A.Intshayelelo nge-HPMC:
1. Ukubunjwa kwemichiza kunye noLwakhiwo:
IHydroxypropyl Methylcellulose (HPMC) yi-semi-synthetic, ipholima enyibilikayo emanzini ephuma kwi-cellulose.
Ubume bayo bemolekyuli buqukethe i-cellulose backbone chain kunye ne-hydroxypropyl kunye ne-methyl substituents.
Olu hlengahlengiso luphucula ukunyibilika kwayo, uzinzo, kunye nokusebenza kwizicelo ezahlukeneyo.
2. Iipropati ze-HPMC:
I-HPMC ibonisa iipropati ezinjengokuqina, ukwenza ifilimu, ukubopha, ukuzinzisa, kunye nokugcinwa kwamanzi.
Yenza izisombululo ezicacileyo, ezingenambala kunye ne-viscosity ephezulu, igalelo kuthungo olufunwayo kunye nokubonakala kumanzi okuhlamba izitya.
Isakhono sokwenza ifilimu ye-HPMC inceda ekudaleni umaleko okhuselayo kumphezulu, inceda ekususeni igrisi kunye nokukhusela isitya.
B.Imisebenzi ye-HPMC kuLulwelo lokuhlambela izitya:
1. Ukutyeba kunye noLawulo lweViscosity:
I-HPMC isebenza njenge-arhente yokutyebisa, iphucula i-viscosity yolwelo lokuhlamba izitya.
I-viscosity elawulwayo iqinisekisa ukusabalalisa okufanayo kwezithako ezisebenzayo, ukuphucula ukusebenza kwemveliso kunye namava omsebenzisi.
2. Ukunqunyanyiswa kunye nokuzinziswa:
Kumanzi okuhlamba izitya, i-HPMC inceda ukumisa amasuntswana anganyibilikiyo, ukuthintela ukuzinzisa kunye nokuqinisekisa ukufana kwemveliso.
Izinzisa ukuqulunqwa ngokuchasene nokuhlukana kwesigaba kwaye igcina ukuhambelana kwemveliso ngexesha.
3. Ukwenziwa komboniso bhanyabhanya kunye noCoco lokuSebenza:
I-HPMC inegalelo ekwenziweni kwefilimu ebhityileyo kwindawo yesitya, inceda ekususeni umhlaba kunye nokuthintela ukubuyiswa kwakhona kwamasuntswana okutya.
Le filimu iphinda iphucule isenzo samanzi, ikhuthaza ukomisa ngokukhawuleza kunye neziphumo ezingenayo indawo.
C. Inkqubo yokuVelisa ye-HPMC:
1. Ukufumana izinto ezikrwada:
Imveliso ye-HPMC iqala ngokufumana i-cellulose evela kwintlama yomthi okanye imicu yomqhaphu.
I-cellulose ifumana unyango lwekhemikhali ukwazisa i-hydroxypropyl kunye namaqela e-methyl, ivelisa i-HPMC.
2. Ukuguqulwa kunye nokuCoca:
Ukuphendulwa kweekhemikhali ezilawulwayo phantsi kweemeko ezithile kukhokelela ekuguquleni i-cellulose kwi-HPMC.
Iinkqubo zokucoca ziqinisekisa ukususwa kokungcola kunye nokulungelelaniswa kobunzima bemolekyuli kunye ne-viscosity ye-HPMC.
3. Udibaniso loqulunqo:
Abavelisi badibanisa i-HPMC kulwelo lokuvasa izitya ngexesha lokudibanisa.
Ulawulo oluchanekileyo lokugxila kwe-HPMC kunye nokusabalalisa ubungakanani besuntswana kubalulekile ekufezekiseni ukusebenza kwemveliso efunekayo.
D. IMpembelelo yokuSingqongileyo kunye neNgqwalasela yoZinzo:
1. I-Biodegradability:
HPMC ithathwa biodegradable phantsi kweemeko ezifanelekileyo, ukudiliza phantsi byproducts engenabungozi ekuhambeni kwexesha.
Nangona kunjalo, izinga lokuthotywa kwebhayoloji linokwahluka ngokuxhomekeke kwimiba yokusingqongileyo kunye nobunzima bokwenziwa.
2. Ukusetyenziswa koMthombo oVuselelwayo:
Iselulosi, eyona imathiriyeli ekrwada ye-HPMC, ithathwe kwimithombo ehlaziyekayo efana nomthi kunye nomqhaphu.
Izenzo zamahlathi ezizinzileyo kunye nokufunwa okunoxanduva kunegalelo kwiziqinisekiso zokusingqongileyo ze-HPMC.
3. ULawulo lokuLahla neNkunkuma:
Iindlela ezifanelekileyo zokulahla, kubandakanywa ukurisayikilishwa kunye nokwenza umgquba, kunokunciphisa impembelelo yokusingqongileyo yeemveliso ezine-HPMC.
Amaziko aneleyo okucocwa kwamanzi amdaka anokususa ngokufanelekileyo iintsalela ze-HPMC kumdaka, kuncitshiswe imingcipheko yendalo nokuNqatshelwa kweMpilo noKhuseleko:
1. Ukuthotyelwa koMgaqo:
I-HPMC esetyenziswa kulwelo lokuhlambela izitya kufuneka ihambelane nemigangatho yolawulo ebekwe ngabasemagunyeni abafana ne-FDA (uLawulo lokuTya kunye neziyobisi) kunye ne-EPA (i-Arhente yoKhuseleko lokuSingqongileyo).
Amanyathelo okulawula umgangatho ongqongqo aqinisekisa ukhuseleko lwemveliso kunye nokubambelela kwimida evumelekileyo yokungcola.
2. Ubuthathaka bolusu kunye nokucaphuka:
Ngelixa i-HPMC ngokubanzi ithathwa njengekhuselekile ukusetyenziswa kwiimveliso zasekhaya, abantu abanolusu olubuthathaka banokufumana ukucaphuka kancinci.
Iindlela zokuphatha ezichanekileyo kunye nokusetyenziswa kwezixhobo zokukhusela zomntu (i-PPE) ngexesha lokuvelisa ukunciphisa umngcipheko onokuthi ube khona.
3. Ukuphefumla kunye neeNgozi zoMngcipheko:
Ukuphefumla uthuli lwe-HPMC okanye i-aerosols kufuneka kuncitshiswe ukuthintela ukucaphuka kokuphefumla.
Ukungena komoya okwaneleyo kunye nolawulo lobunjineli kumaziko okuvelisa kunceda ukunciphisa umngcipheko wokuvezwa kubasebenzi.
I-HPMC idlala indima eninzi ekuxutyweni kolwelo, igalelo kulawulo lwe-viscosity, ukuzinza, ukucoca ukusebenza, kunye nokuhambelana kokusingqongileyo.Iipropati zayo eziguquguqukayo, ezidityaniswa nezenzo zokukhangela ezizinzileyo kunye nokuthotyelwa kwemithetho, igxininisa ukubaluleka kwayo kwiimveliso zanamhlanje zokucoca izindlu.Njengoko abathengi besanda ukubeka phambili ukusebenza kakuhle, ukhuseleko, kunye nozinzo, indima ye-HPMC kulwelo lokuhlamba izitya ilungele ukuguquka, ukuqhuba ukutsha kunye nokuphuculwa okuqhubekayo kwimiqulu yemveliso.
Ixesha lokuposa: Mar-06-2024