Kuyini ukusetshenziswa kwamaconsi e-HPMC?

1. Izici eziyisisekelo ze-HPMC ziyehla

I-HPMC i-non-ionic cellulose ether enezinzuzo ezilandelayo:

Ukuqina okuqinile nokunamathela: kusiza ukwandisa isikhathi sokuhlala kwezidakamizwa ebusweni bezicubu zendawo.

I-biocompatibility enhle: ayicasuli, ayibangeli ukungezwani komzimba, futhi ifanele izindawo ezibucayi njengamehlo.

Okusobala nokungenambala, ukuzinza okuhle kwe-pH: kulungele ukusetshenziswa njengesithwali sokudonsa, akuphazamisi ukubona kanye nemisebenzi yomzimba.

Ukukhululwa okuzinzile: kungalawula izinga lokukhishwa kwezidakamizwa futhi kunwebe ukusebenza kahle.

Lezi zici zenza i-HPMC ibe isiza esikahle ekulungiseleleni okokwehla, ikakhulukazi ezimeni lapho ukukhululwa okuqhubekayo noma ukugcotshwa kuyadingeka.

 

2. Ukusetshenziswa okuyinhloko kwamaconsi e-HPMC

2.1. Izinyembezi zokwenziwa/izithambisi zamehlo

Lesi ngesinye sezimo zohlelo lokusebenza ezivame kakhulu zokwehla kwe-HPMC. Izinyembezi zokwenziwa zisetshenziselwa ikakhulukazi ukukhulula amehlo omile, ukukhathala kwamehlo, ukungakhululeki okubangelwa ukugqoka amalensi okuxhumana isikhathi eside, nezinye izinkinga. I-HPMC idlala indima enkulu elandelayo ekudonseni iso:

Ukulingisa izinyembezi zemvelo: I-HPMC inokugcinwa kwamanzi okuhle kakhulu kanye nokuthambisa, ingalingisa ngempumelelo umsebenzi wezinyembezi zemvelo, futhi ikhulule amehlo omile.

Ukwandisa isikhathi sokunamathela kwezidakamizwa: Ngokwenza ifilimu encane, isikhathi sokugcinwa kwesidakamizwa endaweni ye-ocular siyathuthukiswa, futhi ukusebenza kahle kuyathuthukiswa.

Ukusiza ezinye izithako: Ivamise ukusetshenziswa nezithambisi ezifana ne-PVA (i-polyvinyl alcohol) ne-PEG (i-polyethylene glycol) ukuze kuthuthukiswe umuzwa wokusetshenziswa.

Imikhiqizo evamile efana ne-"hydroxypropyl methylcellulose eye drops" kanye "ne-Runjie Artificial tears" yonke iqukethe izithako ze-HPMC.

 

2.2. I-Thickener ye-ophthalmic therapeutic eye drops

I-HPMC ayikwazi nje ukusetshenziswa njengesithambisi, kodwa futhi ivame ukusetshenziswa kumaconsi eso okwelapha, njengezidakamizwa ezilwa nokuvuvukala, ama-antibiotics, izidakamizwa ze-glaucoma, njll, ukuze:

Khulisa ukuzinza kwezidakamizwa;

Yehlisa ijubane imvume yezidakamizwa;

Yehlisa imvamisa yomthamo futhi uthuthukise ukuthobela isiguli.

Isibonelo, i-HPMC kwesinye isikhathi iyengezwa kumathonsi eso e-levofloxacin asetshenziselwa ukwelapha i-conjunctivitis ukuze kwelule isikhathi sokusebenza somuthi ku-conjunctival sac.

 

2.3. I-Otolaryngology iyancipha

Emathonsini aphuma emakhaleni nasendlebeni, i-HPMC ivamise ukusetshenziswa njenge-thickener noma i-matrix yokukhululwa okuqhubekayo kulezi zimo ezilandelayo:

Amaconsi e-Auricular anti-infective: I-HPMC isiza ukuthi umuthi uhlale endlebeni yendlebe futhi uthuthukise umphumela wendawo we-bactericidal.

I-Ninitis yehla: Impahla eqhubekayo yokukhululwa ivumela izidakamizwa ezilwa nokuvuvukala noma ezilwa nokungezwani komzimba ukuba zibe nomthelela ohlala njalo futhi zinciphise ukulahlekelwa kwezidakamizwa okubangelwa ukuguquguquka kwamakhala.

 

2.4. Amaconsi e-oral mucosal

Ekwelapheni izilonda zomlomo noma i-mucositis, ezinye izidakamizwa zenziwa amaconsi ukuze zikwazi ukuwela ngqo endaweni ye-lesion. I-HPMC inganikeza ukunamathela nokukhululwa okuqhubekayo, okuvumela umuthi ukuthi usebenze kangcono endaweni ethintekile.

 

3. Izinzuzo zokuklama kwefomu lomthamo we-HPMC eyehlayo

I-HPMC ayigcini nje ngokuba i-thickener kufomula yokudonsa, kodwa futhi iyisithwali esisebenzayo esibalulekile. Izinzuzo zayo zibonakala ku:

Ukuphepha okuphezulu: akumuncwe umzimba womuntu, akukho ubuthi obuhlelekile, obufanele ukusetshenziswa isikhathi eside.

Thuthukisa okuhlangenwe nakho kwesiguli: akukho ukucasuka, ukhululekile ukusebenzisa, ikakhulukazi iziguli ezizwelayo njengezinsana nasebekhulile.

Ukuhambisana okuhle: kungahlalisana nezinhlobonhlobo zezithako ezisebenzayo, akulula ukubangela ukusabela kokucekelwa phansi.

Kulula ukulungisa nokugcina: Amaconsi e-HPMC anokuqina okuhle nokukhanyela ekamelweni lokushisa futhi kulula ukwenza izimboni.