hydroxypropyl methylcellulose (HPMC)inonzi water-soluble cellulose derivative inoshandiswa zvakanyanya mukugadzirira kwemishonga, kunyanya mumuromo wakasimba kugadzirira, oral liquid kugadzirira uye ophthalmic kugadzirira. Semushonga unokosha wemishonga, KimaCell®HPMC ine mabasa akawanda, akadai seadhesive, thickener, inochengetedza-kusunungurwa control agent, gelling agent, etc. Mukugadzirira kwemishonga, HPMC haigoni kungovandudza zvinhu zvemuviri zvemishonga, asiwo inowedzera kushanda kwemishonga, saka inotora nzvimbo inokosha mukugadzirwa kwegadziriro.
Zvivakwa zveHPMC
HPMC inonyungudika mumvura kana yakanyungudika selulosi ether inowanikwa nekutsiva chikamu chemapoka ehydroxyl mumamorekuru ecellulose nemapoka emethyl uye hydroxypropyl. Iyo ine yakanaka solubility uye viscosity mumvura, uye mhinduro iri pachena kana zvishoma turbid. HPMC ine kugadzikana kwakanaka kune zvinhu zvakadai sezvakatipoteredza pH uye kuchinja kwekushisa, saka inoshandiswa zvakanyanya mukugadzirira zvinodhaka.
HPMC ine biodegradability yakanaka mudumbu redumbu, yakanaka biocompatibility uye isiri-chepfu, uye kugadzirira kwayo hakusi nyore kukonzera allergic reactions, izvo zvinoita kuti zvive zvakachengeteka kushandisa mumishonga yekugadzirira.
Kushandiswa kukuru kweHPMC mukugadzirira kwemishonga
Kushandiswa mukugadzirira-kusunungurwa kunoramba kuripo
HPMC inoshandiswa zvakanyanya mukugadzirisa-kuburitswa gadziriro, kunyanya mumuromo kugadzirira kwakasimba. HPMC inogona kudzora kuburitswa kwemishonga kuburikidza nejel network magadzirirwo ainoumba. Mumishonga inonyungudika mumvura, HPMC sechishandiso chinoramba chichiburitswa inogona kunonoka kuburitswa kwemishonga, nekudaro ichirebesa nguva yekushanda kwezvinodhaka, kuderedza nhamba yenguva dzedosing, nekuvandudza kutevedza kwemurwere.
Iyo misimboti yekushandisa yeHPMC mukugadzirisa-kuburitswa gadziriro yakavakirwa pakunyungudika kwayo uye kuzvimba zvivakwa mumvura. Kana mahwendefa kana capsules achipinda mudumbu, HPMC inosangana nemvura, inotora mvura uye inoputika kuita gel layer, iyo inogona kuderedza kupera uye kusunungurwa kwemishonga. Kuburitswa kwemishonga kunogona kugadziridzwa zvinoenderana nerudzi rweHPMC (senge madhigirii akasiyana ekutsiviwa kwehydroxypropyl uye methyl mapoka) uye kuiswa kwayo.
Binders uye vamiririri vekugadzira mafirimu
Mugadziriro dzakasimba dzakadai semapiritsi, capsules, uye granules, HPMC sebhainda inogona kuvandudza kuoma uye kuvimbika kwegadziriro. Iko kusungirirwa kweHPMC mukugadzirira hakungoite kuti mishonga yemishonga kana hupfu hubatane kune mumwe nemumwe, asiwo inowedzera kugadzikana kwekugadzirira uye kunyungudika kwayo mumuviri.
Semugadziri wekugadzira firimu, HPMC inogona kuumba yunifomu firimu uye inowanzo shandiswa kupfekedza zvinodhaka. Munguva yekuputira maitiro ekugadzirira, iyo KimaCell®HPMC firimu haigone chete kuchengetedza mushonga kubva kune pesvedzero yekunze kwezvakatipoteredza, asi zvakare kudzora kuburitswa kwemushonga. Semuyenzaniso, mukugadzirira mahwendefa eenteric-coated, HPMC sechinhu chekuputira inogona kudzivirira mushonga kubva pakuburitswa mudumbu uye kuona kuti mushonga unoburitswa muura.
Gelling agent uye thickener
HPMC inoshandiswa zvakanyanya mukugadzirira kwemaziso uye mamwe magadzirirwo emvura se gelling agent. Mumishonga yemaziso, HPMC inogona kushandiswa sechikamu chegelling mumisodzi yekugadzira kuvandudza nguva yekuchengeta kwemushonga uye nemafuta ekuzora kweziso, uye kuderedza chiyero chekubuda kwemadonhwe eziso. Uye zvakare, HPMC ine zvakare yakasimba thickening zvivakwa, izvo zvinogona kuwedzera viscosity yekugadzirira pane imwe concentration, uye yakakodzera kukora kwakasiyana gadziriro yemvura.
Mukugadzirira kwemvura yemuromo, HPMC seyakakora inogona kuvandudza kugadzikana kwegadziriro, kudzivirira kunaya uye stratification yezvimedu, uye kunatsiridza kuravira uye kutaridzika.
Stabilizer ye oral liquid kugadzirira
HPMC inogona kuumba yakagadzikana colloidal mhinduro mune yemvura gadziriro, nekudaro ichiwedzera kugadzikana kwegadziriro. Inogona kuvandudza kunyungudika uye kufanana kwezvinodhaka mukugadzirira kwemvura uye kudzivirira crystallization yezvinodhaka uye kunaya. Paunenge uchigadzira mimwe mishonga inoora uye inoparara zviri nyore, kuwedzerwa kweHPMC kunogona kuwedzera hupenyu hwesherufu yemishonga.
Se emulsifier
HPMC inogonawo kushandiswa se emulsifier kudzikamisa emulsion uye kuparadzira mushonga pakugadzirira emulsion-mhando mishonga. Nekudzora uremu hwemamorekuru uye kusungirirwa kweHPMC, kugadzikana uye rheological maitiro emulsion anogona kugadziridzwa kuti ive yakakodzera kune akasiyana maitiro ekugadzirira zvinodhaka.
Mabhenefiti ekushandisa kweHPMC
High biocompatibility uye kuchengeteka: HPMC, sechisikigo che cellulose derivative, ine biocompatibility yakanaka, haina chepfu uye isingatsamwisi, uye naizvozvo yakakodzera chaizvo kushandiswa mukugadzirira zvinodhaka.
Release control function: HPMC inogona kudzora kuburitswa kwezvinodhaka kuburikidza neiyo gelling zvimiro, kurebesa kushanda kwemishonga, kuderedza kuwanda kwekutonga, nekuvandudza kutevedzera kwevarwere.
Zvakawanda zvekushandisa:HPMCinogona kushandiswa mumhando dzakasiyana dzeyero senge mahwendefa, capsules, granules, uye gadziriro yemvura, kusangana nezvinodiwa zvemhando dzakasiyana dzemishonga.
Hydroxypropyl methylcellulose ine kukosha kwekushandisa kwakakosha mukugadzirira kwezvinodhaka. Iyo haigone kushandiswa chete seyakagadziriswa-kuburitswa mumiriri, inonamira, uye firimu-inogadzira agent, asiwo seyakakora uye inodzikamisa mukugadzirira kwemvura. Hunhu hwayo hwakanakisa hwemuviri nemakemikari hunoita kuti ive imwe yezvakakosha zvekushandisa muindasitiri yemishonga, kunyanya kuratidza kugona kukuru mukuvandudza kugadzikana kwezvinodhaka uye kudzora kuburitswa kwezvinodhaka. Nekuenderera mberi kuenderera mberi kwehunyanzvi hwekugadzira mishonga, tarisiro yekushandiswa kweKimaCell®HPMC icharamba ichikura, ichipa rutsigiro rwekugadzirira zvinodhaka zvakachengeteka uye zvinoshanda zvakanyanya.
Nguva yekutumira: Jan-27-2025