IHydroxypropyl Methylcellulose (HPMC): IsiKhokelo esiBanzi

Intshayelelo

IHydroxypropyl methylcellulose (HPMC) i-polymer ye-semisynthetic evela kwi-cellulose, inxalenye yendalo yeendonga zeeseli zezityalo. Ngokuguqulwa kweekhemikhali, i-HPMC izuza iipropati ezizodwa, iyenza ibaluleke kakhulu kumayeza, ulwakhiwo, ukutya, kunye nezithambiso. Esi sikhokelo siphonononga ukubunjwa kwayo, izicelo, iinzuzo, kunye neendlela ezizayo.

Ukubunjwa kwemichiza kunye noLwakhiwo

HPMCyenziwe ngokuphatha i-cellulose nge-alkali, ilandelwa yi-etherification isebenzisa i-methyl chloride kunye ne-propylene oxide. Le nkqubo ithatha indawo yamaqela e-hydroxyl nge-methyl (-OCH₃) kunye ne-hydroxypropyl (-OCH₂CH (OH)CH₃) amaqela.

• Isidanga soTshintsho (DS):Ilinganisa amaqela e-methyl ngeyunithi ye-glucose (ngokuqhelekileyo i-1.0-2.2).
• Ukutshintshwa kweMolar (MS):Ibonisa amaqela e-hydroxypropyl kwiyunithi nganye (ngokuqhelekileyo i-0.1-1.0).
  Olu tshintsho lulawula ukunyibilika, i-thermal gelation, kunye ne-viscosity.

IiPropati zoMzimba kunye nezeMichiza

Iipropati Zomzimba

• Imbonakalo:Umgubo omhlophe ukuya kumhlophe.
• Ukunyibilika:Inyibilika emanzini abandayo, ayinyibiliki emanzini ashushu kunye nezinyibilikisi eziphilayo.
• I-Thermal Gelation:Yenza iijeli xa ufudumeza (ubushushu be-gelation: 50-90 ° C).
• Viscosity:Uluhlu ukusuka kwi-5 mPa·s (phantsi) ukuya kwi-200,000 mPa·s (phezulu), kuxhomekeke kubunzima bemolekyuli.

Iipropati zeMichiza

• Uzinzo lwe-pH:Izinzile kwi-pH 3-11.
• Ukonakala kwezinto eziphilayo:Indawo intle.
• Ukungalali:Ukungasetyenziswa kwizinto ezininzi.

Usetyenziso lwe-HPMC

Amachiza

• Isibophelelo seCwecwe:Ukuphucula ukuhambelana kwiipilisi (umzekelo, iMetformin).
• Ukukhutshwa okuLawulwayo:Yenza imatriki yokukhutshwa kweziyobisi okwandisiweyo (umz., Theophylline).
• Izisombululo ze-Ophthalmic:Lubricates amathontsi iliso (umz., iinyembezi ezifakelwayo).
• Ukugqunywa kwefilimu:Ibonelela ukuxhathisa ukufuma kunye nombala.

Ukwakhiwa

• Udaka/iPlaster:Ukuphucula ukusebenza kunye nokugcinwa kwamanzi.
• Izinto zokuncamathelisa iithayile:Ukwandisa ukunamathela kunye nexesha elivulekileyo.
• IiNguqulelo zesamente:Yehlisa ukuqhekeka kwaye iphucula ukuqina.

Ishishini lokutya

• I-Thickener/Emulsifier:Isetyenziswa kwiisosi, izinto ezibhakiweyo ezingenagluten, kunye nezinye iindlela zobisi.
• Izinzisi:Ikhusela ukwakheka kwekristale yomkhenkce kwiidessert ezikhenkcezileyo.

Izithambiso

• Iikhremu/IiShampoo:Isebenza njenge-thickener kunye nefilimu-yangaphambili.
• uKhupho oluZinzileyo:Ifakela izithako ezisebenzayo kwi-skincare.

Okunye Ukusetyenziswa

• Iipeyinti/izaleko:Ukuphucula ukuxubha kunye nokumiswa kwe-pigment.
• Izaramics:Idibanisa amaqhekeza kwi-greenware.

Izibonelelo ze-HPMC

• Ukhuseleko:ivunywe yi-FDA; non-toxic (LD50>5,000 mg/kg).
• Ukuguquguquka:Ukunyibilika okunokulungiswa kunye ne-viscosity.
• Ukuguqulwa kweThermal:I-Gelation xa ipholile.
• Ukuhambelana:Isebenza ngeetyuwa, ii-surfactants, kunye neepolima.

Inkqubo yokuVelisa

1. Unyango lweAlkali:I-Cellulose (i-pulp yokhuni / i-cotton) efakwe kwi-NaOH.
2. Etherification:Yasabela nge-methyl chloride kunye nepropylene oxide.
3. Ukucoca:Ihlanjwe ukususa imveliso.
4. Ukomisa/Ukugaya:Yenziwe ibe ngumgubo ocolekileyo.

Ukhuseleko kunye neMpembelelo yokusiNgqongileyo

• Ukuphatha:Sebenzisa iimaski ukuphepha ukuphefumla; engacaphukisiyo eluswini.
• Ukonakala kwezinto eziphilayo:Uthoba ngokwendalo; ubuncinci bendawo engqongileyo.

Ukuthelekiswa nezinye izinto eziphuma kwiCellulose

Imizila Yekamva

• Iinguqulelo ezintsha zonyango:Iinkqubo zokuhanjiswa kweziyobisi zeNanoparticle.
• Imveliso eZinzileyo:Iindlela zekhemistri eluhlaza zokunciphisa inkunkuma.
• Ukukhula koLwakhiwo:Imfuno yezongezo ze-eco-friendly kwiimarike ezivelayo.

Ukuguquguquka kwe-HPMC kunye nokhuseleko kuyenza ilitye lembombo kumashishini amaninzi. Njengoko uphando luqhubela phambili, indima yalo kwizicelo ezizinzileyo kunye ne-high-tech iya kwanda, iqinise ukubaluleka kwayo kwihlabathi.