Pharmaceutical qib HPMC E50

Hydroxypropyl methylcellulose (HPMC) yog cov khoom siv dav siv polymer hauv kev lag luam kws tshuaj.HPMC yog cov dej-soluble, uas tsis yog-ionic cellulose derivative uas yog muab los ntawm cellulose.Cov khoom ntawm HPMC tuaj yeem tswj tau los ntawm qhov sib txawv ntawm qhov hloov pauv (DS), qib ntawm polymerization (DP), thiab qhov piv ntawm hydroxypropyl rau methyl hloov.HPMC E50 yog qib HPMC nrog DS ntawm 0.5 thiab viscosity ntawm 50 cps ntawm 20 ° C.

HPMC E50 feem ntau yog siv los ua tus excipient hauv kev lag luam kws tshuaj vim nws cov khoom tshwj xeeb.Ib qho txiaj ntsig tseem ceeb ntawm HPMC E50 yog nws lub peev xwm los tsim cov gels ntawm qhov tsis tshua muaj siab.Cov cuab yeej no ua rau nws zoo heev thickener thiab binder nyob rau hauv ntau yam formulations.HPMC E50 kuj tseem ruaj khov nyob rau hauv muaj cov kua qaub, cov hauv paus, thiab ntsev, uas ua rau nws yog ib tus neeg sib tw zoo tshaj plaws rau kev siv ntau yam ntawm pH.

Ntxiv rau nws cov thickening thiab khi cov khoom, HPMC E50 kuj yog ib zaj duab xis zoo qub.Cov cuab yeej no ua rau nws yog qhov kev xaiv zoo tshaj plaws rau kev siv hauv daim ntawv thov txheej txheej.Zaj duab xis txheej tuaj yeem siv los txhim kho qhov tsos, saj, thiab kev ruaj ntseg ntawm cov ntaub ntawv ntawm qhov ncauj.HPMC E50 feem ntau yog siv los ua tus neeg ua yeeb yaj kiab hauv cov txheej txheej enteric, uas yog tsim los tiv thaiv cov tshuaj los ntawm acidic ib puag ncig ntawm lub plab thiab tso tawm lawv nyob rau hauv ntau alkaline ib puag ncig ntawm cov hnyuv me.

Lwm yam khoom tseem ceeb ntawm HPMC E50 yog nws solubility hauv dej.HPMC E50 yog soluble hauv dej thiab ua kom pom tseeb, tsis muaj xim.Cov cuab yeej no ua rau nws yog qhov kev xaiv zoo tshaj plaws rau kev siv hauv cov ntaub ntawv ua kua xws li kev ncua thiab kev daws teeb meem.HPMC E50 kuj tseem siv tau los tswj kev tso tawm cov tshuaj los ntawm cov ntaub ntawv siv ntau npaum li cov ntsiav tshuaj thiab tshuaj ntsiav.Los ntawm kev sib txawv ntawm qhov concentration ntawm HPMC E50, qhov tso tawm ntawm cov tshuaj tuaj yeem tswj tau.

Ntxiv nrog rau kev siv hauv kev lag luam tshuaj, HPMC E50 kuj tseem siv rau ntau yam kev siv.HPMC E50 yog siv rau hauv kev lag luam khoom noj khoom haus ua cov thickener, stabilizer, thiab emulsifier.Nws kuj yog siv rau hauv kev tsim kho kev lag luam raws li ib tug binder thiab thickener nyob rau hauv cement-based khoom.

Thaum siv HPMC E50 hauv cov tshuaj formulations, nws yog ib qho tseem ceeb uas yuav tau xav txog qhov muaj peev xwm cuam tshuam nrog lwm cov excipients thiab cov khoom siv tshuaj nquag (API).HPMC E50 tuaj yeem cuam tshuam nrog lwm cov excipients, ua rau muaj kev hloov pauv hauv lub cev ntawm cov qauv.HPMC E50 tuaj yeem cuam tshuam nrog API, uas tuaj yeem cuam tshuam rau nws cov bioavailability thiab tso tawm tus nqi.Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tau ua tib zoo xav txog kev sib raug zoo ntawm HPMC E50 nrog rau lwm cov excipients thiab API ua ntej tsim ib daim ntawv ntau npaum.

Hauv kev xaus, HPMC E50 yog ntau yam polymer nrog ntau yam kev siv hauv kev lag luam tshuaj.Nws cov khoom tshwj xeeb, suav nrog nws lub peev xwm tsim cov gels, muaj peev xwm tsim cov yeeb yaj kiab, solubility hauv dej, thiab kev ruaj ntseg nyob rau hauv ntau hom pH, ua rau nws yog ib tus neeg sib tw zoo tshaj plaws rau ntau hom formulations.Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tau ua tib zoo xav txog qhov sib raug ntawm HPMC E50 nrog rau lwm cov khoom ntxiv thiab API ua ntej tsim daim ntawv ntau npaum.