Hydroxypropyl Methylcellulose pamusanganiswa wedhaka

Hydroxypropyl methylcellulose (HPMC) chinhu chakakosha chinonyungudika nemvura polima inoshandiswa zvakanyanya mukuvaka dhaka. Kukora kwayo kwakanaka, kuchengetwa kwemvura, lubrication uye bonding zvivakwa zvinoita kuti ive chinhu chinodiwa chekuwedzera mune zvemazuva ano zvekuvaka.

1. Basic maitiro eHPMC

HPMC isiri-ionic cellulose ether. Yayo molecular chimiro ine hydroxypropyl uye methyl substituents, iyo inoita kuti ive yakanaka kunyungudika kwemvura uye basa repamusoro. Iwo makuru mabasa eHPMC anosanganisira kunyudza kwemvura uye kuzvimba, kukora, kugadzira firimu rekudzivirira, kuvandudza kunamatira uye kuwedzera plasticity. Kunyungudika kwayo kunokonzerwa nekushisa. Iyo inowanzonyungudika zvishoma nezvishoma pakudziya kwakadzika, asi inogona kunyungudika nekukurumidza uye kugadzira yakagadzikana colloidal mhinduro kana tembiricha ichikwira.

2. Mechanism yekuita kweHPMC pamusanganiswa wedhaka

Basa reHPMC mudhaka system rinonyanya kuratidzwa mune zvinotevera zvinhu:

Kuchengetedza mvura

Iwo hydroxypropyl uye methyl mapoka mune mamolecular chimiro cheHPMC anogona kuumba hydrogen zvisungo nemamorekuru emvura, zvichiita kuti ive nesimba rekunyudza mvura, nekudaro kunonoka kubuda kwemvura nekuvandudza kuchengetwa kwemvura kwedhaka. Munguva yekuvaka dhaka, kuchengetwa kwemvura kwakanaka kunogona kuderedza kurasikirwa kwemvura nguva isati yakwana mujinga kana nharaunda, kudzivirira kutsemuka kunokonzerwa nekuderera, uye kunatsiridza mashandiro ekuvaka uye kusimba kwedhaka mushure mekuoma.

Kukora mhedzisiro

HPMC ichagadzira viscous colloidal mhinduro mushure mekunyungudika mumvura. Kuwedzera kwayo kunokonzera kunogona kuvandudza rheological properties yedhaka, kuita kuti iwedzere kuwirirana uye kuchengetedza chimiro, uye kuderedza kubuda kwemvura uye kupatsanurwa. Huwandu hwakakodzera hweHPMC hunogona kuvandudza kushanda kwedhaka uye kugadzirisa mashandiro ekuvaka. Panguva imwecheteyo, dhaka rinogona kuvhara zvakaenzana chigadziko uye kuvandudza kushanda kwekubatanidza.

Lubricating effect

HPMC mhinduro inoumba firimu rakatetepa rekuzora mudhaka, richigadzira pamusoro pemasimende zvimedu uye akakwenenzverwa mudhaka akatsetseka, nekudaro kuderedza kukweshera kwemukati kwedhaka, kunatsiridza kuyerera kwekuvaka, uye kuita plaster kana kukokera kupfava. Mukuwedzera, iyo lubricating effect inogona zvakare kuderedza kupokana pakati pezvishandiso zvekuvaka nedhaka, uye kugadzirisa nyore kwekuvaka.

Kuvandudza kunamatira

HPMC inogona kuumba network dhizaini mudhaka, kuvandudza kunamatira kwedhaka, uye kugonesa dhaka kuti rinamire zvakanyanya kusimba pamusoro pechigadziko. Ichi chivakwa chakakosha pakushandisa senge mataira anonamira uye plaster dhaka, uye inogona kunyatso dzivirira iyo dhaka layer kuti isadonha nekuvandudza kusimba kwese.

Kufurira pane simende hydration

Kuchengetedza kwemvura kweHPMC kunobvumira zvimedu zvesimende kuti zvirambe zvichinyura kwenguva yakareba, kuvandudza dhigirii remvura, uye nekudaro kuvandudza simba uye kusimba kwedhaka rakaomarara. Uye zvakare, iyo firimu yakaumbwa neHPMC pamusoro pemasimende masimende inogona kukanganisa kugoverwa kwezvigadzirwa zve hydration, zvichiita kuti hydration process iwedzere yunifomu, iyo inobatsira kuvandudza kushanda kwese kwedhaka.

Hydroxypropyl methylcellulose mumisanganiswa yedhaka inonyanya kuvandudza kushanda, kubatanidza kuita uye kusimba kwedhaka nekuchengetedza mvura, kukora, kuzora, kunatsiridza kunamatira uye kukanganisa simende hydration. Kuwedzerwa kwakakodzera kweHPMC inogona kunyatso kuvandudza kushanda kwakazara kwedhaka uye kusangana nezvinodiwa zvemapurojekiti akasiyana. Nekudaro, iyo dosi yeHPMC inoda kukwidziridzwa zvinoenderana nezvinodiwa zvekuvaka kudzivirira matambudziko akadai sekushandisa zvakanyanya zvinotungamira mukudzikiswa kwekushanda kana kurebesa nguva yekumisikidza. Mune ramangwana, iyo mashandiro ekuita kweHPMC mudhaka ichiri kuda kuwedzeredzwa kuti ikwidzise mashandisiro ayo uye kusimudzira kuvandudzwa kwehunyanzvi hwekuvaka.