Iyini i-HPMC E3?

I-HPMC E3, noma i-hydroxypropyl methylcellulose E3, iwuhlobo lwe-cellulose ether evame ukusetshenziswa embonini yezemithi njenge-binder, thickener, kanye ne-ejenti yokukhululwa eqhubekayo ekwakhiweni kwethebhulethi nama-capsule.Kuyi-polymer engeyona i-ionic etholakala ku-cellulose yemvelo ngokuguqulwa kwamakhemikhali, i-HPMC E3 viscosity range ingu-2.4-3.6 mPas.

Embonini yezemithi, i-HPMC E3 ivame ukusetshenziswa njengenye indlela kwezinye izibophezelo, njengesitashi noma i-gelatin, ngoba iyisitshalo esisekelwe esitshalweni, enye indlela yemifino.Ibuye ihambisane kakhulu nezinhlobonhlobo zezithako zemithi esebenzayo (ama-API) kanye nezinto ezisizayo, okuyenza ibe isithako esiguquguqukayo nesisetshenziswa kakhulu ekwakhiweni kwemithi eminingi.

Enye yezinzuzo ezibalulekile ze-HPMC E3 ezinhlelweni zemithi ikhono layo lokusebenza njengesibophezelo.Uma isetshenziswa njengesibophezelo, i-HPMC E3 isiza ukubamba isithako esisebenzayo nezinye izinto ezisizayo ndawonye, ​​yakhe ithebhulethi noma i-capsule.Lokhu kubalulekile ngoba kuqinisekisa ukuthi ithebhulethi noma i-capsule igcina isimo sayo nobuqotho kuyo yonke inqubo yokukhiqiza nangesikhathi sokugcina nokuhamba.

I-HPMC E3 futhi inezici ezinhle kakhulu zokujiya, eziyenza isebenziseke njenge-ejenti yokumisa uketshezi ekwakhiweni koketshezi.Kuyasiza ukuvimbela ukulungiswa kwesithako esisebenzayo nezinye izinhlayiya oketshezini, ukuqinisekisa ukuthi ukumiswa kuhlala ku-homogeneous futhi umfaniswano kuyo yonke impilo yeshalofu yomkhiqizo.

Okunye ukusetshenziswa okubalulekile kwe-HPMC E3 kwezemithi ukusetshenziswa kwayo njenge-ejenti yokukhululwa eqhubekayo.Uma isetshenziswa kulesi sikhundla, i-HPMC E3 isiza ukunciphisa ukukhishwa kwesithako esisebenzayo kusuka kuthebhulethi noma i-capsule, okuvumela ukukhululwa okulawulwayo futhi kancane kancane ngokuhamba kwesikhathi.Lokhu kubaluleke kakhulu emithini edinga ukukhishwa kancane kancane futhi kancane kancane isikhathi eside ukuze igcine umphumela wayo wokwelapha.

I-HPMC E3 iphinde isetshenziswe njenge-ejenti enamathelayo yamaphilisi namaphilisi.Uma isetshenziswa kulo mthamo, isiza ukuvikela isithako esisebenzayo ekonakalisweni ukukhanya, umswakama, nezinye izici zemvelo, iqinisekisa ukuthi umuthi uhlala usebenza futhi uzinzile kukho konke ukuphila kwawo kweshalofu.Izembatho ze-HPMC E3 nazo zingasetshenziswa ukuvala ukunambitheka nephunga lesithako esisebenzayo, kukwenze kunambitheke kakhulu ezigulini.

Ngaphezu kokusetshenziswa kwayo kumaphilisi namaphilisi, i-HPMC E3 iphinde isetshenziswe kwezinye izinhlobo zemithi, ezifana nokhilimu, amajeli, namafutha okugcoba.Kulezi zakhiwo, kusiza ukuthuthukisa i-viscosity kanye nokuthungwa komkhiqizo, okwenza kube lula ukufaka esikhumbeni noma kwenye indawo ethintekile.I-HPMC E3 iphinde isetshenziswe njenge-ejenti ye-gelling ekwakhiweni kwezihloko, isiza ukwakha ukufana okufana nejeli okunikeza ukukhululwa okuqhubekayo kwesithako esisebenzayo.

Umthamo onconyiwe we-HPMC E3 ekwenziweni kwemithi uyahlukahluka kuye ngohlelo oluthile kanye nezici ezifiswayo zomkhiqizo wokugcina.Ngokuvamile, umthamo we-1% kuya ku-5% we-HPMC E3 ngokusekelwe esilinganisweni sesisindo sokwakheka kuyanconywa.