Chii chinonzi hypromellose phthalate?

Hypromellose phthalate (HPMCP) imhando yemishonga yemishonga inoshandiswa mukugadzira mafomu emushonga wemuromo, kunyanya mukugadzirwa kwemapiritsi akavharidzirwa ne enteric uye capsules.Iyo inotorwa kubva ku cellulose, inova yakasikwa polymer inoumba chikamu chechimiro chechirimwa masero madziro.HPMCP inonyungudika mumvura, anionic polymer iyo inowanzoshandiswa senge enteric coating material nekuda kwekunaka kwayo firimu-kugadzira zvinhu, kugadzikana, uye kuramba kune gastric fluid.

HPMCP yakatanga kuunzwa mukutanga kwema1970 uye yave kushandiswa zvakanyanya enteric coating material nekuda kwezvimiro zvayo zvakasiyana.Iyo inogadzirwa ne esterification ye hypromellose ine phthalic acid uye inowanikwa mumhando dzakasiyana dzemagiredhi, zvichienderana nehuwandu hwephthalation uye huremu hwemamorekuru epolymer.Magiredhi anonyanya kushandiswa eHPMCP iHPMCP-55, HPMCP-50, uye HPMCP-HP-55, ane madhigirii akasiyana ephthalation uye akakodzera kushandiswa mumhando dzakasiyana dzemaumbirwo.

Basa guru reHPMCP mukugadzirwa kwemishonga ndeyekuchengetedza zvinhu zvinoshanda zvemushonga kubva pakuora munzvimbo ine acidic yemudumbu.Kana piritsi kana capsule ine HPMCP ikanyudzwa, iyo yekuputira inoramba yakasimba mudumbu nekuda kweiyo yakaderera pH, asi kana iyo dosage fomu yasvika kune yakawanda alkaline nharaunda yemudumbu mudiki, iyo yekuputira inotanga kunyungudika uye kusunungura zvinoshandiswa zvinoshandiswa.Uku kunonoka kuburitswa kunobatsira kuve nechokwadi chekuti mushonga unounzwa kunzvimbo yekuita uye kuti kushanda kwawo hakukanganisirwe negastric acid.