I-Hydroxypropyl methylcellulose iyi-polymer encibilikayo emanzini edumile eyenza isisombululo esicacile nesizinzile emanzini futhi isetshenziswa kabanzi ezimbonini zemithi, zokudla nezokwakha.Kuyi-ionic cellulose-based raw material ethuthukisa ukuhlanganisa nokuhlangana komkhiqizo wokugcina.Ukuze kuqinisekiswe ukusebenza kwekhwalithi ephezulu ye-hydroxypropyl methylcellulose, umkhiqizo udinga ukuhlolwa futhi uqeqeshwe ngaphambi kokusetshenziswa.Kulesi sihloko, sizoxoxa ngezindlela ezintathu ezithembekile zokutshela ikhwalithi ye-hydroxypropyl methylcellulose.
1. Ukuhlolwa kwe-viscosity
I-viscosity ye-hydroxypropyl methylcellulose iyipharamitha ebalulekile yokunquma ikhwalithi yayo.I-viscosity ukumelana koketshezi nokugeleza futhi kukalwa nge-centipoise (cps) noma i-mPa.s.I-viscosity ye-hydroxypropyl methylcellulose iyahlukahluka kuye ngesisindo samangqamuzana ayo kanye nezinga lokushintshwa.Lapho izinga lokushintsha liphakeme, i-viscosity yomkhiqizo iyancipha.
Ukuze uhlole i-viscosity ye-hydroxypropyl methylcellulose, chitha inani elincane lomkhiqizo emanzini futhi usebenzise i-viscometer ukukala i-viscosity yesisombululo.I-viscosity yesixazululo kufanele ibe phakathi kwebanga elinconyiwe elinikezwe umphakeli womkhiqizo.Umkhiqizo omuhle we-hydroxypropyl methylcellulose kufanele ube ne-viscosity engaguquki, okuyinkomba yokuhlanzeka kanye nosayizi wezinhlayiyana ezifanayo.
2. Ukuhlolwa esikhundleni
Izinga lokushintsha lisho isilinganiso senani lamaqembu e-hydroxyl ku-cellulose esikhundleni samaqembu e-hydroxypropyl noma e-methyl.Izinga lokushintsha liyinkomba yokuhlanzeka komkhiqizo, lapho izinga lokushintsha liphakeme, umkhiqizo umsulwa.Imikhiqizo yekhwalithi ephezulu ye-hydroxypropyl methylcellulose kufanele ibe nezinga eliphezulu lokushintshwa.
Ukuhlola izinga lokushintshwa, i-titration yenziwa nge-sodium hydroxide ne-hydrochloric acid.Nquma inani le-sodium hydroxide edingekayo ukuze unciphise i-hydroxypropyl methylcellulose futhi ubale izinga lokushintsha usebenzisa le fomula elandelayo:
I-Degree of Substitution = ([Ivolumu ye-NaOH] x [I-Molarity ye-NaOH] x 162) / ([Isisindo se-Hydroxypropyl Methyl Cellulose] x 3)
Izinga lokushintsha kufanele libe phakathi kwebanga elinconyiwe elinikezwe umphakeli womkhiqizo.Izinga lokushintshwa kwemikhiqizo yekhwalithi ephezulu ye-hydroxypropyl methylcellulose kufanele libe phakathi kwebanga elinconyiwe.
3. Ukuhlolwa kokuncibilika
Ukunyibilika kwe-hydroxypropyl methylcellulose kungenye ipharamitha eyinhloko enquma ikhwalithi yayo.Umkhiqizo kufanele uncibilike kalula emanzini futhi ungenzi izigaxa noma amajeli.Imikhiqizo yekhwalithi ephezulu ye-hydroxypropyl methylcellulose kufanele ichitheke ngokushesha nangokulinganayo.
Ukwenza ukuhlolwa kwe-solubility, chaza inani elincane lomkhiqizo emanzini bese ugoqa isisombululo kuze kuqedwe ngokuphelele.Isixazululo kufanele sicace futhi singabi nezigaxa noma ama-gel.Uma umkhiqizo ungancibiliki kalula noma wenze izigaxa noma amajeli, kungase kube uphawu lwekhwalithi embi.
Sengiphetha, i-hydroxypropyl methylcellulose iyimpahla eluhlaza esetshenziswa ezimbonini ezahlukahlukene.Ukuze kuqinisekiswe ikhwalithi ephezulu yomkhiqizo, ukuhlolwa kwe-viscosity, ukufaka esikhundleni kanye ne-solubility kuyenziwa.Lezi zivivinyo zizosiza ukuqonda ngokucacile izici zomkhiqizo futhi kusize ukuhlukanisa ikhwalithi yawo.Ikhwalithi ephezulu ye-hydroxypropyl methylcellulose ine-viscosity engaguquki, izinga eliphezulu lokushintshwa, futhi incibilika ngokushesha nangokufana emanzini.
Isikhathi sokuthumela: Jul-11-2023