Hydroxypropylmethylcellulose (HPMC) ipolymer inotorwa kubva muselulosi iyo inowanzoshandiswa mumaindasitiri akasiyana siyana, anosanganisira emishonga, chikafu, uye kuvaka.Tembiricha inogona kuve yakakosha pakuita kweHPMC uye maitiro.
1. Solubility uye kupera:
Solubility: HPMC inoratidza tembiricha-inotsamira solubility.Kazhinji, inonyungudika mumvura inotonhora kupfuura mumvura inopisa.Ichi chivakwa chakakosha pakugadzirwa kwemishonga kunoda kuburitswa kwemishonga.
Dissolution: Mwero wekuparara kweHPMC maumbirwo anokonzerwa nekupisa.Kupisa kwepamusoro kunowanzo tungamira mukuparara nekukurumidza, nekudaro zvichikanganisa kuburitsa zvinodhaka kinetics mukushandisa kwemishonga.
2. Gelation uye viscosity:
Gelation: HPMC inogona kuumba gel mune aqueous mhinduro, uye gelation muitiro kukanganiswa tembiricha.Gelation inowanzosimudzirwa pakupisa kwepamusoro, zvichiita kuti pave nekugadzikana kwejeri network.
Viscosity: Tembiricha inoita basa rakakosha pakuona viscosity yeHPMC mhinduro.Kazhinji kutaura, kuwedzera kwekushisa kunokonzera kuderera kwe viscosity.Ichi chivakwa chakakosha pakugadzira machira, zvinonamira uye zvimwe zvinoshandiswa zvinoda viscosity control.
3. Magadzirirwo emufirimu:
Firimu coating: Muindasitiri yemishonga, HPMC inoshandiswa zvakanyanya kupfekedza firimu remapiritsi.Tembiricha inokanganisa iyo firimu-inogadzira zvimiro zveHPMC mhinduro.Kupisa kwepamusoro kunogona kusimudzira maitiro ekugadzira firimu uye kukanganisa kunaka uye maitiro eiyo firimu yekuputira.
4. Thermal kugadzikana:
Degradation: HPMC inoratidza kugadzikana kwekupisa mukati meimwe tembiricha renji.Kupfuura chiyero ichi, kupisa kwemafuta kunogona kuitika, zvichikonzera kurasikirwa kweviscosity uye zvimwe zvinodiwa.Kugadzikana kwekupisa kweHPMC kunofanirwa kutariswa mune akasiyana maapplication.
5. Phase shanduko:
Glass Transition Temperature (Tg): HPMC inopinda girazi shanduko pane imwe tembiricha inonzi tembiricha yegirazi (Tg).Pamusoro peTg, iyo polymer shanduko kubva kune girazi kuenda kune yerubhai, inokanganisa ma mechanika ayo.
6. Kudyidzana kweDrug-Polymer:
Complex Formation: Mukugadzirwa kwemishonga, tembiricha inokanganisa kudyidzana pakati peHPMC nemushonga.Kuchinja kwekushisa kunogona kutungamira mukuumbwa kwemacomplexes, zvichikanganisa kunyungudika kwezvinodhaka uye kusunungurwa.
7. Formula kugadzikana:
Freeze-Thaw Stability: HPMC inowanzoshandiswa mukugadzirwa kwechando, senge madhirita akaomeswa nechando.Kugadzikana kwayo panguva yechando-thaw cycles kunokonzerwa nekushanduka kwekushisa.Kunzwisisa mhedzisiro yekushisa kwakakosha kuchengetedza kunaka kwechigadzirwa.
Tembiricha ine mhedzisiro yakakosha pakunyungudika, kunyungudika, gelation, viscosity, kuumbwa kwemafirimu, kugadzikana kwekupisa, shanduko yechikamu, kupindirana kwezvinodhaka-polymer, uye kugadzikana kwekugadzirisa kweHPMC.Vatsvagiri uye vanogadzira vanofanirwa kunyatso funga izvi zvine chekuita nekupisa kana uchishandisa HPMC mumhando dzakasiyana dzekushandisa.
Nguva yekutumira: Jan-20-2024