IHydroxypropyl methylcellulose (HPMC) yipolymer eguquguqukayo esetyenziswa ngokuqhelekileyo kumayeza, izinto zokuthambisa, izinto zokwakha, kunye neemveliso zokutya.i-pH, okanye umlinganiselo we-acidity okanye i-alkalinity yesisombululo, inokuchaphazela kakhulu iipropati kunye nokusebenza kwe-HPMC.
Ukunyibilika:
I-HPMC ibonisa ukunyibilika okuxhomekeke kwi-pH.Kwi-pH ephantsi (iimeko ze-acidic), i-HPMC ithande ukunganyibiliki ngenxa ye-protonation yamaqela ayo e-hydroxyl, ekhokelela ekwandeni kwe-intermolecular hydrogen bonding kunye nokuncipha kwe-solubility.Njengoko i-pH inyuka (isiba yi-alkaline ngakumbi), i-HPMC iba yi-soluble ngakumbi ngenxa yokuchithwa kwamaqela ayo asebenzayo.
I-solubility ye-HPMC inokunyuswa kwimixube yamachiza ukulawula ukukhutshwa kwechiza.Iihydrogels ezisekwe kwi-pHMC-sensitive HPMC, umzekelo, zinokuyilwa ukukhupha amachiza ngendlela exhomekeke kwi-pH, apho ipholima idumba kwaye ilikhuphe iyeza ngokulula ngakumbi kumanqanaba athile e-pH.
Viscosity:
I-viscosity yezisombululo ze-HPMC iphenjelelwa yi-pH.Kwi-pH ephantsi, iimolekyuli ze-HPMC zikholisa ukuhlangana ngenxa yokwanda kwe-hydrogen bonding, ekhokelela kwi-viscosity ephezulu.Njengoko i-pH inyuka, ukunyanzeliswa phakathi kwamatyathanga e-HPMC ahlawuliswa kakubi ngenxa yokuchithwa kweprotonation kunciphisa ukuhlanganisana, okukhokelela kwi-viscosity ephantsi.
Kwizicelo ezinje ngamayeza kunye nezithambiso, ukulawula i-viscosity yezisombululo ze-HPMC kubalulekile ekuphumezeni iimpawu zemveliso ezinqwenelekayo.Uhlengahlengiso lwe-pH lunokusetyenziswa ukulungelelanisa i-viscosity ukuhlangabezana neemfuno ezithile zokwenziwa.
Ukwenziwa kwefilimu:
I-HPMC isoloko isetyenziswa ekulungiseleleni iifilim kwiinkqubo zokuhanjiswa kweziyobisi, iingubo, kunye nezinto zokupakisha.I-pH yesisombululo sokwenza ifilimu ichaphazela iipropati zeefilimu ezibangelwayo.
Kwi-pH ephantsi, iifilimu ze-HPMC zithande ukuba compact kwaye zixinene ngenxa yokwanda kwemolekyuli.Ngokwahlukileyo, kwi-pH ephezulu, iifilimu ze-HPMC zibonisa i-porosity ephezulu kunye nokuguquguquka ngenxa yokunciphisa ukuhlanganiswa kunye nokunyuka kokunyibilika.
Emulsification kunye noZinziso:
Kwizinto zokuthambisa kunye nokutya, i-HPMC isetyenziswa njenge-emulsifier kunye ne-stabilizer.I-pH yenkqubo inefuthe kwi-emulsification kunye neempawu zokuzinzisa ze-HPMC.
Kumanqanaba ahlukeneyo e-pH, iimolekyuli ze-HPMC zifumana utshintsho oluhambelanayo, oluchaphazela ukukwazi kwabo ukwenza ii-emulsions ezizinzileyo.Ukulungiswa kwe-pH kubalulekile ukufezekisa ukuzinza kwe-emulsion efunwayo kunye nokuthungwa kwiimveliso zokuthambisa kunye nokutya.
IGelation:
I-HPMC inokwenza iijeli ezibuyiselwa umva nge-thermal kumaqondo obushushu aphezulu.I-pH yesisombululo ichaphazela ukuziphatha kwe-gelation ye-HPMC.
Kwiimveliso zokutya ezifana needessert kunye neesosi, ukulungiswa kwe-pH kunokuqashwa ukulawula iimpawu ze-gelation ze-HPMC kunye nokufezekisa ukuthungwa okufunwayo kunye ne-mouthfeel.
Ukuhambelana nezinye izithako:
I-pH yokwakheka inokuchaphazela ukuhambelana kwe-HPMC kunye nezinye izithako.Umzekelo, kwimixube yamayeza, i-pH inokuchaphazela uzinzo lwentsebenziswano yeziyobisi-HPMC.
Ukulungiswa kwe-pH kubalulekile ukuqinisekisa ukuhambelana phakathi kwe-HPMC kunye namanye amacandelo ekuqulunqweni, ngaloo ndlela kugcinwe ukuthembeka kwemveliso kunye nokusebenza.
I-pH ichaphazela kakhulu i-solubility, i-viscosity, ukubunjwa kwefilimu, i-emulsification, i-gelation, kunye nokuhambelana kwe-HPMC kwizicelo ezahlukeneyo.Ukuqonda indlela yokuziphatha exhomekeke kwi-pH ye-HPMC kubalulekile ekuphuculeni imixube kunye nokufezekisa iimpawu ezinqwenelekayo zemveliso.
Ixesha lokuposa: Apr-18-2024