I-HPMC (Hydroxypropyl Methyl Cellulose)futhiI-HPC (Hydroxypropyl Cellulose)kokubili okuphuma ku-cellulose, asetshenziswa kabanzi embonini yezemithi, yokudla, yokwakha kanye nezimonyo. Nakuba lezi zibili zifana kwezinye izici, ngokusobala zihlukile ekwakhekeni kwamakhemikhali, izakhiwo ezingokomzimba nezamakhemikhali, izindawo zokuncibilika kanye nezicelo.
1. Isakhiwo samakhemikhali kanye nezakhiwo
I-HPMC yenziwe nge-methylation kanye ne-hydroxypropylation ye-cellulose yemvelo, futhi iqukethe amaqembu e-methoxy (–OCH₃) kanye ne-hydroxypropoxy (–OCH₂CHOHCH₃) ku-molecule.
I-HPC itholakala nge-hydroxypropylation ye-cellulose, futhi iqembu layo eliyinhloko elisebenzayo yi-hydroxypropoxy (–OCH₂CHOHCH₃), ngaphandle kwe-methoxy.
Ngenxa yokuthi i-HPMC iqukethe iqembu elengeziwe le-methoxy kune-HPC, i-HPMC ithi i-hydrophobic kancane, kuyilapho i-HPC ine-hydrophilic kakhulu. Ukwengeza, isisindo samangqamuzana e-HPMC sivame ukuphakama, kuyilapho isisindo samangqamuzana e-HPC singalawulwa ngokuguquguqukayo, okuthinta izici ze-solubility kanye ne-viscosity kokubili.
2. Ukuncibilika kwamanzi nezici zokuncibilika
I-HPMC incibilika emanzini abandayo ukuze yakhe isixazululo se-colloidal esobala noma eguquguqukayo, kodwa ayincibiliki emanzini ashisayo. Ngakho-ke, i-HPMC idinga ukuhlakazwa kusengaphambili noma ihlakazwe kusetshenziswa izindlela ezikhethekile kwezinye izinhlelo zokusebenza.
I-HPC inokuncibilika okuhle kwamanzi futhi ingancibilika emanzini abandayo nakwezinye izincibilikisi eziphilayo, njenge-ethanol, i-methanol, njll., futhi inezici ezinhle zokujiya nokwenza ifilimu.
I-HPMC inendawo ye-thermogel. Lapho izinga lokushisa likhuphuka, isisombululo singase sihlukane, kuyilapho i-HPC ngokuvamile ingenzi i-thermogel, ngakho-ke i-HPC inokusimama okungcono ezindaweni zokushisa okuphezulu.
3. Viscosity kanye rheological izakhiwo
I-HPMC ine-viscosity ephakeme futhi ivamise ukusetshenziswa njenge-thickener, stabilizer kanye ne-ejenti yokwakha ifilimu. Izici zayo ze-rheological kusisombululo se-aqueous ziseduze noketshezi lwe-pseudoplastic.
I-HPC ine-viscosity ephansi futhi ifaneleka kakhulu ukwakheka okudinga uketshezi olungcono, njengemithi yomlomo nezinto zokumboza.
4. Izinkambu zokufaka isicelo
Ngenxa yomehluko wezakhiwo zomzimba namakhemikhali phakathi kwe-HPMC ne-HPC, adlala izindima ezihlukene ezimbonini nasemikhiqizo ehlukene:
Imboni yezemithi
I-HPMC isetshenziswa kakhulu njenge-binder, impahla ekhishwa isikhathi eside, okokuhlanganisa ifilimu kumaphilisi emithi, nanjengengxenye yegobolondo yamaphilisi angenalutho. Isakhiwo sayo esihle sokwenza ifilimu nokuncibilika kwamanzi kuyenza ibe isisetshenziswa esikhethwayo samalungiselelo okukhishwa okuqhubekayo.
I-HPC isetshenziswa kakhulu njenge-disintegrant, binder, solubilizer, kanye ne-bioadhesive material kumathebulethi, futhi ilungele ukuthuthukisa ukunyibilika nokutholakala kwezidakamizwa. Ukwengeza, i-HPC isetshenziswa kabanzi kubuchwepheshe be-hot melt extrusion kune-HPMC.
Imboni yokudla
I-HPMC ingasetshenziswa njenge-thickener yokudla, i-emulsifier, i-stabilizer, ne-emulsifier stabilizer yokhilimu ongewona owobisi.
I-HPC isetshenziswa kakhulu njengesigqila sokudla, i-emulsifier, kanye nesithuthukisi, futhi ifanele ukudla okungenashukela nokunekhalori ephansi.
Izimonyo nokunakekelwa komuntu siqu
I-HPMC ingasetshenziswa emikhiqizweni yokunakekelwa kwesikhumba kanye nezihlanzi njenge-emulsifier stabilizer.
I-HPC ifaneleka kakhulu emikhiqizweni yokunakekelwa kwezinwele, izinto zokuthambisa kanye nemikhiqizo yokunakekelwa kwamehlo ngenxa yokuncibilika kwayo okuhle kwamanzi kanye nokuthambisa.
Izinto zokwakha
I-HPMC iyisakhi esibalulekile sezinto zokumboza zezakhiwo, osimende, nama-putty powders, abamba iqhaza ekujikeni, ekugcinweni kwamanzi nasekuthuthukiseni ukunamathela.
I-HPC ayisetshenziswa kancane embonini yezokwakha, kodwa ingasetshenziswa ezimbotsheni ezithile ezincibilika emanzini nezinamatheliso.
5. Ukuvikelwa kwemvelo nokuphepha
Kokubili i-HPMC ne-HPC zithathwe ku-cellulose yemvelo futhi zinokubola okuhle nokuphepha. I-HPMC ngokuvamile ibhekwa njengengenabo ubuthi futhi ayicunuli, kuyilapho i-HPC isetshenziswa kabanzi ekudleni nasemithini, ihlangabezana nezimfuneko zokuphepha ze-FDA (US Food and Drug Administration) namanye amazinga omhlaba.
6. Iziphakamiso zokukhetha
Uma i-viscosity ephakeme kanye nezakhiwo zokwakha ifilimu zidingeka, i-HPMC ifanelekile, njengokugcotshwa kwethebhulethi, okokuhlanganisa kwezakhiwo nezinye izinhlelo zokusebenza.
Uma kudingeka ukuncibilika okungcono kanye ne-biocompatibility, i-HPC ifanelekile, njengezidakamizwa zomlomo, izingxenye ze-hot melt extrusion, njll.
I-HPMCfuthiI-HPCkokubili okuphuma ku-cellulose okubalulekile, okuhlukile ngesakhiwo samakhemikhali, ukuncibilika, nezindawo zokusetshenziswa. I-HPMC ifaneleka kakhulu ku-viscosity ephezulu, izinhlelo zokusebenza ezishisayo zokwakha ijeli ezifana ne-tablet coating kanye nezinto zokwakha, kuyilapho i-HPC ifaneleka kakhulu ekulungiseleleni ngomlomo, izimonyo kanye nezithuthukisi zokudla ngenxa yokuncibilika kwayo okuhle kwamanzi kanye ne-viscosity ephansi. Ngokwezidingo ezithile, ukukhetha impahla efanele kungathuthukisa ukusebenza nokuzinza komkhiqizo.
Isikhathi sokuthumela: Mar-28-2025