IHydroxypropyl methylcellulose (HPMC)yinto ebalulekileyo ye-cellulose e-soluble derivative enoluhlu olubanzi lwezicelo, ngokukodwa kwi-pharmaceuticals, ukutya, izimonyo, ukwakhiwa kunye nezinye iindawo zoshishino. I-HPMC ngumgubo omhlophe okanye omhlophe, ongenancasa kwaye ongenavumba onyibilikayo emanzini kwaye unokwenza isisombululo esicacileyo, se-viscous. Iimpawu zayo zinokuhlaziywa kwiinkalo ezininzi ezifana nokwakhiwa kweekhemikhali, iipropati ezibonakalayo, kunye neendawo zokusetyenziswa.
1. Ukwakhiwa kweekhemikhali kunye nokulungiselela
I-HPMC yimveliso yemichiza efunyenwe yi-methylating kunye ne-hydroxypropylating cellulose yendalo. Isakhiwo sayo siquka amaqela amabini asebenzayo: enye i-methyl (-OCH₃) kunye nenye i-hydroxypropyl (-OCH₂CHOHCH₃). Ukuqaliswa kwala maqela mabini kwenza i-HPMC i-soluble yamanzi, i-surface esebenzayo, kwaye ine-solubility eyahlukileyo, i-viscosity kunye nezinye iimpawu.
I-cellulose-based skeleton isagcinwe kwi-molecular structure ye-HPMC, eyeye-polysaccharides yendalo kwaye inokuhambelana kakuhle kwe-biocompatibility kunye ne-biodegradability. Ngenxa yokuba i-molecule iqulethe amaqela ahlukeneyo asebenzayo, ukunyibilika kwayo kwamanzi, i-viscosity kunye nokuzinza kunokulawulwa ngokwemiqathango yokusabela.
2. Ukunyibilika kunye ne-viscosity
Uphawu oluphawulekayo lwe-HPMC kukunyibilika kwayo kakuhle kwamanzi. I-HPMC enobunzima obuhlukeneyo beemolekyuli kunye needigri ezahlukeneyo zokutshintshwa zine-solubility eyahlukeneyo kunye ne-viscosity. I-HPMC inokunyibilika ngokukhawuleza emanzini abandayo ukwenza isisombululo esizinzileyo se-colloidal, kwaye ayichatshazelwa kakhulu ngubushushu bamanzi kunye ne-pH yamanzi.
Ngokuxhomekeke kuhlobo kunye neqondo lababambeleyo, i-viscosity ye-HPMC inokulungiswa kuluhlu olubanzi. Ngokubanzi, isisombululo samanzi se-HPMC sine-viscosity ethile kwaye sinokusetyenziswa njengento enzima, i-adhesive kunye ne-stabilizer. I-viscosity yesisombululo sayo se-aqueous inokulawulwa ngokulungelelanisa ubunzima bayo be-molecular kunye ne-degree of substitution, kunye noluhlu oluqhelekileyo lwe-viscosity luvela kumakhulu ukuya kumawaka emizuzwana ye-millipascals (mPa s).
3. Ukuzinza kwe-thermal
I-HPMC inozinzo oluhle lwe-thermal. Phantsi kweemeko zobushushu obuphezulu, ubume bekhemikhali kunye neempawu ezibonakalayo ze-HPMC zihlala zizinzile, kwaye indawo yayo yokunyibilika iphezulu kune-200 ° C. Ngoko ke, yenza kakuhle kwezinye izicelo ezifuna iimeko zokushisa eziphezulu. Ngokukodwa kwimizi-mveliso yokutya kunye namayeza, i-HPMC inokumelana neemeko ezirhabaxa zokusingqongileyo xa isetyenziswa njengento ejiyileyo okanye elawulwayo yokukhululwa.
4. Amandla omatshini kunye ne-gelation
Isisombululo se-HPMC sinamandla omatshini aphezulu kunye nokunwebeka, kwaye sinokwenza i-gel isakhiwo phantsi kweemeko ezithile. Kwezinye izicelo zamashishini, i-HPMC isoloko isetyenziselwa ukwenza iijeli okanye iifilimu ezizinzileyo, ngakumbi kwiinkalo zamachiza, ukupakishwa kokutya, izithambiso, njl., ukulawula ukukhutshwa kweziyobisi, ukuqina, ukuzinzisa kunye nokufakwa kwe-encapsulation yamacandelo.
5. I-Biocompatibility kunye ne-biodegradability
Ekubeni i-HPMC ithathwe kwi-cellulose yendalo, ine-biocompatibility elungileyo, phantse akukho biotoxicity, kwaye inokutshatyalaliswa ngokukhawuleza emzimbeni. Olu phawu lwenza ukuba kube yinto esetyenziswa ngokuqhelekileyo kwishishini lamachiza, ngakumbi kumachiza omlomo kunye namalungiselelo okukhululwa alawulwayo, anokuphucula i-bioavailability yamachiza ngokulawula izinga lokukhululwa kweziyobisi.
6. Umsebenzi womphezulu
I-HPMC inomsebenzi othile womphezulu, onokunciphisa ukuxinana komphezulu wesisombululo kunye nokwandisa ukusabalalisa kunye nokumanzisa kolwelo. Yile mpawu eyenza i-HPMC isetyenziswe ngokubanzi kwizinto zokuthambisa kunye neemveliso zokhathalelo lomntu, ezinje ngee-thickeners, emulsifiers kunye nezizinzi kwiloshini, iikhrimu, ishampu kunye nezinye iimveliso.
7. Iimpawu ze-non-ionic
Ngokungafaniyo nezinye izinto zendalo zepolysaccharide, i-HPMC ayiyo-ionic. Ayinakusabela nge-ion kwisisombululo kwaye ngoko ayichaphazeli utshintsho kwi-electrolyte concentration. Olu phawu lwenza i-HPMC ibe luncedo kakhulu kwezinye izicelo ezikhethekileyo zamashishini, ngakumbi xa izisombululo ezinamanzi okanye iicolloids kufuneka zizinzile ixesha elide, i-HPMC inokuqinisekisa uzinzo kunye nokuhambelana.
8. Uluhlu olubanzi lwezicelo
Ezi mpawu ze-HPMC zenza ukuba isetyenziswe ngokubanzi kwiinkalo ezininzi, ingakumbi ezibandakanya le miba ilandelayo:
Imboni yamachiza: I-HPMC isoloko isetyenziswa njengegobolondo le-capsule yamachiza, i-carrier ye-release-release drug, i-adhesive, i-thickener, njl. Kumalungiselelo amayeza, i-HPMC inokulawula ngokufanelekileyo izinga lokukhululwa kwamachiza kunye nokuphucula i-bioavailability yamachiza.
Ishishini lokutya: I-HPMC isetyenziswa kakhulu kwiziselo, iijeli, ii-ice creams, iisosi kunye nokunye ukutya njenge-thickener, stabilizer, emulsifier kunye ne-gelling agent kwishishini lokutya, elinokuphucula incasa kunye nokuthungwa kwemveliso.
Izithambiso kunye neemveliso zokhathalelo lomntu: Kwintsimi yezithambiso, i-HPMC isetyenziswa kwiikhrimu, iimaski zobuso, iishampu, iimveliso zokhathalelo lwesikhumba kunye nezinye iimveliso ukudlala indima yokuqina, ukuzinzisa, ukumiliselwa kunye neminye imisebenzi.
Umzi-mveliso wokwakha: I-HPMC isoloko isetyenziswa njengesixhobo sokutyebisa kunye nokugcina amanzi kwizinto zokwakha. Izicelo eziqhelekileyo ziquka udaka lwesamente, i-tile adhesives, njl., Ezinokuphucula ukusebenza kokwakhiwa kunye nokuzinza kwezinto.
EzoLimo: I-HPMC ingasetyenziswa njenge-stabilizer kunye ne-thickener kwimixube ye-pesticide ukunceda ichiza lisasaze ngokulinganayo emhlabeni kunye nokuphucula umphumo wokusetyenziswa.
9. Ukhuseleko lokusingqongileyo kunye nozinzo
Ekubeni icandelo eliphambili leHPMCivela kwi-cellulose yendalo kwaye inokonakala okuhle kwe-biodegradability, ikwaneenzuzo ezithile kukhuseleko lokusingqongileyo. Njengepolima yendalo ezinzileyo, ukuveliswa kunye nokusetyenziswa kwe-HPMC akusayi kubangela umthwalo ogqithisileyo kokusingqongileyo.
I-Hydroxypropyl methylcellulose (HPMC) ineempawu ezininzi ezibalaseleyo, ezifana nokunyibilika kakuhle kwamanzi, ukulawulwa kwe-viscosity, ukuzinza kwe-thermal, i-biocompatibility, njl. Isetyenziswa ngokubanzi kumashishini amaninzi afana namayeza, ukutya, izithambiso, kunye nokwakhiwa. Ngeempawu zayo ezingezizo i-ionic, iipropathi ezihlengahlengiswayo zomzimba kunye neekhemikhali, kunye nobuhlobo bokusingqongileyo, i-HPMC ithathwa njengeyona nto ithembisayo kakhulu yepolymer. Kuphuhliso lweshishini lwexesha elizayo kunye nobuchwepheshe, i-HPMC isenophando olubanzi kunye namandla okusebenzisa.
Ixesha lokuposa: Dec-13-2024