Nibihe bintu bya chimique ya Ethyl selulose?

Ethylcellulose ni inkomoko ya selile, polymer karemano igizwe na glucose.Ihinduranya mugukora selile hamwe na Ethyl chloride cyangwa okiside ya Ethylene, ikabyara molekile ya selile yasimbuwe igice.Ethylcellulose ifite imiterere yimiti ituma igira akamaro mubikorwa bitandukanye byinganda na farumasi.

Imiterere ya molekulari:

Ethylcellulose igumana imiterere shingiro ya selile, igizwe no gusubiramo ibice bya glucose bihujwe hamwe na β-1,4-glycosidic.

Gusimbuza Ethyl bibaho cyane cyane kumatsinda ya hydroxyl yumugongo wa selile, bivamo impamyabumenyi zitandukanye zo gusimburana (DS) byerekana impuzandengo y amatsinda ya Ethyl kuri buri gice cya glucose.

Urwego rwo gusimbuza rugira ingaruka kumiterere ya Ethylcellulose, harimo gukomera, kwiyegeranya, hamwe nubushobozi bwo gukora film.

Gukemura:

Bitewe na hydrophobique ya groupe ya Ethyl, Ethylcellulose ntishobora gushonga mumazi.

Irerekana ibishishwa mumashanyarazi atandukanye, harimo alcool, ketone, esters, na hydrocarbone ya chlorine.

Ubushobozi bwiyongera hamwe no kugabanya uburemere bwa molekile no kongera urugero rwa ethoxylation.

Imiterere ya firime:

Ethylcellulose izwiho ubushobozi bwo gukora firime, ikagira agaciro mugukora amakoti, firime, hamwe na farumasi yimiti igenzurwa.

Ubushobozi bwa Ethylcellulose gushonga mumashanyarazi atandukanye yumubiri buteza imbere gukora firime, hamwe no guhumeka kwumuti usize firime imwe.

Ibikorwa:

Ethylcellulose yerekana ubushake buke mubihe bisanzwe.Ariko, irashobora guhindurwa muburyo bwa chimique binyuze mubitekerezo nka etherification, esterification, hamwe no guhuza.

Etherification reaction ikubiyemo kwinjiza izindi nsimburangingo kumugongo wa selile, bityo guhindura imitungo.

Esterification irashobora kubaho mugukora Ethylcellulose hamwe na acide karubasi ya acide cyangwa chloride ya aside, ikabyara ester ya selulose ihindagurika kandi nibindi bintu.

Imyiyerekano ihuza ibikorwa irashobora gutangizwa kugirango imbaraga zumukanishi hamwe nubushyuhe bwumuriro wa Ethyl selulose membrane.

Imikorere yubushyuhe:

Ethylcellulose yerekana ubushyuhe bwumuriro murwego runaka rwubushyuhe, burenze kubora.

Kwangirika k'ubushyuhe mubisanzwe bitangira hafi 200-250 ° C, bitewe nibintu nkurwego rwo gusimbuza no kuba hari plasitike cyangwa inyongeramusaruro.

Isesengura rya Thermogravimetric (TGA) hamwe na calorimetrie itandukanye yo gusikana (DSC) bikunze gukoreshwa muburyo bwo kuranga imyitwarire yubushyuhe bwa Ethylcellulose hamwe nuruvange rwayo.

guhuza:

Ethylcellulose ihujwe nizindi polymers zitandukanye, plasitike ninyongeramusaruro, bigatuma bikwiranye nibindi bikoresho kugirango ugere kubintu byifuzwa.

Inyongeramusaruro zisanzwe zirimo plasitike nka polyethylene glycol (PEG) na triethyl citrate, byongera imiterere nogukora firime.

Guhuza nibikoresho bikora bya farumasi (APIs) nibyingenzi mugutegura imiti yimiti ya farumasi nka tableti yagutse-irekura hamwe na transdermal.

Imikorere ya bariyeri:

Filime ya Ethylcellulose yerekana inzitizi nziza zirwanya ubushuhe, imyuka n imyuka kama.

Iyi barrière ituma Ethylcellulose ikwiranye no gupakira porogaramu aho kurinda ibintu bidukikije ari ngombwa kugirango ubungabunge ubusugire nubuzima bwiza.

Imiterere ya Rheologiya:

Ubwiza bwibisubizo bya Ethylcellulose biterwa nibintu nko kwibanda kuri polymer, urugero rwo gusimbuza, nubwoko bwa solvent.

Igisubizo cya Ethylcellulose gikunze kwerekana imyitwarire ya pseudoplastique, bivuze ko ububobere bwabo bugabanuka hamwe no kongera umuvuduko wogosha.

Ubushakashatsi bwa Rheologiya nibyingenzi kugirango dusobanukirwe n'ibiranga ibisubizo bya Ethylcellulose mugihe cyo gutunganya no gutwikira.

Ethylcellulose ni polymer itandukanye ifite ibintu byinshi bya chimique bigira uruhare mubikorwa byayo mubikorwa bitandukanye byinganda na farumasi.Ubushobozi bwayo, ubushobozi bwo gukora firime, reaction, stabilite yumuriro, guhuza, imiterere ya barrière na rheologiya bituma iba ibikoresho byagaciro byo gutwikira, firime, kugenzura ibyasohotse hamwe nibisubizo byo gupakira.Ubundi bushakashatsi niterambere murwego rwibikomoka kuri selile bikomeje kwagura porogaramu nubushobozi bwa Ethylcellulose mubice bitandukanye.