Hydroxypropyl methylcellulose (HPMC)waa derivative cellulose biyo-milmi ah oo si weyn loogu isticmaalo diyaarinta daawooyinka, gaar ahaan diyaarinta adag afka, diyaarinta dareeraha afka iyo diyaarinta indhaha. Sida qalab dawo oo muhiim ah, KimaCell®HPMC waxay leedahay hawlo badan, sida xabagta, dhumucda, wakiilka xakamaynta sii-deynta joogtada ah, wakiilka gelling, iwm. Diyaargarowga dawooyinka, HPMC ma hagaajin karto oo kaliya sifooyinka jirka ee daawooyinka, laakiin sidoo kale waxay kor u qaadaysaa waxtarka daawooyinka, sidaas darteed waxay ku jirtaa boos muhiim ah horumarinta.
Guryaha HPMC
HPMC waa eter cellulose biyo-milmi leh ama dareere-milmi kara oo lagu beddelay qayb ka mid ah kooxaha hydroxyl ee molecules cellulose leh methyl iyo hydroxypropyl. Waxay leedahay milmayn wanaagsan iyo viscosity ee biyaha, xalkuna waa mid hufan ama wax yar oo qalafsan. HPMC waxay leedahay xasillooni wanaagsan xagga arrimaha sida pH deegaanka iyo isbeddelada heerkulka, sidaa darteed si weyn ayaa loogu isticmaalaa diyaarinta daroogada.
HPMC waxay leedahay biodegradability wanaagsan ee mareenka caloosha iyo mindhicirka, bioocompatibility wanaagsan iyo aan sun, iyo diyaargarowgeed ma fududa in ay sababaan falcelinta xasaasiyadda, taas oo ka dhigaysa ammaan ah in loo isticmaalo diyaarinta daawooyinka.
Codsiyada ugu muhiimsan ee HPMC ee diyaarinta daawooyinka
Codsiga diyaarinta sii-deynta joogtada ah
HPMC waxaa si weyn loogu isticmaalaa diyaarinta sii-deynta joogtada ah, gaar ahaan diyaarinta adag ee afka. HPMC waxa ay ku xakamayn kartaa heerka sii daynta dawooyinka iyada oo loo marayo qaab dhismeedka shabakadda gel ee ay samayso. Daawooyinka biyaha ku milma, HPMC oo ah wakiilka sii daynta joogtada ah waxay daahi kartaa heerka sii daynta daawooyinka, si ay u dheeraato muddada waxtarka daawada, yaraynta tirada wakhtiyada qaadashada, iyo hagaajinta u hogaansanaanta bukaanka.
Mabda'a codsiga ee HPMC ee diyaarinta sii-deynta joogtada ah waxay ku salaysan tahay milmaheeda iyo sifooyinka bararka biyaha. Marka kiniinka ama kaabsooshadu galaan mareenka caloosha iyo mindhicirka, HPMC waxay la timaadaa biyaha, waxay nuugtaa biyaha oo bararaan si ay u sameeyaan lakabka jel, kaas oo hoos u dhigi kara milanka iyo sii deynta daroogada. Heerka siideynta daawooyinka waxaa lagu hagaajin karaa iyadoo loo eegayo nooca HPMC (sida heerarka kala duwan ee beddelka kooxaha hydroxypropyl iyo methyl) iyo feejignaanteeda.
Xirayaasha iyo wakiilada filim samaynta
Diyaargarowga adag sida kiniiniyada, kaabsalka, iyo granules, HPMC sida xidhe ahaan waxay wanaajin kartaa adkaanta iyo daacadnimada diyaarinta. Saamaynta isku-xidhka ee HPMC ee diyaarinta ma aha oo kaliya ka dhigi karta qayb ka mid ah daroogada ama budada midba midka kale, laakiin sidoo kale waxay kordhisaa xasilloonida diyaarinta iyo milanka jirka.
Sida wakiilka samaynta filimada, HPMC waxay samayn kartaa filim isku mid ah waxaana badanaa loo isticmaalaa daahan daroogada. Inta lagu jiro habka daaha ee diyaarinta, filimka KimaCell®HPMC kaliya kama ilaalin karo daawada saameynta deegaanka dibadda, laakiin sidoo kale xakameynaya heerka sii deynta daawada. Tusaale ahaan, marka la diyaarinayo kiniinnada dahaarka leh ee mindhicirka, HPMC oo ah maaddada dahaarka ah waxay ka hortagi kartaa in daawada lagu sii daayo caloosha oo hubiso in daawada lagu sii daayo mindhicirka.
Wakiilka iyo dhumucda
HPMC waxaa si weyn loogu isticmaalaa diyaarinta indhaha iyo diyaarinta dareeraha kale sida wakiilka gelling. Daawooyinka indhaha, HPMC waxa loo isticmaali karaa sida qayb gelling ah oo ilmada macmal ah si loo hagaajiyo wakhtiga haynta daawada iyo saamaynta saliidayn ee isha, iyo in la yareeyo heerka uumiga ee dhibcaha indhaha. Intaa waxaa dheer, HPMC sidoo kale waxay leedahay sifooyin dhumucyo xoog leh, taas oo kordhin karta viscosity ee diyaarinta ee fiirsashada gaar ah, oo ku habboon dhumucyada diyaarinta dareere kala duwan.
Diyaarinta dareeraha afka, HPMC sida dhumucdiisu waxay wanaajin kartaa xasilloonida diyaarinta, ka hortagga roobabka iyo xayndaabyada qaybaha, waxayna wanaajisaa dhadhanka iyo muuqaalka.
Dejinta diyaarinta dareeraha afka
HPMC waxay samayn kartaa xal kolloidal ah oo deggan diyaarinta dareeraha, taas oo kor u qaadeysa xasilloonida diyaarinta. Waxay hagaajin kartaa milanka iyo isku-duubnaanta daawooyinka ee diyaarinta dareeraha waxayna ka hortagtaa crystallization daroogada iyo roobabka. Marka la diyaarinayo qaar ka mid ah dawooyinka si fudud u burbursan iyo kuwa baabi'in kara, ku darida HPMC waxay si wax ku ool ah u kordhin kartaa nolosha shelf ee daawooyinka.
Sida emulsifier
HPMC waxa kale oo loo isticmaali karaa emulsifier ahaan si loo dejiyo emulsion-ka oo loo kala diro daawada marka la diyaarinayo dawooyinka nooca emulsion-ka ah. Iyadoo la xakameynayo miisaanka molecular iyo xoojinta HPMC, xasiloonida iyo sifooyinka rheological ee emulsion waa la hagaajin karaa si ay ugu habboonaato noocyada kala duwan ee diyaarinta daroogada.
Faa'iidooyinka codsiga ee HPMC
Biocompatibility Sare iyo Badbaadada: HPMC, sida derivative cellulose dabiiciga ah, waxa uu leeyahay bioocompatibility wanaagsan, aan sun iyo aan xanaaqin, oo sidaas daraaddeed aad ugu habboon in loo isticmaalo diyaarinta daroogada.
Hawsha xakamaynta sii deynta: HPMC waxa ay xakamayn kartaa heerka sii daynta dawooyinka iyada oo loo marayo sifooyinkeeda gelling-ka, waxa ay dheeraynaysaa waxtarka dawooyinka, waxa ay yaraynaysaa inta jeer ee maamulka,waxana ay wanaajisaa u hogaansanaanta bukaanka.
Codsiyada kala duwan:HPMCwaxaa loo isticmaali karaa noocyo kala duwan oo qiyaas ah sida kiniinno, kaabsal, granules, iyo diyaargarowga dareeraha, buuxinta baahida daawooyinka kala duwan.
Hydroxypropyl methylcellulose waxay leedahay qiime codsi oo muhiim ah diyaarinta daroogada. Looma isticmaali karo oo kaliya sida wakiilka sii-daynta joogtada ah, xabagta, iyo wakiilka filim samaynta, laakiin sidoo kale sidii dhumuc iyo xasiliye ee diyaarinta dareeraha. Sifooyinkeeda jidheed iyo kiimikaad ee aadka u wanaagsan ayaa ka dhigaya mid ka mid ah waxyaabaha lagama maarmaanka u ah warshadaha dawooyinka, gaar ahaan muujinta awood weyn oo lagu hagaajinayo xasilloonida daroogada iyo xakamaynta heerka sii deynta daroogada. Horumarka joogtada ah ee tignoolajiyada dawooyinka, rajada codsiga ee KimaCell®HPMC waxay sii wadi doontaa inay balaadhiso, iyadoo siinaysa taageero ka badbaado badan oo wax ku ool ah diyaarinta daroogada.
Waqtiga boostada: Jan-27-2025