IHydroxypropyl Methylcellulose (HPMC) isetyenziswa ngokuqhelekileyo i-semi-synthetic polymer ene-biocompatibility efanelekileyo, i-non-toxicity kunye ne-viscosity ephezulu. Kwintsimi yamachiza, i-HPMC isetyenziswa ngokubanzi kwiifom ezahlukeneyo zedosi, phakathi kwazo amaconsi enye yezinto ezibalulekileyo zokusetyenziswa. I-HPMC yehla ikakhulu ibhekisa kumalungiselelo olwelo alungiselelwe nge-HPMC njengeyona arhente iphambili yokwenza ifilim okanye i-thickener. Inobambelela kakuhle, ukukhululwa okuzinzileyo kunye nokuzinza, kwaye ifanelekile kumayeza e-topical kwiindawo ezahlukeneyo ezifana ne-ophthalmology, i-otology, i-nasal cavity kunye nomlomo womlomo.
1. Iimpawu ezisisiseko ze-HPMC ziyehla
I-HPMC yi-ether ye-cellulose engeyo-ionic enezi ncedo zilandelayo:
Ukuqina okunamandla kunye nokubambelela: kunceda ukwandisa ixesha lokuhlala kweziyobisi kumphezulu wezicubu zendawo.
I-biocompatibility elungileyo: ayicaphukisi, ayibangeli ukusabela komzimba, kwaye ifanelekile kwiindawo ezinobuthathaka ezifana namehlo.
Ukungafihli kunye nombala, ukuzinza okuhle kwe-pH: ilungele ukusetyenziswa njenge-drop carrier, ayichaphazeli umbono kunye nemisebenzi ye-physiological.
Ukukhululwa okuzinzileyo: kunokulawula izinga lokukhululwa kweziyobisi kunye nokwandisa ixesha elisebenzayo.
Ezi mpawu zenza i-HPMC ibe yi-excipient efanelekileyo kumalungiselelo okwehla, ngakumbi kwiimeko apho ukukhululwa okuzinzileyo okanye ukuthanjiswa kuyadingeka.
2. Ukusetyenziswa okuphambili kwe-HPMC kwehla
2.1. Iinyembezi ezenziweyo / izithambisi zamehlo
Le yenye yeemeko zesicelo eziqhelekileyo ze-HPMC ezihlayo. Iinyembezi ezenziweyo zisetyenziselwa kakhulu ukukhulula amehlo omileyo, ukudinwa kwamehlo, ukungonwabi okubangelwa kukunxiba iilensi zexesha elide, kunye nezinye iingxaki. I-HPMC idlala indima ephambili elandelayo kumathontsi esweni:
Ukulinganisa iinyembezi zendalo: I-HPMC inokugcinwa kwamanzi okugqwesileyo kunye ne-lubricity, inokulinganisa ngokufanelekileyo umsebenzi weenyembezi zendalo, kunye nokukhulula amehlo omileyo.
Ukwandisa ixesha lokubambelela kweziyobisi: Ngokwenza ifilimu encinci, ixesha lokugcinwa kweyeza kwi-ocular surface liphuculwe, kwaye ukusebenza kuphuculwe.
Ukunceda ezinye izithako: Ihlala isetyenziswa kunye nezinto zokuthambisa ezifana ne-PVA (i-polyvinyl alcohol) kunye ne-PEG (i-polyethylene glycol) ukwandisa imvakalelo yokusetyenziswa.
Iimveliso eziqhelekileyo ezifana "ne-hydroxypropyl methylcellulose eye drops" kunye "ne-Runjie artificial tears" zonke zinezithako ze-HPMC.
2.2. Thickener for ophthalmic therapeutic eye drops iliso
I-HPMC ayinakusetyenziswa kuphela njengento yokuthambisa, kodwa isoloko isetyenziswa kumathontsi eliso lonyango, njengamachiza alwa nokudumba, amayeza okubulala iintsholongwane, amachiza eglaucoma, njl., ukuya:
Ukuphucula uzinzo kumachiza;
Ukucotha ukukhutshwa kweziyobisi;
Ukunciphisa i-dosing frequency kunye nokuphucula ukuthotyelwa kwesigulane.
Umzekelo, i-HPMC ngamanye amaxesha yongezwa kwi-levofloxacin eye drops esetyenziselwa ukunyanga i-conjunctivitis ukwandisa ixesha lesenzo sechiza kwi-conjunctival sac.
2.3. I-Otolaryngology iyancipha
Kumathontsi eempumlo kunye neendlebe ezithontsizayo, i-HPMC isoloko isetyenziswa njengento etyebisayo okanye ukukhutshwa okuzinzileyo kwematrix kwezi meko zilandelayo:
I-Auricular anti-infective drops: I-HPMC inceda ukuba ichiza lihlale kwi-canal yendlebe kwaye ikhulise umphumo we-bactericidal wendawo.
I-Ninitis yehla: Ipropati yokukhululwa eqhubekayo ivumela izidakamizwa ezichasayo okanye ezichasayo ukuba zibe nefuthe elihlala njalo kwaye zinciphise ukulahlekelwa kweziyobisi okubangelwa ukugungxula kweempumlo.
2.4. Amathontsi e-mucosal yomlomo
Kunyango lwezilonda zomlomo okanye i-mucositis, ezinye iziyobisi zenziwa ngamaconsi ukwenzela ukuba zihlanjululwe ngokuthe ngqo kwindawo ye-lesion. I-HPMC inokubonelela ngokubambelela kunye nokukhululwa okuqhubekayo, ukuvumela ukuba ichiza lisebenze ngcono kwindawo echaphazelekayo.
3. Izinto eziluncedo kuyilo lwefom yedosi ye-HPMC iyehla
I-HPMC ayisiyiyo kuphela i-thickener kwifomyula yokulahla, kodwa kunye nomphathi oyintloko osebenzayo. Izibonelelo zayo zibonakaliswa koku:
Ukhuseleko oluphezulu: alufakwanga ngumzimba womntu, akukho tyhefu yenkqubo, ilungele ukusetyenziswa ixesha elide.
Ukuphucula amava esigulane: akukho ukucaphuka, ukhululekile ukusebenzisa, ngokukodwa izigulane ezinovakalelo ezifana neentsana kunye nabantu abadala.
Ukuhambelana okuhle: kunokuhlalisana neentlobo ngeentlobo zezithako ezisebenzayo, akukho lula ukubangela ukuthotywa kwesidima.
Kulula ukulungiselela nokugcina: Amathontsi e-HPMC anozinzo oluhle kunye nokungafihli kwiqondo lobushushu begumbi kwaye kulula ukwenza ishishini.
Ixesha lokuposa: Jul-17-2025