Hypromellose - Sesebelisoa sa setso sa meriana

Hypromellose, eo hape e tsejoang e le hydroxypropyl methylcellulose (HPMC), ke motsoako oa setso oa meriana o sebelisoang haholo indastering ea meriana bakeng sa merero e fapaneng.Ke ea sehlopha sa cellulose ethers 'me e tsoa ho cellulose, polymer ea tlhaho e fumanoang marakong a lisele tsa semela.Hypromellose e entsoe ka ho phekola cellulose ka propylene oxide le methyl chloride.

Mona ke likarolo tse ling tsa bohlokoa le mesebetsi ea hypromellose joalo ka mothusi oa meriana:

1. Binder: Hypromellose hangata e sebelisoa e le tlamahano mefuteng ea matlapa.E thusa ho kopanya metsoako e sebetsang ea meriana (APIs) le lisebelisoa tse ling hammoho, ho netefatsa hore letlapa le boloka sebōpeho le botšepehi nakong ea ho etsa le ho sebetsana le eona.
2. Film Coating Agent: Hypromellose e sebelisoa e le moemeli oa ho roala filimi ho fana ka tšireletso le boreleli ho lipilisi le li-capsules.Ho roala hona ho ka pata litakatso tse sa thabiseng, ho ntlafatsa ponahalo, ho sireletsa khahlanong le mongobo, le ho laola ho lokolloa ha moriana.
3. Matrix Former: Lihlopheng tsa tokollo e tsitsitseng, hypromellose e ka sebelisoa joalo ka matrix ea pele.E etsa matrix e kang gel ha e kopana le metsi, e laola ho lokolloa ha lithethefatsi ka nako e telele, kahoo e fana ka ketso ea nako e telele ea lithethefatsi.
4. Viscosity Modifier: Hypromellose hangata e sebelisoa ho lokisa viscosity ea metsoako ea mokelikeli joalo ka ho emisoa ka molomo le litokisetso tsa lihlooho.E thusa ho tsitsisa ho emisoa, ho laola rheology, le ho ntlafatsa ho tšolloa le ho ata.
5. Disintegrant: Ka mekhoa e itseng, hypromellose e ka sebetsa e le ntho e senyang, e khothalletsang karohano e potlakileng ea matlapa kapa li-capsules hore e be likaroloana tse nyenyane ha li pepesehetse metsi ka har'a pampitšana ea mala, ka tsela eo ho nolofaletsa ho qhibiliha ha lithethefatsi le ho monya.
6. Emulsifier le Stabilizer: Hypromellose e ka sebetsa e le moemeli oa emulsifying le stabilizer ka li-emulsions le litlolo, ho thusa ho theha mekhoa e tsitsitseng le e ts'oanang bakeng sa kopo ea lihlooho.
7. Li-mucoadhesive: Ka li-ocular formulations kapa li-sprays tsa nasal, hypromellose e ka sebetsa e le ntho e khomarelang mucoadhesive, e khothalletsang ho khomarela li-mucosal holim'a metsi le ho lelefatsa nako ea ho kopana le lithethefatsi le lisele tse lebisitsoeng.

Ka kakaretso, hypromellose ke motsoako oa meriana o sebetsang ka mefuta-futa oa bohlokoa bakeng sa biocompatibility, non-toxicity, le mefuta e mengata ea lisebelisoa ka mefuta ea litekanyetso tse kang matlapa, li-capsules, lifilimi, li-suspensions le litlolo.Lintho tsa eona li etsa hore e be karolo ea bohlokoa ha ho etsoa lihlahisoa tsa meriana tse fapa-fapaneng, ho tlatsetsa katlehong ea tsona, botsitso le kamohelo ea mokuli.