Umgomo wokusabela we-cellulose ether hydroxypropyl methyl cellulose: ukukhiqizwa kwe-HPMC hydroxypropyl methyl cellulose kusebenzisa i-methyl chloride ne-propylene oxide njengama-etherification agents.I-chemical reaction equation ithi: Rcell-OH (ukotini ocwengekile) + NaOH (sodium hydroxide) , i-Sodium hydroxide) + CspanCl (methyl chloride) + CH2OCHCspan (propylene oxide) → Rcell-O -CH2OHCHCspan (hydroxypropyl methylcellulose) + NaCl (sodium chloride) ) + H2O (amanzi)
Ukugeleza kwenqubo:
ukucolwa ukotini okucolisisiwe—i-alkaliization—ukuphakela—i-alkalization—i-etherification—ukubuyiswa kwe-solvent nokugeza—ukuhlukaniswa kwe-centrifugal—ukumisa—ukuchoboza—ukuhlanganisa—Ukupakishwa komkhiqizo
I-1: Izinto ezisetshenziswayo kanye nezinto ezisizayo zokwenziwa kwe-hydroxypropyl methylcellulose Impahla eluhlaza eyinhloko ukotini ocolisisiwe, futhi izinto ezisizayo yi-sodium hydroxide (i-sodium hydroxide), i-propylene oxide, i-methyl chloride, i-acetic acid, i-toluene, isopropanol, ne-nitrogen.Inhloso yokuchotshozwa kukakotini ocolile ukucekela phansi uhlaka oluhlanganisiwe lukakotini ocolisisiwe ngokusebenzisa amandla omshini ukuze kuncishiswe i-crystallinity kanye ne-polymerization degree nokwandisa indawo yayo.
2: Ukulinganisa kanye nokulawulwa kwekhwalithi yezinto ezingavuthiwe: Ngaphansi kwesisekelo sezinto ezithile zokusebenza, ikhwalithi yanoma yiziphi izinto zokusetshenziswa eziyinhloko nezisizayo kanye nesilinganiso senani elingeziwe kanye nokugxila kwe-solvent kuthinta ngokuqondile izinkomba ezihlukahlukene zomkhiqizo.Uhlelo lwenqubo yokukhiqiza luqukethe inani elithile lamanzi, futhi amanzi kanye nezincibilikisi eziphilayo azihlangani ngokuphelele, futhi ukuhlakazeka kwamanzi kuthinta ukusatshalaliswa kwe-alkali ohlelweni.Uma inganyakaziswanga ngokwanele, izoba yingozi ekwenzeni i-alkalization efanayo kanye ne-etherification ye-cellulose.
3: Ukugqugquzela nokudluliswa kwenqwaba kanye nokudlulisa ukushisa: I-cellulose alkalization kanye ne-etherification konke kwenziwa ngaphansi kwezimo ezihlukahlukene (ezinyakaziswa ngamandla angaphandle).Ukuthi ukuhlakazwa nokuthintana kwamanzi, i-alkali, ukotini ocolisisiwe kanye ne-ejenti e-etherifying ohlelweni lokuncibilikisa kufana ngokwanele, kuzothinta ngqo imiphumela ye-alkalization kanye ne-etherification.Ukunyakazisa okungalingani ngesikhathi senqubo ye-alkalization kuzodala amakristalu e-alkali nemvula ngaphansi kwemishini.Ukugxila kongqimba olungaphezulu kuphansi futhi i-alkalization ayanele.Ngenxa yalokho, kusenenani elikhulu le-alkali yamahhala ohlelweni ngemva kokuqedwa kwe-etherification.Ukufana, okuholela ekukhanyeni okubi, amafayibha amahhala, ukungagcini kahle kwamanzi, indawo yejeli ephansi, nevelu engu-PH ephezulu.
4: Inqubo yokukhiqiza (inqubo yokukhiqiza udaka)
(1:) Faka inani elishiwo le-alkali eqinile (790Kg) kanye namanzi (inani eliphelele lamanzi esistimu 460Kg) eketela le-caustic soda, gudluza futhi ushise ekushiseni okungaguquki okungama-degree angu-80 imizuzu engaphezu kwengu-40, futhi i-alkali eqinile iphelele. ncibilika.
(2:) Engeza u-6500Kg we-solvent ku-reactor (isilinganiso se-isopropanol ne-toluene ku-solvent cishe ngu-15/85);cindezela i-alkali kureactor, bese ufafaza u-200Kg wento encibilikayo ethangini le-alkali ngemva kokucindezela i-alkali.Hlanza ipayipi;igedlela lokusabela lipholiswe libe ngu-23°C, bese kwengezwa ukotini ocolisisiwe ocolile (800Kg).Ngemva kokwengezwa ukotini ocolisisiwe, u-600Kg we-solvent uyafafazwa ukuze kuqalwe ukusabela kwe-alkalization.Ukwengezwa ukotini ocolile ochotshoziwe kufanele kuqedwe phakathi nesikhathi esibekiwe (imizuzu engu-7) (ubude besikhathi sokwengeza bubaluleke kakhulu).Uma ukotini ocolisisiwe uhlangana nesisombululo se-alkali, ukusabela kwe-alkalization kuyaqala.Uma isikhathi sokudla siside kakhulu, izinga le-alkalization lizohluka ngenxa yesikhathi lapho ukotini ocwengiwe ungena ohlelweni lokusabela, okuholela e-alkalization engalingani nokunciphisa ukufana komkhiqizo.Ngesikhathi esifanayo, kuzokwenza ukuthi i-cellulose ye-alkali ixhumane nomoya isikhathi eside ukuze i-oxidize futhi ihlehlise, okuholela ekunciphiseni kwe-viscosity yomkhiqizo.Ukuze uthole imikhiqizo enamazinga ahlukene e-viscosity, i-vacuum ne-nitrogen ingasetshenziswa ngesikhathi senqubo ye-alkalization, noma inani elithile le-antioxidant (i-dichloromethane) lingangezwa.Isikhathi se-alkalization silawulwa ku-120min, futhi izinga lokushisa ligcinwa ku-20-23 ℃.
(3:) Ngemva kokuba i-alkalization isiphelile, engeza inani elishiwo le-etherifying agent (methyl chloride kanye ne-propylene oxide), nyusa izinga lokushisa liye ezingeni lokushisa elishiwo futhi wenze ukusabela kwe-etherification phakathi nesikhathi esibekiwe.
Izimo ze-Etherification: 950Kg ye-methyl chloride kanye ne-303Kg ye-propylene oxide.Engeza i-etherification agent bese upholisa futhi ugovuze imizuzu engu-40 bese ukhuphula izinga lokushisa.Izinga lokushisa lokuqala le-etherification lingu-56°C, isikhathi sokushisa esingaguquki ngu-2.5h, izinga lokushisa lesibili le-etherification lingu-87°C, futhi izinga lokushisa elingaguquki lingu-2.5h.Ukusabela kwe-hydroxypropyl kungaqhubeka cishe ku-30°C, izinga lokusabela lisheshisa kakhulu ku-50°C, ukusabela kwe-methoxylation kuhamba kancane ku-60°C, futhi kuba buthaka ngaphansi kuka-50°C.Inani, ingxenye kanye nesikhathi se-methyl chloride ne-propylene oxide, kanye nokulawulwa kokukhuphuka kwezinga lokushisa kwenqubo ye-etherification, kuthinta ngokuqondile ukwakheka komkhiqizo.
Imishini ebalulekile yokukhiqiza i-HPMC i-reactor, dryer, granulator, pulverizer, njll. Njengamanje, abakhiqizi abaningi bangaphandle basebenzisa imishini ekhiqizwa eJalimane.Imishini ekhiqizwe ekhaya, noma ngabe amandla okukhiqiza noma ikhwalithi yokukhiqiza, ayikwazi ukuhlangabezana nezidingo zokukhiqizwa kwekhwalithi ephezulu ye-HPMC.
I-All-In-One Reactor ekhiqizwa e-Germany ingaqedela izinyathelo zezinqubo eziningi ngedivayisi eyodwa, ibone ukulawula okuzenzakalelayo, ikhwalithi yomkhiqizo ezinzile, nemisebenzi yokukhiqiza ephephile nethembekile.
Izinto zokusetshenziswa eziyinhloko zokukhiqizwa kwe-HPMC ukotini ocolisisiwe, i-sodium hydroxide, i-methyl chloride, ne-propylene oxide.
Isikhathi sokuthumela: Nov-11-2021