Ukusetyenziswa kwe-ethyl cellulose kumalungiselelo amayeza

I-Ethylcellulose (EC)yi-semi-synthetic polymer compound efunyenwe nge-ethylation ye-cellulose yezityalo zendalo. Isakhiwo esiqhelekileyo se-molecular siqulunqwe ngeeyunithi ze-glucose ezixhunywe ngamabhondi e-β-1,4-glycosidic. Ngenxa ye-biocompatibility yayo egqwesileyo, i-non-toxicity, i-controllability efanelekileyo kunye nemithombo eninzi, i-ethyl cellulose isetyenziswa ngokubanzi kumalungiselelo amayeza, ngakumbi kwishishini lamachiza.

1. Iimpawu ezisisiseko ze-ethyl cellulose

I-Ethyl cellulose ine-biocompatibility ephezulu kwaye inokubakho kumzimba womntu ixesha elide ngaphandle kokuvelisa ukuphendula okuyityhefu. Ubume bayo beekhemikhali bunika i-hydrophobicity enhle, ukuzinza, ukuxhathisa kwe-asidi kunye ne-alkali kunye neempawu ezithile zokukhululwa ezilawulwayo. Ukongezelela, i-cellulose ye-ethyl ayinyibiliki emanzini, kodwa i-soluble kwi-solvents ye-organic efana ne-ethanol, i-chloroform, i-acetone, njl. Ezi zakhiwo zinika uluhlu olubanzi lwamathemba okusetyenziswa kumalungiselelo amayeza.

2. Ukusetyenziswa kwe-ethyl cellulose kumalungiselelo amayeza

Intsimi yesicelo se-ethyl cellulose ibanzi kakhulu, igubungela amalungiselelo omlomo, i-injection, amalungiselelo angaphandle kunye nezinye iinkalo ezininzi. Ezi zilandelayo zicelo ezininzi eziphambili ze-ethyl cellulose kumalungiselelo amayeza.

2.1 Amalungiselelo alawulwayo okukhutshwa kweziyobisi ezithethwa ngomlomo

Esona sicelo sixhaphakileyo se-ethyl cellulose sinjenge-ejenti yokukhululwa elawulwayo, ngakumbi kumalungiselelo okukhutshwa okulawulwayo kumachiza omlomo. Ubume be-hydrophobic kunye nokulawulwa kwe-ethyl cellulose kuyenza ibe yinto efanelekileyo yokukhutshwa kweziyobisi. Kumalungiselelo okukhutshwa kweziyobisi ngokuzinzileyo, i-ethyl cellulose inokulibazisa izinga lokukhutshwa kwechiza ngokwenza ifilimu yokugquma, ngaloo ndlela ifezekisa injongo yokwandisa isiphumo sechiza. Ngokulungelelanisa ubunzima bemolekyuli ye-ethyl cellulose, ubukhulu bomgca wokugquma kunye nohlobo lwe-solvent ekhethiweyo, izinga lokukhululwa kunye nemodi yokukhululwa kweyeza inokulawulwa.

I-Ethyl cellulose isoloko isetyenziselwa ukulungisa iipilisi zomlomo eziqinileyo ezizinzileyo. Ichiza lisongelwe kwifilimu ye-ethyl cellulose. Inkqubo yokukhutshwa kweziyobisi inokulawulwa ngokuvuvukala kunye ne-solubility yefilimu kunye nokungena kwe-solvent. Ngokweendlela ezahlukeneyo kunye neemeko zenkqubo, i-ethyl cellulose inokulawula ngokufanelekileyo ixesha lokukhululwa kweyeza, ukunciphisa inani lamaxesha okudosa, kunye nokuphucula ukuthotyelwa kwesigulane.

2.2 Ukugquma ifilimu yeziyobisi

Kumalungiselelo eziyobisi, i-ethyl cellulose ikwasetyenziswa ngokuqhelekileyo ukugquma ifilimu, ngakumbi kumalungiselelo aqinileyo omlomo afana namacwecwe, iigranules kunye neecapsules. Njengomfanekiso wokugquma ifilimu, i-ethyl cellulose ineempawu ezintle zokwenza ifilimu, i-smoothness kunye namandla omatshini, anokubonelela ngokukhuseleka kweengqungquthela zamachiza kunye nokuthintela ukuba iyeza lingabikho phantsi okanye licasule i-gastrointestinal tract kwimo ye-asidi yesisu. Ngelo xesha, ifilimu ye-ethyl cellulose inokulawula izinga lokukhululwa kweyeza, ngokukodwa ngokulungelelanisa ubukhulu befilimu kunye nokusebenzisa i-solvents ezahlukeneyo, ii-curves ezahlukeneyo zokukhululwa zinokufezekiswa.

Njengesixhobo sokugquma, i-ethyl cellulose inokuphucula incasa yechiza, inqande ubukrakra okanye ukungakhululeki, kwaye yandise ukwamkelwa kwesigulana.

2.3 Amalungiselelo e-emulsion kunye ne-micellar

Ngenxa yokunyibilika kwayo kunye nomsebenzi ongaphezulu, i-ethyl cellulose iphinda isetyenziswe ngokubanzi kwi-emulsions kunye namalungiselelo e-micellar. Ekulungiseleleni i-emulsions, i-cellulose ye-ethyl, njenge-emulsifier kunye ne-stabilizer, inokuphucula ngokufanelekileyo ukunyibilika kweyeza kunye nokwandisa ukusebenza kweyeza. Ngokukodwa kumachiza athile anyibilikayo, i-ethyl cellulose inokunceda ukusasaza ichiza ngokuzinzileyo kwinqanaba elinamanzi, ukunciphisa imvula yechiza emanzini, kunye nokuphucula ukufumaneka kwechiza.

Kumalungiselelo e-micellar, i-cellulose ye-ethyl, njenge-stabilizer, inokwenza i-micellar ezinzileyo yesakhiwo seyeza, ngaloo ndlela iphucula ukunyibilika kunye ne-bioavailability yechiza emzimbeni, ngakumbi kumachiza athile anganyibiliki kakuhle.

2.4 Amalungiselelo eziyobisi aphambili

I-KimaCell®Ethyl cellulose isetyenziswa ngokubanzi kumalungiselelo eziyobisi, ngakumbi ekulungiseleleni i-ointments, i-creams, i-gel kunye namanye amalungiselelo. Njenge-thickener, ifilimu yangaphambili kunye ne-stabilizer, i-ethyl cellulose inokuphucula ukusasazeka, ukunamathela kunye nokufana kweziyobisi ze-topical. Kumalungiselelo ama-topical afana ne-ointments kunye ne-creams, i-ethyl cellulose inokuphucula i-viscosity kunye nokuzinza kwamalungiselelo, ukuqinisekisa ukusabalalisa okufanayo kunye nokukhululwa okuqhubekayo kweyeza ngexesha lokusetyenziswa.

2.5 Inkqubo yokuthwala iziyobisi

I-cellulose ye-Ethyl ingasetyenziselwa njengomphathi weziyobisi, ngakumbi ekulungiseleleni i-nanocarriers kunye ne-microcarriers. I-Ethyl cellulose inokwenza iikhompleksi ezineemolekyuli zamachiza ukunika ulawulo olungcono lokuhanjiswa kwechiza. Kwiinkqubo ze-nanocarrier, iipropati ezingaphezulu ze-ethyl cellulose zingaphuculwa ngokuguqulwa kweekhemikhali okanye unyango lomzimba ukuze kuphuculwe ngakumbi ukulayishwa kweziyobisi kunye nokusebenza kokulawula izinga lokukhululwa.

3. Izinto eziluncedo kunye nemingeni ye-ethyl cellulose

Njengoncedo lwamalungiselelo echiza, iKimaCell®ethyl cellulose ineengenelo ezininzi. Ine-biocompatibility efanelekileyo kunye ne-biodegradability, enokunciphisa imiphumo emibi kumzimba womntu; inokulawula ngokufanelekileyo ukukhutshwa kweziyobisi kunye nokuphucula umphumo wonyango wamachiza; Ukongeza, itekhnoloji yokucubungula i-ethyl cellulose ivuthiwe, isetyenziswa ngokubanzi, inexabiso eliphantsi, kwaye ifanelekile kwimveliso enkulu. Nangona kunjalo, i-ethyl cellulose ikwajongene nemingeni ethile. Ngokomzekelo, phantsi kweemeko ezithile ezigqithisileyo ze-pH okanye iimeko eziphezulu zokushisa, ukuzinza kwe-ethyl cellulose kunokuncipha, okunokuthi kuchaphazele umphumo wesicelo sayo kwiindawo ezithile.

Ethyl celluloseinoluhlu olubanzi lwezicelo zokusetyenziswa kumalungiselelo amayeza, ngokukodwa kwiinkalo zamalungiselelo okukhutshwa okulawulwayo, iingubo zefilimu, i-emulsions, kunye namalungiselelo omxholo. Iimpawu zayo ezibalaseleyo zomzimba kunye neekhemikhali ziyenza ibe ngumncedi oyimfuneko kumalungiselelo amayeza. Nangona kunjalo, kwizicelo ezisebenzayo, kusekho imfuneko yokwandisa kunye nokuphucula iintlobo zamachiza athile kunye neefom zokulungiselela ukunqoba imingeni yayo ekuzinzeni, ukulawula ukukhululwa, njl., kunye nokuphucula ngakumbi umphumo wonyango wamachiza kunye nokuthotyelwa kwesigulane.