HPMC bakeng sa ho emisoa ha sehlopha sa meriana

Hydroxypropyl methylcellulose (HPMC) ke polymer e sebelisoang haholo indastering ea meriana, haholo-holo bakeng sa thepa ea eona ho lokiseng ho emisoa.HPMC ke ether e qhibilihang ka metsing, e seng ea ionic cellulose e nkiloeng ho selulose ea tlhaho.Ke polima e bolokehileng, e lumellanang le biodegradable e sebelisetsoang ho ntlafatsa botsitso, thepa ea rheological, le bioavailability ea ho emisoa ha meriana.Sehloohong sena, re tla tšohla thepa le ts'ebeliso ea HPMC ho emisoa ha maemo a meriana.

Thepa ea HPMC

HPMC ke semi-synthetic polymer e nkiloeng ho selulose.E na le thepa e 'maloa e etsang hore e loketse ho sebelisoa ho emisoa ha meriana.Lintho tsena li kenyelletsa:

Ho qhibiliha ha metsi: HPMC e qhibiliha haholo ka metsing, ho bolelang hore e ka qhibiliha habonolo metsing le litharollo tse ling tse nang le metsi.Sena se etsa hore ho be bonolo ho kenyelletsa ho emisoa ha meriana.

Boitšoaro ba pseudo-polasetiki: HPMC e bonts'a boits'oaro ba pseudo-plastiki, ho bolelang hore ke thixotropic ebile ke ho kuta.Thepa ena e e lumella ho fokotsa viscosity ea ho emisoa ha e le tlas'a khatello ea ho kuta, e leng ho nolofalletsang ho tsamaisa ho emisoa.

Bokhoni ba ho etsa lifilimi: HPMC e na le bokhoni bo botle ba ho etsa filimi, e bolelang hore e ka etsa lera le sireletsang holim'a likaroloana tse emisitsoeng, tse thusang ho li sireletsa ho senyeha le ho bokellana.

Mucoadhesive properties: HPMC e na le thepa ea mucoadhesive, e bolelang hore e ka khomarela bokaholimo ba mucosal 'meleng.Thepa ena e bohlokoa haholo bakeng sa lits'ebetso tsa phepelo ea lithethefatsi tsa molomo le linko, kaha e lumella nako e telele ea ho ikopanya le bokaholimo ba mucosal le ho monya lithethefatsi ho ntlafalitsoeng.

Tšebeliso ea HPMC ho Pharmaceutical Grade Suspensions

HPMC e sebelisoa mefuteng e fapaneng ea ho emisoa ha maemo a meriana.Tse ling tsa litšebeliso tse atileng haholo tsa HPMC ho emisoa ha meriana li kenyelletsa:

Ho tsitsisa: HPMC e sebelisetsoa ho ntlafatsa botsitso ba ho emisoa ha meriana.E ka thusa ho thibela particle aggregation, flocculation, le sedimentation, e ka ntlafatsang bophelo ba raka ea ho fanyeha.

Phetoho ea Rheological: HPMC e ka sebelisoa ho fetola thepa ea rheological ea ho emisoa ha meriana.E ka thusa ho fokotsa viscosity ea ho emisoa, e ka etsang hore ho be bonolo ho tsamaisa ho emisoa.

Tokollo e laoloang: HPMC e ka sebelisoa ho fihlela tokollo e laoloang ea lithethefatsi ho tsoa ho emisoa ha meriana.Bokhoni ba ho etsa filimi ea HPMC bo e lumella ho etsa lera le sireletsang holim'a likaroloana tsa lithethefatsi, tse ka liehisang ho lokolloa ha moriana 'meleng.

Ntlafatso ea bioavailability: HPMC e ka ntlafatsa bioavailability ea lithethefatsi ho emisoa ha meriana.Thepa ea mucoadhesive ea HPMC e e lumella ho khomarela bokaholimo ba mucosal 'meleng, e ka ntlafatsang ho monya ha lithethefatsi le bioavailability.

Latsoa masking: HPMC e ka sebelisoa ho pata tatso e sa thabiseng ea lithethefatsi ho emisoa ha meriana.Bokhoni ba ho etsa filimi ea HPMC bo e lumella ho etsa lera le sireletsang ho pota-potile likaroloana tsa lithethefatsi, tse ka thibelang ho lokolloa ha moriana molomong le ho pata tatso ea eona.

Ntlafatso ea tumellano: HPMC e ka ntlafatsa tšebelisano ea lithethefatsi ho emisoa ha meriana.Sebopeho se qhibilihang ka metsi sa HPMC se e lumella ho qhibiliha ka metsing le litharollo tse ling tse nang le metsi, tse ka ntlafatsang ho lumellana ha moriana le lisebelisoa tse ling ha ho emisoa.

Qetello

HPMC ke polymer e feto-fetohang e sebelisoang haholo indastering ea meriana bakeng sa thepa ea eona ho lokiseng ho emisoa.Ho qhibiliha ha eona ha metsi, boits'oaro ba pseudo-polasetiki, bokhoni ba ho etsa lifilimi, thepa ea ho khomarela li-mucoadhesive, le biocompatibility e etsa hore e be polima e molemo bakeng sa ho tsitsisa ho emisoa ha meriana.