HPMC (Hydroxypropyl Methyl Cellulose)kwayeI-HPC (i-Hydroxypropyl Cellulose)Zombini ezi zinto ziphuma kwiselulosi, zisetyenziswa kakhulu kumayeza, ukutya, ulwakhiwo kunye namashishini wokuthambisa. Nangona ezi zimbini zifana kwezinye iinkalo, zihluke ngokucacileyo kwisakhiwo sekhemikhali, izakhiwo zomzimba kunye neekhemikhali, ukunyibilika kunye neendawo zokusetyenziswa.
1. Ubume beMichiza kunye neempawu
I-HPMC yenziwe nge-methylation kunye ne-hydroxypropylation ye-cellulose yendalo, kwaye iqulethe i-methoxy (-OCH₃) kunye ne-hydroxypropoxy (-OCH₂CHOHCH₃) amaqela kwi-molecule.
I-HPC ifunyenwe nge-hydroxypropylation ye-cellulose, kwaye iqela layo eliphambili elisebenzayo yi-hydroxypropoxy (-OCH₂CHOHCH₃), ngaphandle kwe-methoxy.
Ngenxa yokuba i-HPMC iqulethe iqela le-methoxy elongezelelweyo kune-HPC, i-HPMC i-hydrophobic kancinane, ngelixa i-HPC i-hydrophilic. Ukongezelela, ubunzima be-molecular of HPMC buhlala buphezulu, ngelixa ubunzima be-molecular HPC bunokulawulwa ngokuguquguqukayo, okuchaphazela ukunyibilika kunye neempawu ze-viscosity ezimbini.
2. Ukunyibilika kwamanzi kunye neempawu zokunyibilika
I-HPMC inyibilika emanzini abandayo ukwenza isisombululo se-colloidal esicacileyo okanye esiguquguqukayo, kodwa asinyibiliki emanzini ashushu. Ngoko ke, i-HPMC idinga ukuchithwa kwangaphambili okanye ukusasazwa usebenzisa iindlela ezikhethekileyo kwezinye izicelo.
I-HPC ine-solubility efanelekileyo yamanzi kwaye inokunyibilika emanzini abandayo kunye nezinye izinyibilikisi eziphilayo, ezifana ne-ethanol, i-methanol, njl.
I-HPMC inepropati ye-thermogel. Xa iqondo lokushisa liphakama, isisombululo sinokuhlukana kwesigaba, ngelixa i-HPC ngokuqhelekileyo ingenzi i-thermogel, ngoko i-HPC inozinzo olungcono kwiindawo eziphezulu zokushisa.
3. I-Viscosity kunye neempawu ze-rheological
I-HPMC ine-viscosity ephezulu kwaye idla ngokusetyenziswa njenge-thickener, stabilizer kunye ne-agent-forming agent. Iimpawu zayo ze-rheological kwisisombululo samanzi zisondele kwi-pseudoplastic fluids.
I-HPC ine-viscosity ephantsi kwaye ifaneleke ngakumbi kwiifom ezifuna ukuguquguquka okungcono, njengamachiza omlomo kunye nezinto zokugubungela.
4. Iinkalo zesicelo
Ngenxa yomahluko kwiipropati zomzimba kunye neekhemikhali phakathi kwe-HPMC kunye ne-HPC, badlala iindima ezahlukeneyo kumashishini kunye neemveliso ezahlukeneyo:
Ishishini lamachiza
I-HPMC isetyenziswa ikakhulu njengesibophelelo, imathiriyeli ekhutshwa ngokuqhubekayo, imathiriyeli yokugquma ifilimu kwiipilisi zamayeza, nanjengecandelo leqokobhe leecapsules ezingenanto. Ipropathi yayo efanelekileyo yokwenza ifilimu kunye nokunyibilika kwamanzi kuyenza ibe yinto ekhethwayo yokulungiselela ukukhutshwa okuzinzileyo.
I-HPC isetyenziswa kakhulu njenge-disintegrant, i-binder, i-solubilizer, kunye ne-bioadhesive material for tablets, kwaye ifanelekile ekuphuculeni ukunyibilika kunye ne-bioavailability yamachiza. Ukongeza, i-HPC isetyenziswa ngokubanzi kwitekhnoloji ye-hot melt extrusion kune-HPMC.
Ishishini lokutya
I-HPMC ingasetyenziswa njenge-thickener yokutya, i-emulsifier, i-stabilizer, kunye ne-emulsifier stabilizer ye-cream engeyiyo yobisi.
I-HPC isetyenziswa kakhulu njenge-thickener yokutya, i-emulsifier, kunye nokuphucula, kwaye ifanelekile ukutya okungenaswekile kunye ne-calorie ephantsi.
Izithambiso kunye nokunyamekela komntu
I-HPMC ingasetyenziswa kwiimveliso zokhathalelo lwesikhumba kunye nezicoci njenge-emulsifier stabilizer.
I-HPC ifaneleke ngakumbi kwiimveliso zokhathalelo lweenwele, izinto zokuthambisa kunye neemveliso zokhathalelo lwamehlo ngenxa yokunyibilika kwayo kakuhle kwamanzi kunye nokuthambisa.
Izinto zokwakha
I-HPMC licandelo elibalulekileyo leengubo zokwakha, iimbumba, kunye ne-putty powders, edlala indima ekuqiniseni, ukugcinwa kwamanzi kunye nokuqinisa ukunamathela.
I-HPC ayisetyenziswanga kancinci kushishino lokwakha, kodwa ingasetyenziswa kwiingubo ezithile ezinyibilikayo zamanzi kunye nezincamathelisi.
5. Ukhuseleko lokusingqongileyo kunye nokhuseleko
Zombini i-HPMC kunye ne-HPC zithathwe kwi-cellulose yendalo kwaye zine-biodegradability elungileyo kunye nokhuseleko. I-HPMC ngokuqhelekileyo ithathwa njengento engeyona inetyhefu kwaye ayicaphukisi, ngelixa i-HPC isetyenziswa ngokubanzi ekutyeni kunye namayeza, ukuhlangabezana neemfuno zokhuseleko ze-FDA (US Food and Drug Administration) kunye neminye imigangatho yamazwe ngamazwe.
6. Iingcebiso zokukhetha
Ukuba i-viscosity ephezulu kunye neepropati zokwenza ifilimu ziyafuneka, i-HPMC ifanelekile, njenge-tablet coating, i-architectural coatings kunye nezinye izicelo.
Ukuba i-solubility engcono kunye ne-biocompatibility iyadingeka, i-HPC ifanelekile, njengamachiza omlomo, i-hot melt extrusion components, njl.
HPMCkwayeHPCzombini ezi zinto zibalulekileyo ze-cellulose derivatives, ezahlukileyo kwisakhiwo sekhemikhali, ukunyibilika, kunye neendawo zokusetyenziswa. I-HPMC ifaneleke ngakumbi kwi-viscosity ephezulu, i-gel-forming applications eshushu efana ne-tablet kunye nezixhobo zokwakha, ngelixa i-HPC ifaneleke ngakumbi kumalungiselelo omlomo, izithambiso kunye nokuphucula ukutya ngenxa yokunyibilika kakuhle kwamanzi kunye ne-viscosity ephantsi. Ngokweemfuno ezithile, ukukhetha izinto ezifanelekileyo kunokuphucula ukusebenza kunye nokuzinza kwemveliso.
Ixesha lokuposa: Mar-28-2025