hydroxypropyl methylcellulose(HPMC)ke motsoako oa selulose o qhibilihang ka metsing o sebelisoang haholo litokisetsong tsa meriana, haholo-holo litokisetsong tse tiileng tsa molomo, litokisetso tsa mokelikeli oa molomo le litokisetso tsa ophthalmic. Joaloka motsoako oa bohlokoa oa meriana, KimaCell®HPMC e na le mesebetsi e mengata, e kang sekhomaretsi, thickener, moemeli oa taolo ea nako e telele, gelling agent, joalo-joalo Litokisetsong tsa meriana, HPMC e ke ke ea ntlafatsa feela thepa ea 'mele ea lithethefatsi, empa hape e ntlafatsa katleho ea lithethefatsi, kahoo e nka boemo ba bohlokoa ho nts'etsopele ea litokisetso.
Thepa ea HPMC
HPMC ke ether e qhibilihang ka metsing kapa e qhibilihang ka har'a selulose e fumanoang ka ho nkela karolo ea lihlopha tsa hydroxyl limolek'huleng tsa cellulose ka lihlopha tsa methyl le hydroxypropyl. E na le solubility e ntle le viscosity ka metsing, 'me tharollo e hlakile kapa e na le turbid hanyenyane. HPMC e na le botsitso bo botle ho lintlha tse kang pH ea tikoloho le liphetoho tsa mocheso, kahoo e sebelisoa haholo ho lokisetsa lithethefatsi.
HPMC na le molemo biodegradability pampitšana gastrointestinal, molemo biocompatibility le bao e seng chefo, 'me litokisetso tsa eona ha ho bonolo ho etsa hore allergic reactions, e leng se etsang hore ho bolokehe ho sebelisoa litokisetsong tsa meriana.
Lisebelisoa tse ka sehloohong tsa HPMC litokisetsong tsa meriana
Kopo ka litokisetso tsa tokollo e tsitsitseng
HPMC e sebelisoa haholo litokisetsong tsa tokollo e tsitsitseng, haholo-holo litokisetsong tse tiileng tsa molomo. HPMC e ka laola sekhahla sa ho lokolloa ha lithethefatsi ka sebopeho sa marang-rang sa gel seo e se etsang. Lithethefatsing tse qhibilihang ka metsing, HPMC e le moemeli oa ho lokolloa ka mokhoa o tsitsitseng e ka liehisa sekhahla sa ho lokolloa ha lithethefatsi, kahoo ea lelefatsa nako ea katleho ea lithethefatsi, ea fokotsa palo ea linako tsa dosing, le ho ntlafatsa ho latela melao ea mokuli.
Molao-motheo oa ts'ebeliso ea HPMC litokisetsong tsa tokollo e tsitsitseng o ipapisitse le ho qhibiliha ha eona le thepa ea ho ruruha metsing. Ha matlapa kapa li-capsules li kena ka mpeng ea mala, HPMC e kopana le metsi, e monya metsi le ho ruruha ho etsa lesela la gel, le ka fokotsang ho qhibiliha le ho lokolloa ha lithethefatsi. Sekhahla sa tokollo ea lithethefatsi se ka fetoloa ho latela mofuta oa HPMC (joalo ka likhato tse fapaneng tsa substitution ea hydroxypropyl le lihlopha tsa methyl) le mahloriso a eona.
Li-binders le li-agents tsa ho etsa lifilimi
Litokisetsong tse tiileng tse kang matlapa, li-capsules le li-granules, HPMC e le binder e ka ntlafatsa ho thatafala le botšepehi ba litokisetso. Phello ea bonding ea HPMC ha ho lokisoa e ke ke ea etsa feela hore metsoako ea lithethefatsi kapa phofo e tlamahane, empa hape e eketsa botsitso ba ho itokisa le ho qhibiliha ha eona 'meleng.
Joaloka moemeli oa ho etsa lifilimi, HPMC e ka etsa filimi e ts'oanang 'me hangata e sebelisetsoa ho roala lithethefatsi. Nakong ea ho roala ha ho lokisoa, filimi ea KimaCell®HPMC e ke ke ea sireletsa lithethefatsi ho tsoa tšusumetsong ea tikoloho e ka ntle, empa hape e laola tekanyo ea ho lokolloa ha lithethefatsi. Ka mohlala, ha ho lokisoa matlapa a koahetsoeng ke enteric, HPMC e le thepa ea ho roala e ka thibela lithethefatsi hore li se ke tsa lokolloa ka mpeng le ho netefatsa hore moriana o lokolloa ka maleng.
Gelling agent le thickener
HPMC e sebelisoa haholo litokisetsong tsa mahlo le litokisetso tse ling tsa mokelikeli e le moemeli oa gelling. Lithethefatsing tsa mahlo, HPMC e ka sebelisoa e le karolo ea gelling ka meokho ea maiketsetso ho ntlafatsa nako ea ho boloka moriana le phello ea lubrication ea leihlo, le ho fokotsa sekhahla sa ho tsoa ha marotholi a mahlo. Ho phaella moo, HPMC e boetse e na le thepa e matla ea ho tiisa, e ka eketsang viscosity ea ho itokisa sebakeng se itseng, 'me e loketse ho tiisa litokisetso tse sa tšoaneng tsa metsi.
Litokisetsong tsa mokelikeli oa molomo, HPMC e le motenya e ka ntlafatsa botsitso ba ho itokisa, ho thibela pula le stratification ea likaroloana, le ho ntlafatsa tatso le ponahalo.
Stabilizer bakeng sa litokisetso tsa mokelikeli oa molomo
HPMC e ka theha tharollo e tsitsitseng ea colloidal ka litokisetso tsa metsi, kahoo e matlafatsa botsitso ba ho itokisa. E ka ntlafatsa solubility le ho tšoana ha lithethefatsi litokisetsong tsa mokelikeli le ho thibela crystallization ea lithethefatsi le pula. Ha ho lokisoa lithethefatsi tse bolang habonolo le tse senyehang habonolo, ho eketsoa ha HPMC ho ka lelefatsa bophelo ba sethala sa lithethefatsi.
Joalo ka emulsifier
HPMC e ka boela ea sebelisoa e le emulsifier ho tsitsisa emulsion le ho hasanya sethethefatsi ha u lokisetsa lithethefatsi tsa mofuta oa emulsion. Ka ho laola boima ba limolek'hule le mahloriso a HPMC, botsitso le thepa ea rheological ea emulsion e ka fetoloa ho etsa hore e tšoanelehe bakeng sa mefuta e fapaneng ea litokisetso tsa lithethefatsi.
Melemo ea kopo ea HPMC
Lintho tse phahameng tsa biocompatibility le polokeho: HPMC, e le motsoako oa tlhaho oa selulose, e na le biocompatibility e ntle, ha e na chefo ebile ha e halefise, kahoo e loketse haholo ho sebelisoa litokisetsong tsa lithethefatsi.
Ts'ebetso ea taolo ea tokollo: HPMC e ka laola sekhahla sa ho lokolloa ha lithethefatsi ka thepa ea eona ea gelling, ea lelefatsa ts'ebetso ea lithethefatsi, ea fokotsa khafetsa ea tsamaiso, le ho ntlafatsa ts'ebetso ea mokuli.
Mefuta e mengata ea lisebelisoa:HPMCe ka sebelisoa ka mefuta e fapaneng ea litekanyetso tse kang matlapa, li-capsules, granules, le litokisetso tsa metsi, ho finyella litlhoko tsa litokisetso tse fapaneng tsa lithethefatsi.
Hydroxypropyl methylcellulose e na le bohlokoa ba ts'ebeliso ea litokiso tsa lithethefatsi. E ke ke ea sebelisoa feela e le moemeli oa ho lokolloa ka mokhoa o tsitsitseng, sekhomaretsi, le moemeli oa ho etsa filimi, empa hape e le setsi se teteaneng le se tsitsitseng ha ho etsoa litokisetso tsa metsi. Litšobotsi tsa eona tse babatsehang tsa 'mele le lik'hemik'hale li etsa hore e be e' ngoe ea li-excipients tsa bohlokoa indastering ea meriana, haholo-holo e bontšang bokhoni bo boholo ba ho ntlafatsa botsitso ba lithethefatsi le ho laola sekhahla sa ho lokolloa ha lithethefatsi. Ka tsoelopele e tsoelang pele ea theknoloji ea meriana, litebello tsa tšebeliso ea KimaCell®HPMC li tla tsoela pele ho hola, ho fana ka tšehetso bakeng sa litokisetso tse sireletsehileng le tse sebetsang haholoanyane tsa lithethefatsi.
Nako ea poso: Jan-27-2025