ihydroxypropyl methylcellulose(HPMC)i-derivative cellulose derivative yamanzi esetyenziswa ngokubanzi kumalungiselelo amayeza, ngokukodwa kumalungiselelo aqinileyo omlomo, amalungiselelo olwelo lomlomo kunye namalungiselelo ophthalmic. Njengomxhasi obalulekileyo wamachiza, i-KimaCell®HPMC inemisebenzi emininzi, efana ne-adhesive, thickener, i-ejenti yokulawula ukukhululwa okuqhubekayo, i-gelling agent, njl. Kumalungiselelo amayeza, i-HPMC ayikwazi nje ukuphucula iimpawu zomzimba zamachiza, kodwa iphinde ikhulise ukusebenza kweziyobisi, ngoko ithatha indawo ebalulekileyo ekuphuhlisweni kwamalungiselelo.
Iipropati ze-HPMC
I-HPMC yi-ether e-soluble yamanzi okanye i-solvent-soluble cellulose ether efunyenwe ngokutshintshela inxalenye yamaqela e-hydroxyl kwii-molecule ze-cellulose kunye namaqela e-methyl kunye ne-hydroxypropyl. Ino-solubility efanelekileyo kunye ne-viscosity emanzini, kwaye isisombululo siselubala okanye sincinci. I-HPMC inozinzo oluhle kwizinto ezifana ne-pH yokusingqongileyo kunye nokutshintsha kobushushu, ngoko isetyenziswa ngokubanzi ekulungiseleleni ichiza.
I-HPMC ine-biodegradability elungileyo kwi-traintestinal tract, i-biocompatibility elungileyo kunye ne-non-toxicity, kunye namalungiselelo ayo alula ukuba abangele ukusabela kwe-aleji, nto leyo eyenza kube lula ukuyisebenzisa kumalungiselelo amayeza.
Usetyenziso oluphambili lwe-HPMC kumalungiselelo amayeza
Ukusetyenziswa kumalungiselelo okukhululwa okuzinzileyo
I-HPMC isetyenziswa ngokubanzi kumalungiselelo okukhululwa okuzinzileyo, ngakumbi kumalungiselelo omlomo aqinileyo. I-HPMC inokulawula izinga lokukhululwa kwamachiza ngesakhiwo senethiwekhi yejeli eyenzayo. Kumachiza anyibilikayo emanzini, i-HPMC njenge-ejenti yokukhutshwa ngokuzinzileyo inokulibazisa izinga lokukhululwa kwamachiza, ngaloo ndlela yandise ixesha lokusebenza kweziyobisi, ukunciphisa inani lamaxesha okudosa, kunye nokuphucula ukuthotyelwa kwesigulane.
Umgaqo wokusetyenziswa kwe-HPMC kumalungiselelo okukhululwa okuqhubekayo kusekelwe kwi-solubility yayo kunye neempawu zokudumba emanzini. Xa iipilisi okanye ii-capsules zingena kwi-gastrointestinal tract, i-HPMC idibana namanzi, ifunxa amanzi kunye nokudumba ukwenza i-gel layer, enokuthi icothise ukuchithwa kunye nokukhululwa kweziyobisi. Izinga lokukhululwa kwamachiza lingahlengahlengiswa ngokohlobo lwe-HPMC (njengamadigri ahlukeneyo okutshintshwa kwe-hydroxypropyl kunye namaqela e-methyl) kunye nokugxila kwayo.
Izibophelelo kunye neearhente zokwenza ifilim
Kumalungiselelo aqinileyo afana namacwecwe, ii-capsules, kunye ne-granules, i-HPMC njenge-binder inokuphucula ubunzima kunye nokunyaniseka kwamalungiselelo. Isiphumo bonding of HPMC ekulungiseleleni ayikwazi kuphela ukwenza amasuntswana ichiza okanye powders bond omnye komnye, kodwa ukwandisa uzinzo ukulungiswa kunye nokunyibilika kwayo emzimbeni.
Njengearhente yokwenza ifilim, i-HPMC inokwenza ifilim efanayo kwaye ihlala isetyenziselwa ukugquma iziyobisi. Ngethuba lenkqubo yokugubungela ukulungiselela, ifilimu ye-KimaCell®HPMC ayikwazi ukukhusela kuphela iyeza kwimpembelelo yendawo yangaphandle, kodwa ilawula izinga lokukhululwa kweyeza. Ngokomzekelo, ekulungiseleleni iipilisi ezifakwe kwi-enteric, i-HPMC njengento yokugquma inokuthintela ukuba iyeza likhutshwe esiswini kwaye liqinisekise ukuba ichiza likhutshwa emathunjini.
I-agent ye-gelling kunye ne-thickener
I-HPMC isetyenziswa ngokubanzi kumalungiselelo e-ophthalmic kunye namanye amalungiselelo olwelo njenge-ejenti ye-gelling. Kwiziyobisi zamehlo, i-HPMC ingasetyenziselwa njengenxalenye ye-gelling kwiinyembezi ezenziweyo ukuphucula ixesha lokugcinwa kweyeza kunye nefuthe lokuthambisa iliso, kunye nokunciphisa izinga lokunyuka kwamaconsi esweni. Ukongeza, i-HPMC nayo ineempawu ezityebileyo ezinamandla, ezinokunyusa i-viscosity yamalungiselelo kwindawo ethile yoxinaniso, kwaye ilungele ukujiya kwamalungiselelo olwelo ahlukeneyo.
Kumalungiselelo olwelo lomlomo, i-HPMC njenge-thickener inokuphucula ukuzinza kwamalungiselelo, ukukhusela imvula kunye ne-stratification yamasuntswana, kunye nokuphucula incasa kunye nokubonakala.
I-Stabilizer yamalungiselelo olwelo lomlomo
I-HPMC inokwenza isisombululo esizinzileyo se-colloidal kumalungiselelo olwelo, ngaloo ndlela iphucula ukuzinza kwamalungiselelo. Inokuphucula ukunyibilika kunye nokufana kwamachiza kumalungiselelo olwelo kunye nokuthintela icrystallization yeziyobisi kunye nemvula. Xa ulungiselela amachiza abola lula kwaye wonakala, ukongezwa kwe-HPMC kunokwandisa ngokufanelekileyo ixesha leshelufu lamachiza.
Njenge-emulsifier
I-HPMC ingasetyenziswa njenge-emulsifier ukuzinzisa i-emulsion kwaye isasaze ichiza xa ulungiselela iziyobisi zohlobo lwe-emulsion. Ngokulawula ubunzima bemolekyuli kunye noxinaniso lwe-HPMC, ukuzinza kunye neempawu ze-rheological ze-emulsion zinokutshintshwa ukuze zilungele iindlela ezahlukeneyo zamalungiselelo eziyobisi.
Uncedo lwesicelo se-HPMC
I-biocompatibility ephezulu kunye nokhuseleko: I-HPMC, njenge-derivative cellulose derivative, ine-biocompatibility efanelekileyo, ayinayo ityhefu kwaye ayicaphuki, kwaye ngoko ifaneleke kakhulu ukusetyenziswa kumalungiselelo eziyobisi.
Umsebenzi wokulawula ukukhutshwa: I-HPMC inokulawula izinga lokukhululwa kweziyobisi ngokusebenzisa iipropati zayo ze-gelling, ukwandisa ixesha lokusebenza kwamachiza, ukunciphisa ukuphindaphinda kolawulo, kunye nokuphucula ukuthotyelwa kwesigulane.
Uluhlu olubanzi lwezicelo:HPMCinokusetyenziswa kwiifom ezahlukeneyo zedosi ezifana neepilisi, iipilisi, iigranules, kunye namalungiselelo olwelo, ukuhlangabezana neemfuno zamalungiselelo ahlukeneyo amachiza.
I-Hydroxypropyl methylcellulose inexabiso elibalulekileyo lesicelo kumalungiselelo amachiza. Ayinakusetyenziswa kuphela njenge-agent-release-release, i-adhesive, kunye ne-agent-forming agent, kodwa kunye ne-thickener kunye ne-stabilizer kumalungiselelo olwelo. Iimpawu zayo ezibalaseleyo zomzimba kunye neekhemikhali zenza ukuba ibe yenye yezinto eziyimfuneko kwishishini loxubo mayeza, ngakumbi ebonisa amandla amakhulu ekuphuculeni uzinzo lwamachiza kunye nokulawula izinga lokukhutshwa kwechiza. Ngokuqhubela phambili okuqhubekayo kobuchwepheshe boxubo mayeza, amathuba okusetyenziswa kwe-KimaCell®HPMC aya kuqhubeka esanda, enikezela ngenkxaso kumalungiselelo amachiza akhuselekileyo nasebenza ngakumbi.
Ixesha lokuposa: Jan-27-2025