HPMC (Hydroxypropyl Methyl Cellulose)ndiHPC (Hydroxypropyl Cellulose)zonsezi ndi zochokera ku cellulose, zomwe zimagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, chakudya, zomangamanga ndi zodzikongoletsera. Ngakhale kuti ziwirizi n'zofanana m'mbali zina, mwachiwonekere ndizosiyana mu kapangidwe ka mankhwala, thupi ndi mankhwala katundu, solubility ndi malo ntchito.
1. Kapangidwe ka mankhwala ndi katundu
HPMC imapangidwa ndi methylation ndi hydroxypropylation ya cellulose yachilengedwe, ndipo imakhala ndi methoxy (-OCH₃) ndi magulu a hydroxypropoxy (-OCH₂CHOHCH₃) mu molekyulu.
HPC imapezeka ndi hydroxypropylation ya cellulose, ndipo gulu lake lalikulu ndi hydroxypropoxy (-OCH₂CHOHCH₃), popanda methoxy.
Chifukwa HPMC ili ndi gulu lowonjezera la methoxy kuposa HPC, HPMC imakhala ndi hydrophobic pang'ono, pomwe HPC imakhala ya hydrophilic. Kuonjezera apo, kulemera kwa maselo a HPMC nthawi zambiri kumakhala kokwera kwambiri, pamene kulemera kwa maselo a HPC kumatha kuyendetsedwa bwino, zomwe zimakhudza kusungunuka ndi maonekedwe a viscosity awiriwo.
2. Kusungunuka kwamadzi ndi makhalidwe osungunuka
HPMC imasungunuka m'madzi ozizira kuti ipange njira yowonekera kapena yowoneka bwino ya colloidal, koma imasungunuka m'madzi otentha. Chifukwa chake, HPMC iyenera kusungunuka kale kapena kubalalitsidwa pogwiritsa ntchito njira zapadera pamapulogalamu ena.
HPC imakhala ndi kusungunuka kwamadzi bwino ndipo imatha kusungunuka m'madzi ozizira ndi zosungunulira zina za organic, monga ethanol, methanol, etc., ndipo imakhala ndi kukhuthala bwino komanso kupanga mafilimu.
HPMC ili ndi katundu wa thermogel. Kutentha kukakwera, yankho likhoza kukhala losiyana, pamene HPC nthawi zambiri simapanga thermogel, kotero HPC imakhala yokhazikika m'malo otentha kwambiri.
3. Viscosity ndi rheological katundu
HPMC ili ndi mamasukidwe apamwamba ndipo nthawi zambiri imagwiritsidwa ntchito ngati thickener, stabilizer ndi filimu kupanga wothandizira. Zake rheological katundu mu amadzimadzi njira ali pafupi ndi pseudoplastic madzimadzi.
HPC ili ndi mamasukidwe ocheperako ndipo ndiyoyeneranso kupanga mapangidwe omwe amafunikira madzi abwinoko, monga mankhwala amkamwa ndi zida zokutira.
4. Minda yofunsira
Chifukwa cha kusiyana kwakuthupi ndi mankhwala pakati pa HPMC ndi HPC, amatenga maudindo osiyanasiyana m'mafakitale ndi zinthu zosiyanasiyana:
Makampani opanga mankhwala
HPMC imagwiritsidwa ntchito kwambiri ngati chomangira, chotulutsa chokhazikika, zokutira filimu pamapiritsi amankhwala, komanso ngati chipolopolo cha makapisozi opanda kanthu. Katundu wake wabwino wopangira filimu komanso kusungunuka kwamadzi kumapangitsa kuti ikhale yothandiza kwambiri pokonzekera kumasulidwa kosalekeza.
HPC imagwiritsidwa ntchito makamaka ngati disintegrant, binder, solubilizer, ndi bioadhesive material yamapiritsi, ndipo ndiyoyenera kukonza kusungunuka ndi bioavailability wa mankhwala. Komanso, HPC chimagwiritsidwa ntchito kwambiri otentha Sungunulani extrusion luso kuposa HPMC.
Makampani opanga zakudya
HPMC angagwiritsidwe ntchito monga chakudya thickener, emulsifier, stabilizer, ndi emulsifier stabilizer kwa sanali mkaka kirimu.
HPC imagwiritsidwa ntchito makamaka ngati chowonjezera chakudya, emulsifier, komanso chowongolera, ndipo ndi yoyenera pazakudya zopanda shuga komanso zochepa zama calorie.
Zodzoladzola ndi chisamaliro chaumwini
HPMC angagwiritsidwe ntchito mankhwala chisamaliro khungu ndi zotsukira monga emulsifier stabilizer.
HPC ndiyoyenera kwambiri pazinthu zosamalira tsitsi, zonyowa komanso zosamalira maso chifukwa cha kusungunuka kwake kwamadzi komanso kuthirira.
Zomangira
HPMC ndi gawo lofunikira la zokutira zomanga, matope, ndi ufa wa putty, womwe umathandizira kukulitsa, kusunga madzi komanso kumamatira.
HPC imagwiritsidwa ntchito pang'onopang'ono pantchito yomanga, koma imatha kugwiritsidwa ntchito ngati zokutira ndi zomatira zosungunuka m'madzi.
5. Kuteteza chilengedwe ndi chitetezo
Onse HPMC ndi HPC zimachokera ku mapadi achilengedwe ndipo ali ndi biodegradability wabwino ndi chitetezo. HPMC nthawi zambiri imawonedwa ngati yopanda poizoni komanso yosakwiyitsa, pomwe HPC imagwiritsidwanso ntchito kwambiri muzakudya ndi zamankhwala, kukwaniritsa zofunikira zachitetezo cha FDA (US Food and Drug Administration) ndi miyezo ina yapadziko lonse lapansi.
6. Malingaliro osankha
Ngati ma viscosity apamwamba komanso kupanga mafilimu amafunikira, HPMC ndiyoyenera, monga zokutira piritsi, zokutira zomanga ndi ntchito zina.
Ngati kusungunuka kwabwinoko ndi biocompatibility kumafunika, HPC ndiyoyenera, monga mankhwala amkamwa, zigawo zotentha zosungunuka, ndi zina.
Mtengo wa HPMCndiHPCZonsezi ndizochokera ku cellulose, zomwe zimasiyana mu kapangidwe ka mankhwala, kusungunuka, komanso madera ogwiritsira ntchito. HPMC ndi yoyenera kwambiri kukhuthala kwakukulu, kupanga gel osakaniza monga kupaka mapiritsi ndi zipangizo zomangira, pamene HPC ndiyoyenera kukonzekera pakamwa, zodzoladzola ndi zowonjezera zakudya chifukwa cha kusungunuka kwake kwamadzi komanso kutsika kwamakamaka. Malinga ndi zosowa zenizeni, kusankha zinthu zoyenera kungapangitse kuti ntchitoyo ikhale yolimba komanso yokhazikika.
Nthawi yotumiza: Mar-28-2025