1. Intshayelelo ngeHydroxyethyl Cellulose (HEC):
I-Hydroxyethylcellulose iphuma emanzini kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zezityalo.Ukuguqulwa kwe-cellulose kunye namaqela e-hydroxyethyl kwandisa ukunyibilika kwayo emanzini kwaye inika iipropati ezithile kwi-HEC, okwenza i-HEC ibe yinto ebalulekileyo kwiintlobo ezahlukeneyo zezicelo.
2. Ubume be-HEC:
Isakhiwo se-HEC sithathwe kwi-cellulose, i-polysaccharide yomgca ehlanganiswe ngokuphindaphindiweyo kweeyunithi ze-glucose ezidityaniswe ngamabhondi e-β-1,4-glycosidic.Amaqela e-Hydroxyethyl angeniswa kwi-cellulose backbone ngokusabela kwe-etherification.I-Degree of substitution (DS) ibhekisa kwi-avareji yenani lamaqela e-hydroxyethyl ngeyunithi ye-glucose kwaye ichaphazela ukunyibilika kunye ne-viscosity ye-HEC.
3. Iimpawu ze-HEC:
A. Ukunyibilika kwamanzi: Enye yezinto eziphambili ze-HEC kukunyibilika kwayo okuphezulu kwamanzi, okubangelwa kukutshintshwa kwe-hydroxyethyl.Le propati yenza kube lula ukuqulunqa izisombululo kunye ne-dispersions ezifanelekileyo kwiintlobo ezahlukeneyo zezicelo.
b.Ubuchule bokutyebisa: I-HEC yamkelwa ngokubanzi ngeempawu zayo zokujiya kwizisombululo ezinamanzi.Xa ihlakazekile emanzini, yenza i-gel ecacileyo kunye ne-viscous, eyenza ifaneleke kwizicelo ezifuna ukulawulwa kwe-viscosity.
C. pH Ukuzinza: I-HEC ibonisa ukuzinza phezu koluhlu olubanzi lwe-pH, okwenza ukuba luhambelane nokuqulunqwa kwiindawo zombini ze-acidic kunye ne-alkaline.
d.Ukuzinza kobushushu: Izisombululo ze-HEC zihlala zizinzile kuluhlu olubanzi lobushushu.Banokuhamba ngeendlela ezininzi zokufudumeza kunye nokupholisa ngaphandle kotshintsho olubalulekileyo kwi-viscosity okanye ezinye iipropathi.
e.Ukuqulunqwa kwefilimu: I-HEC inokwenza iifilimu eziguquguqukayo kunye nezicacileyo ezifanelekileyo kwizicelo ezifana neengubo, i-adhesives kunye neefilimu.
F. Umsebenzi womphezulu: I-HEC ineempawu ezifana ne-surfactant, enenzuzo kwizicelo ezifuna ukulungiswa komphezulu okanye ukuzinziswa.
4.Ukwenziwa kwe-HEC:
I-synthesis ye-HEC ibandakanya ukusabela kwe-etherification ye-cellulose kunye ne-ethylene oxide phambi kwe-alkaline catalyst.Ukusabela kunokulawulwa ukuphumeza iqondo elifunekayo lokutshintsha, ngaloo ndlela kuchaphazela iimpawu zokugqibela zemveliso yeHEC.I-Synthesis idla ngokuqhutywa phantsi kweemeko ezilawulwayo ukuqinisekisa ukuhambelana kwemveliso kunye nomgangatho.
5. Ukusetyenziswa kwe-HEC:
A. Iipeyinti kunye neeCoatings: I-HEC isetyenziswa ngokubanzi njenge-thickener kwiipeyinti ezisekelwe emanzini kunye neengubo.Iphucula i-rheology, iphucula i-brushability, kwaye igalelo ekuqulunqweni kozinzo.
b.Iimveliso zokhathalelo lomntu: I-HEC sisithako esiqhelekileyo kwiimveliso zokhathalelo lomntu ezifana neshampu, iiloshini kunye neekhrimu.Isebenza njenge-thickener, i-stabilizer kunye ne-agent-forming agent, iphucula ukusebenza ngokubanzi kwezi zakhiwo.
C. Pharmaceutical: Kwishishini lamachiza, i-HEC isetyenziselwa ukwakhiwa komlomo kunye neengqungquthela.Ingasebenza njenge-binder, disintegrant, okanye i-matrix yangaphambili kwi-tablet formulations, kunye ne-viscosity modifier kwi-topical gels kunye ne-creams.
d.Izinto zokwakha: I-HEC isetyenziswa kwishishini lokwakha njenge-arhente yokugcina amanzi kwi-samente-based formulations.Iphucula ukusebenza kolwakhiwo, yandisa ixesha elivulekileyo, kwaye iphucula ukuncamatheliswa kweetayile zokuncamathelisa kunye nodaka.
e.Ishishini le-oyile negesi yegesi: I-HEC isetyenziswa kwishishini leoli kunye negesi njenge-ejenti yokuqinisa ulwelo lokomba.Inceda ukulawula i-viscosity kwaye ibonelela ngeempawu zokumisa ukuthintela amaqhekeza ukuba angahlali.
F. Ishishini lokutya: I-HEC isetyenziswa kwishishini lokutya njenge-thickener, i-stabilizer kunye ne-gelling agent kwiimveliso ezahlukeneyo, kubandakanywa iisosi, ii-dressings kunye needessert.
6. Iingqwalasela zolawulo:
I-HEC ngokuqhelekileyo ibonwa njengekhuselekile (i-GRAS) ngamaqumrhu alawulayo kwaye ukusetyenziswa kwayo kwiintlobo ezahlukeneyo zezicelo kulawulwa ukuqinisekisa ukhuseleko lwabathengi kunye nokusebenza kakuhle kwemveliso.Abavelisi kufuneka bathobele imimiselo yengingqi kwaye bafumane imvume efunekayo kwizicelo ezithile.
7. Iintsingiselo zexesha elizayo kunye nezinto ezintsha:
Uphando oluqhubayo lujolise ekuphuhliseni izinto eziphuma kwi-HEC ezilungisiweyo ezineempawu eziphuculweyo zezicelo ezithile.Kukwakho nogxininiso olwandayo ekuqaliseni izinto ezintsha ekufumaneni izinto ezizinzileyo kunye neendlela zokuvelisa ukujongana nemiba yokusingqongileyo nokukhuthaza ezinye iindlela ezinokuthi zikhuseleke kokusingqongileyo.
IHydroxyethylcellulose (HEC) yipolymer eguquguqukayo, eguquguqukayo eneempawu ezizodwa ezifana nokunyibilika kwamanzi, amandla okuqina, kunye nokuzinza kobushushu.Ukusuka kwiipeyinti kunye neengubo ukuya kumashishini amayeza kunye nokutya, i-HEC idlala indima ebalulekileyo ekuphuculeni ukusebenza kweemveliso ezahlukeneyo.Njengoko uphando kunye nophuhliso luqhubeka, i-HEC kusenokwenzeka ukuba ihlale ingumdlali ophambili kumashishini ahlukeneyo, inegalelo ekuphuculweni kwezinto kunye nokwakhiwa.
Ixesha lokuposa: Dec-29-2023