebopeho sa lihlooho.

Metsoako e nang le ente: HPMC e ka boela ea sebelisoa mefuteng e nang le ente bakeng sa meriana ea bongaka ba liphoofolo.E ka sebelisoa e le moemeli oa ho emisa le ho ntlafatsa viscosity ho ntlafatsa botsitso le thepa ea rheological ea ente.

Qetello

Qetellong, HPMC ke polymer e feto-fetohang e sebelisoang haholo indastering ea meriana, ho kenyeletsoa le bongaka ba liphoofolo.Ho qhibiliha ha eona ka metsing, boits'oaro ba pseudo-plastiki, bokhoni ba ho etsa filimi, thepa ea ho khomarela li-mucoadhesive, le bokhoni ba ho pata tatso li etsa hore e be motsoako oa bohlokoa ho etsoa ha meriana ea bongaka ba liphoofolo.HPMC e ka ntlafatsa botsitso, thepa ea rheological, bioavailability, le palatability ea meriana ea bongaka ba liphoofolo, e etsa hore e be bonolo ho fana ka eona le ho sebetsa hantle ho phekola liphoofolo.