Hydroxypropyl Methylcellulose (HPMC) ke polymer e sebelisoang haholo e nang le lits'ebetso tse fapaneng liindastering tse fapaneng, ho kenyeletsoa meriana, lijo, kaho le litlolo.Motsoako ona o feto-fetohang o na le thepa e ikhethang e etsang hore e be ea bohlokoa mekhoeng le lits'ebetsong tse fapaneng.
1. Sebopeho le Thepa
1.1 Sebopeho sa Limolek'hule: HPMC ke polymer ea semisynthetic e nkiloeng ho selulose, e leng biopolymer e ngata ka ho fetisisa Lefatšeng.E hlahisoa ka phetoho ea lik'hemik'hale ea selulose, haholo-holo ka ho e phekola ka propylene oxide le methyl chloride ho hlahisa lihlopha tsa hydroxypropyl le methyl, ka ho latellana.
1.2 Thepa ea 'Mele: HPMC hangata e fumanoa e le phofo e tšoeu kapa e sa bosoeu.Ha e na monko, ha e latsoehe, ebile ha e chefo, e etsa hore e bolokehe bakeng sa ho sebelisoa lits'ebetsong tse fapaneng.The solubility ea HPMC itšetlehile ka lintlha tse kang boima ba molek'hule, tekanyo ea ho fetola, le mocheso.E bonts'a thepa e ntle ea ho etsa lifilimi mme e ka etsa lifilimi tse pepeneneng ha e qhibiliha ka metsing.
1.3 Thepa ea Rheological: Litharollo tsa HPMC li bonts'a boits'oaro ba pseudoplastic, ho bolelang hore viscosity ea bona e fokotseha ka sekhahla sa ho kuta.Thepa ena e na le molemo lits'ebetsong tse joalo ka li-coatings, moo ho lakatsehang kopo e bonolo le ho lekana.
2. Tšimoloho
Tšimoloho ea HPMC e kenyelletsa mehato e mengata.Ntlha ea pele, cellulose e atisa ho fumanoa ho tloha makhasi a lehong kapa lithareng tsa k'hothone.Ebe, e etsa liphetoho tsa etherification ka propylene oxide le methyl chloride tlas'a maemo a laoloang ho hlahisa lihlopha tsa hydroxypropyl le methyl mokokotlong oa cellulose.The degree of substitution (DS) ea lihlopha tsena e ka fetoloa ho lokisa thepa ea HPMC polymer e hlahisoang bakeng sa lits'ebetso tse ikhethileng.
3. Likopo
3.1 Meriana ea Meriana: HPMC e sebelisoa haholo mekhoeng ea meriana ka lebaka la ho lumellana ha eona le biocompatibility, thepa ea mucoadhesive, le matla a ho lokolloa a laoloang.Hangata e sebelisoa e le setlamo, sa pele sa filimi, se sa thekeseleng, le se lokollang ka nako e telele mekhoeng ea matlapa.Ho feta moo, li-gel formulations tse thehiloeng ho HPMC li sebelisoa litokisetsong tsa mahlo ho lelefatsa nako ea ho lula ha lithethefatsi sebakeng sa mahlo.
3.2 Indasteri ea Lijo: indastering ea lijo, HPMC e sebelisoa e le setei, se tsitsitseng, emulsifier, le moemeli oa ho boloka mongobo.Hangata e fumanoa lihlahisoa tsa lebese, lintho tse halikiloeng, li-sauces le lino tse tahang.HPMC e thusa ho ntlafatsa sebopeho, botsitso, le molomo oa lihlahisoa tsa lijo ntle le ho fetola tatso ea tsona kapa boleng ba phepo.
3.3 Lisebelisuoa tsa Kaho: HPMC ke motsoako oa bohlokoa oa thepa ea kaho e kang seretse se thehiloeng ho samente, li-renders le li-adhesives tsa lithaele.E sebetsa e le sesebelisoa sa ho boloka metsi, e ntlafatsa ts'ebetso, e fokotsa ho fokotseha, 'me e ntlafatsa ho khomarela lisebelisoa tsena ho li-substrates.Seretse se thehiloeng ho HPMC se bonts'a khanyetso e ntlafalitsoeng ea ho peperana le ho honyela, e lebisang ho meaho e tšoarellang le e khahlisang ka bokhabane.
3.4 Litlolo: indastering ea litlolo, HPMC e sebelisoa mefuteng e fapaneng ea litlolo, ho kenyeletsoa litlolo, litlolo, ligel le mascara.E sebetsa e le motenya, emulsifier, stabilizer, le filimi ea pele lihlahisoa tsena.HPMC e fana ka thepa e lakatsehang ea rheological, e ntlafatsa sebopeho, 'me e fana ka litlamorao tsa nako e telele ho litlolo tsa litlolo.
4. Ditebello Tsa Bokamoso
Tlhokahalo ea HPMC e lebelletsoe ho tsoela pele ho hola lilemong tse tlang, e tsamaisoa ke ho holisa lits'ebetso tsa meriana, lijo, kaho le litlolo.Boiteko bo tsoelang pele ba lipatlisiso bo tsepamisitse maikutlo ho ntlafatseng liqapi tse ncha le ho ntlafatsa ts'ebetso ea lihlahisoa tse seng li ntse li le teng.Tsoelopele ho nanotechnology e ka lebisa nts'etsopele ea li-nanocomposites tse thehiloeng ho HPMC tse nang le thepa e ntlafalitsoeng ea mochini, e futhumatsang le e thibelang, ho bula menyetla e mecha liindastering tse fapaneng.
Hydroxypropyl Methylcellulose (HPMC) ke polymer e sebetsang ka mefuta e mengata e nang le mefuta e mengata ea ts'ebeliso ho liindasteri tse fapaneng.Motsoako oa eona o ikhethang oa thepa, ho kenyeletsoa biocompatibility, taolo ea rheological, le bokhoni ba ho etsa lifilimi, e etsa hore e be ea bohlokoa haholo ho tsa meriana, lijo, kaho le litlolo.Ka lipatlisiso le nts'etsopele e ntseng e tsoela pele, HPMC e ikemiselitse ho lula e le motsoako oa mantlha mekhoeng le lisebelisoa tse fapaneng nakong e tlang e lebelletsoeng.
Nako ea poso: Apr-15-2024