HPMC (Hydroxypropyl Methyl Cellulose)leHPC (Hydroxypropyl Cellulose)ka bobeli ke lintho tse tsoang ho cellulose, tse sebelisoang haholo indastering ea meriana, ea lijo, ea kaho le ea litlolo. Le hoja tse peli li tšoana likarolong tse ling, ho hlakile hore li fapane ka sebōpeho sa lik'hemik'hale, thepa ea 'mele le ea lik'hemik'hale, ho qhibiliha le libaka tsa ts'ebeliso.
1. Sebopeho sa lik'hemik'hale le thepa
HPMC e entsoe ka methylation le hydroxypropylation ea cellulose ea tlhaho, 'me e na le lihlopha tsa methoxy (-OCH₃) le hydroxypropoxy (-OCH₂CHOHCH₃) ka molek'hule.
HPC e fumanoa ka hydroxypropylation ea cellulose, 'me sehlopha sa eona se ka sehloohong se sebetsang ke hydroxypropoxy (-OCH₂CHOHCH₃), ntle le methoxy.
Hobane HPMC e na le sehlopha sa tlatsetso sa methoxy ho feta HPC, HPMC e na le hydrophobic hanyane, athe HPC e na le hydrophilic ho feta. Ho phaella moo, boima ba limolek'hule tsa HPMC hangata bo phahame, ha boima ba limolek'hule ba HPC bo ka laoloa habonolo, bo amang ho qhibiliha le litšoaneleho tsa viscosity tsa tse peli.
2. Litšobotsi tsa ho qhibiliha ha metsi le ho qhibiliha ha metsi
HPMC e qhibiliha ka metsing a batang ho etsa tharollo ea colloidal e bonaletsang kapa e feto-fetohang, empa ha e qhibilihe metsing a chesang. Ka hona, HPMC e hloka ho qhaloa pele kapa ho qhaloa ho sebelisoa mekhoa e khethehileng lits'ebetsong tse ling.
HPC e na le ho qhibiliha ha metsi hantle 'me e ka qhibiliha ka metsing a batang le lihlahisoa tse ling tsa tlhaho, tse kang ethanol, methanol, joalo-joalo,' me e na le thepa e ntle ea ho tiisa le ho etsa lifilimi.
HPMC e na le thepa ea thermogel. Ha mocheso o phahama, tharollo e ka 'na ea arohana, ha HPC hangata e sa thehe thermogel, kahoo HPC e na le botsitso bo betere libakeng tse phahameng tsa mocheso.
3. Viscosity le thepa ea rheological
HPMC e na le viscosity e phahameng 'me hangata e sebelisoa e le ntho e teteaneng, e tsitsitseng le e etsang lifilimi. Thepa ea eona ea rheological ka tharollo ea metsi e haufi le maro a pseudoplastic.
HPC e na le viscosity e tlase 'me e loketse haholoanyane bakeng sa metsoako e hlokang metsi a betere, joalo ka lithethefatsi tsa molomo le lisebelisoa tsa ho roala.
4. Libaka tsa kopo
Ka lebaka la phapang ea thepa ea 'mele le ea lik'hemik'hale lipakeng tsa HPMC le HPC, li bapala likarolo tse fapaneng liindastering le lihlahisoa tse fapaneng:
Indasteri ea meriana
HPMC e sebelisoa haholo-holo e le setlamo, thepa e sa khaotseng, e koahelang filimi bakeng sa matlapa a meriana, hape e le karolo ea khetla ea li-capsules tse se nang letho. Thepa ea eona e ntle ea ho etsa lifilimi le ho qhibiliha ha metsi ho etsa hore e be sebaka se ratoang bakeng sa litokisetso tsa tokollo e tsoelang pele.
HPC e sebelisoa haholo-holo e le disintegrant, binder, solubilizer, le bioadhesive material for tablets, 'me e loketse ho ntlafatsa ho qhibiliha le bioavailability ea lithethefatsi. Ho feta moo, HPC e sebelisoa haholo ho theknoloji ea hot melt extrusion ho feta HPMC.
Indasteri ea lijo
HPMC e ka sebelisoa e le motenya oa lijo, emulsifier, stabilizer, le emulsifier stabilizer bakeng sa tranelate e seng ea lebese.
HPC e sebelisoa haholo-holo e le sekontiri sa lijo, emulsifier, le ntlafatso, 'me e loketse lijo tse se nang tsoekere le tse tlaase.
Litlolo le tlhokomelo ea botho
HPMC e ka sebelisoa lihlahisoa tsa tlhokomelo ea letlalo le lisebelisoa tse hloekisang joalo ka emulsifier stabilizer.
HPC e loketse ho feta bakeng sa lihlahisoa tsa tlhokomelo ea moriri, li-moisturizer le lihlahisoa tsa tlhokomelo ea mahlo ka lebaka la ho qhibiliha ha eona ha metsi le mafura.
Lisebelisoa tsa ho haha
HPMC ke karolo ea bohlokoa ea lirafshoa tsa meralo, lirekere le li-putty powders, tse bapalang karolo ho tiiseng, ho boloka metsi le ho matlafatsa ho khomarela.
HPC ha e sebelisoe hanyenyane indastering ea kaho, empa e ka sebelisoa ho lira tse khethehileng tse qhibilihang ka metsi le likhomaretsi.
5. Tšireletso le polokeho ea tikoloho
Ka bobeli HPMC le HPC li nkiloe ho selulose ea tlhaho 'me li na le biodegradability e ntle le polokeho. Ka kakaretso HPMC e nkoa e se chefo ebile ha e tenehe, ha HPC e boetse e sebelisoa haholo lijong le meriana, e finyella litlhoko tsa tšireletso tsa FDA (US Food and Drug Administration) le litekanyetso tse ling tsa machaba.
6. Litlhahiso tsa khetho
Haeba ho hlokahala thepa e phahameng ea viscosity le ea ho etsa filimi, HPMC e loketse, joalo ka ho roala letlapa, liphahlo tsa meralo le lits'ebetso tse ling.
Haeba ho hlokahala hore ho be le solubility e ntle le biocompatibility, HPC e loketse, joalo ka lithethefatsi tsa molomo, likarolo tse chesang tse chesang tsa extrusion, joalo-joalo.
HPMCleHPCka bobeli ke lintho tse tsoang ho cellulose tsa bohlokoa, tse fapaneng ka sebopeho sa lik'hemik'hale, ho qhibiliha le libaka tsa ts'ebeliso. HPMC e loketse haholo bakeng sa viscosity e phahameng, li-gel tse chesang tse entsoeng ka li-gel tse kang ho roala letlapa le thepa ea mohaho, ha HPC e loketse haholoanyane litokisetso tsa molomo, litlolo le lintlafatso tsa lijo ka lebaka la ho qhibiliha ha eona ha metsi hantle le viscosity e tlaase. Ho ea ka litlhoko tse khethehileng, ho khetha thepa e nepahetseng ho ka ntlafatsa ts'ebetso le botsitso ba sehlahisoa.
Nako ea poso: Mar-28-2025