IHydroxypropylmethylcellulose (HPMC) yipolymer eguquguqukayo esetyenziswa kumashishini ahlukeneyo, kubandakanywa amayeza, ulwakhiwo, ukutya, kunye nezinto zokuthambisa.Esinye sezicelo zayo eziqhelekileyo kukuqulunqwa kweemveliso zegel.Iigels ziinkqubo ze-semisolid ezineempawu ezizodwa ze-rheological, kwaye ukusebenza kwazo kunokuchaphazeleka ngezinto ezahlukeneyo, kubandakanywa nobushushu.
ukwazisa
I-Hydroxypropylmethylcellulose (HPMC) yi-cellulose ephuma kwi-cellulose eyenziwa ngokunyanga i-cellulose nge-propylene oxide kunye ne-methyl chloride.Yeyosapho lwe-cellulose ether kwaye ineempawu ezinyibilikayo emanzini kunye ne-gelling.I-HPMC isetyenziswa kakhulu kumashishini amayeza, ukutya, ulwakhiwo kunye nezithambiso ngenxa yobuchule bayo obugqwesileyo bokwenza ifilim, ukujiya kunye nejelling.
Gelation of HPMC
I-Gelation yinkqubo apho i-liquid okanye i-sol iguqula ibe yijeli, i-semi-solid state eneempawu zolwelo kunye neziqinileyo.Iijeli ze-HPMC ngokusebenzisa umatshini wokugalela amanzi kunye nokwakheka komnatha omacala amathathu.Inkqubo ye-gelation ichaphazelekayo yizinto ezifana nokugxininiswa kwe-polymer, ubunzima be-molecular kunye nobushushu.
Ukuxhomekeka kobushushu be-gelation
Ubushushu budlala indima ebalulekileyo ekuziphatheni kwe-gelation ye-HPMC.Ubudlelwane phakathi kobushushu kunye ne-gelation bunokuba nzima, kwaye kubalulekile ukuqonda ukuba utshintsho kwiqondo lokushisa luchaphazela njani iipropati zejeli ze-HPMC.Ngokubanzi, i-gelation ye-HPMC yinkqubo ye-exothermic, oku kuthetha ukuba ikhupha ubushushu.
1. Isishwankathelo seejeli ze-thermal
I-Thermal gelation curves ye-HPMC ibonakaliswe ngoluhlu lobushushu be-gelation, okt uluhlu lobushushu apho utshintsho lwe-sol ukuya kwijeli lwenzeka.Ubushushu be-gelation buchaphazeleka kukugxininiswa kwe-HPMC kwisisombululo.Uxinzelelo oluphezulu lukhokelela kubushushu obuphezulu be-gelling.
2. Impembelelo kwi-viscosity
Ubushushu buchaphazela i-viscosity yesisombululo se-HPMC kwaye ngaloo ndlela inkqubo ye-gelation.Njengoko iqondo lokushisa linyuka, i-viscosity yesisombululo se-HPMC iyancipha.Ukunciphisa i-viscosity kuchaphazela i-gel dynamics kunye neempawu zokugqibela ze-gel.Ukushisa kufuneka kulawulwe ngokucophelela kwaye kubekwe iliso ngexesha lokuqulunqa ukufezekisa i-viscosity efunwayo kunye neempawu ze-gel.
Izinto ezichaphazela ukushisa kwejeli
Izinto ezininzi zinefuthe kubushushu bejeli ye-HPMC, kwaye ukuqonda ezi zinto zibalulekile kubaqulunqi kunye nabaphandi.
1. Ukugxininiswa kwePolymer
Ukuxinwa kwe-HPMC kwifomula yinto ephambili echaphazela ukushisa kwe-gelation.Uxinzelelo oluphezulu lukhokelela kubushushu obuphezulu be-gelation.Obu budlelwane bubalelwa kukwanda kwenani lamatyathanga epolymer akhoyo kunxibelelwano lwe-intermolecular, okukhokelela kuthungelwano lwejeli olomeleleyo.
2. Ubunzima bemolekyuli ye-HPMC
Ubunzima bemolekyuli ye-HPMC nayo ichaphazela i-gelation.Ubunzima bemolekyuli obuphezulu HPMC inokubonisa amaqondo obushushu ejeli ahlukeneyo xa kuthelekiswa nobunzima obuphantsi bemolekyuli HPMC.Ubunzima bemolekyuli buchaphazela i-solubility yepolymer, i-chain entanglement, kunye namandla enethiwekhi yejeli eyenziwe.
3. Izinga lokusa amanzi
Izinga le-HPMC lokusa amanzi lichatshazelwa bubushushu.Amaqondo obushushu aphezulu akhawulezisa inkqubo ye-hydration, okukhokelela kwi-gelation ekhawulezayo.Oku kubaluleke ngakumbi kwiifom zexesha-ezifuna i-gelation ngokukhawuleza.
4. Ubukho bezongezo
Ubukho bezongezo ezifana neplastiki okanye iityuwa zinokutshintsha ubushushu be-gelling ye-HPMC.Ezi zongezo zinokusebenzisana kunye neentambo zepolymer, ezichaphazela amandla abo okwenza amanethiwekhi ejeli.Abaqulunqi kufuneka baqwalasele ngononophelo umphumo wezongezo kwindlela yokuziphatha yejeli.
Ukubaluleka okusebenzayo kunye nezicelo
Ukuqonda ukuziphatha kwejeli exhomekeke kubushushu beHPMC kubalulekile ekuqulunqeni iimveliso ezinomgangatho ongaguqukiyo kunye nokusebenza.Olu lwazi luvelisa iziphumo ezininzi ezisebenzayo kunye nokusetyenziswa.
1. Amachiza akhululayo alawulwayo
Kumashishini axuba amayeza, i-HPMC iqhele ukusetyenziswa kwimixube yeyeza elilawulwayo.Ubushushu beqondo lobushushu beejeli ze-HPMC zingasetyenziselwa ukulawula ukukhutshwa kwezithako ezisebenzayo zamayeza.Ngokuhlengahlengisa ngononophelo ubushushu be-gelation, abaqulunqi banokwenza iiprofayili zokukhupha ichiza.
2. Ii-hydrogels eziphendula ubushushu
Ubuntununtunu bobushushu be-HPMC buyenza ilungele ukuphuhliswa kwee-hydrogels eziphendula ubushushu.Ezi hydrogels zinokungena kwinguqu eguqukayo ye-sol-gel ekuphenduleni utshintsho kwiqondo lobushushu, ibenze baxabiseke kwizicelo ezifana nokuphiliswa kwesilonda kunye nokuhanjiswa kweziyobisi.
3. Izinto zokwakha
Kushishino lokwakha, i-HPMC isoloko isetyenziswa njengesongezo kwizinto ezisekwe kwisamente ukuphucula ukusebenza kunye nokugcinwa kwamanzi.Ubuntununtunu lobushushu of HPMC kuchaphazela ukusetwa ixesha kunye neempawu rheological ezi zinto, ngaloo ndlela kuchaphazela ukusebenza kwazo ngexesha lokwakha.
Imingeni kunye nezisombululo
Ngelixa ukuziphatha kwejeli exhomekeke kubushushu beHPMC inika iingenelo ezizodwa, ikwabeka imingeni kwizicelo ezithile.Ngokomzekelo, ukufezekisa iipropati zejeli ezihambelanayo kunokuba ngumngeni ekuqulunqweni apho utshintsho lweqondo lokushisa luqhelekileyo.Abaqulunqi kufuneka baqwalasele le mingeni kwaye baphumeze izicwangciso-qhinga zokuyilungisa.
1. Ukulawula ubushushu ngexesha lokulungiselela
Ukuqinisekisa ukusebenza kwakhona kwejeli, ulawulo olungqongqo lobushushu ngexesha lokuqulunqa lubalulekile.Oku kunokubandakanya ukusebenzisa izixhobo zokuxuba ezilawulwa ngubushushu kunye nokubeka iliso kwiqondo lokushisa kulo lonke uqulunqo.
2. Ukukhethwa kwepolymer
Kubalulekile ukukhetha ibakala elifanelekileyo le-HPMC kunye neempawu zobushushu ezifunekayo zejeli.Amabanga ahlukeneyo e-HPMC ayafumaneka ngobunzima beemolekyuli ezahlukeneyo kunye namanqanaba okutshintsha, evumela abaqulunqi ukuba bakhethe i-polymer eyona ifanele isicelo sabo esithile.
3. Ukulungiselela okongeziweyo
Ubukho bezongezo buchaphazela ubushushu be-gelling ye-HPMC.Umfaki-fomula unokufuna ukwandisa uhlobo kunye noxinzelelo lwezongezo ukufezekisa iipropati ezifunwayo zejeli.Oku kufuna indlela ecwangcisiweyo kunye nokuqonda ngokucokisekileyo intsebenziswano phakathi kwe-HPMC kunye nezongezo.
I-Hydroxypropylmethylcellulose (HPMC) i-polymer esebenzayo eneempawu zejeli ezizodwa ezichatshazelwa bubushushu.I-gelation exhomekeke kubushushu be-HPMC ineempembelelo ezibalulekileyo kumashishini amaninzi aquka amayeza, ulwakhiwo, kunye nezinto zokuthambisa.Ukuqonda izinto ezichaphazela ukushisa kwe-gelation, ezifana nokugxininiswa kwe-polymer, ubunzima be-molecular, kunye nobukho bezongezo, kubalulekile kubaqulunqi abafuna ukunyusa ukusebenza kwejeli kwizicelo ezithile.
Njengoko ukuqhubela phambili kwetekhnoloji kunye nophando lwesayensi yepolymer luqhubela phambili, ukuqonda ngakumbi indlela yokuziphatha exhomekeke kubushushu be-HPMC kunokukhokelela kuphuhliso lweendlela ezintsha kunye nokusetyenziswa.Ukukwazi ukulungisa kakuhle iipropati zejeli kuvula amathuba amatsha oyilo lwemathiriyeli eneempawu ezilungelelanisiweyo, ukunceda ukuqhubela phambili ekuhanjisweni kweziyobisi, i-biomaterials kunye nezinye iinkalo.
Ixesha lokuposa: Jan-11-2024