Hydroxypropylcellulose (HPC) bụ ihe mgbakwunye ọgwụ a na-ejikarị na usoro nkwusioru.Nkwusioru bụ sistemu dị iche iche nwere ihe siri ike gbasasịrị n'ime ụgbọ mmiri mmiri.A na-eji usoro ọgwụ ndị a eme ihe n'ọtụtụ ebe na ọgwụ maka ibuga ọgwụ na-adịghị edozi ma ọ bụ na-akwụghị ụgwọ na ngwọta.HPC na-arụ ọtụtụ ọrụ dị mkpa na usoro nkwusioru, na-enye aka na nkwụsi ike ha, viscosity na arụmọrụ zuru oke.
1. Okwu Mmalite nke Hydroxypropylcellulose (HPC):
Hydroxypropylcellulose bụ cellulose ewepụtara site na mgbanwe kemịkalụ nke cellulose site na iwebata otu hydroxypropyl n'ime ọkpụkpụ azụ cellulose.A na-eji ya n'ọtụtụ ebe na ọgwụ dị ka ihe na-akpali akpali n'ihi njirimara ya dị mma dị ka solubility na mmiri na ihe mgbaze organic, biodegradability, ike ịmepụta ihe nkiri, yana ndakọrịta na ihe ndị ọzọ na-emepụta ọgwụ na-arụ ọrụ ọgwụ (APIs).
2. Ọrụ HPC na nhazi nkwusioru:
Na usoro nkwusioru, HPC na-arụ ọtụtụ ọrụ:
a.Nkwụsi ike nkwusioru:
Otu n'ime isi ọrụ nke HPC na nkwusioru bụ ime ka ihe siri ike gbasasịrị.Ọ na-arụzu nke a site n'ịkpụ akwa mkpuchi gburugburu ihe ndị ahụ, na-egbochi ha ịchịkọta ma ọ bụ dozie.Nkwụsi ike a dị oke mkpa maka idowe ịdị n'otu na nkwụsi ike nke nkwusioru ahụ n'oge ndụ ya niile.
b.Mgbanwe viscosity:
HPC nwere ike imetụta viscosity nke nkwusioru ahụ.Site n'ịgbanwe ntinye nke HPC na nhazi ahụ, enwere ike ịhazi viscosity iji nweta ihe ndị a chọrọ.Viscosity kwesịrị ekwesị na-eme ka nkwusioru zuru oke nke ihe siri ike na ịdị mfe nke ịwụsa na dosing.
c.Ọdịmma na ngbanwe nke ọma:
HPC na-eme ka nkwụsị nke nkwusioru dịkwuo mma, na-eme ka ọ dị mfe ịwụsa na inye ha.Na mgbakwunye, ọ na-enyere aka n'ịgbasa ụmụ irighiri ihe mgbe nkwusioru ahụ maa jijiji ma ọ bụ kpasuru ya, na-ahụ na ịdị n'otu na nkwekọ n'usoro nchịkwa.
d.Ndakọrịta na nkwụsi ike:
HPC dakọtara na ọtụtụ ngwa ahịa ọgwụ na ihe ndị ọzọ.Ọdịdị inert ya na enweghị mmeghachi omume na-eme ka ọ dị mma maka iji ya mee ihe n'ụdị dị iche iche.Ọzọkwa, HPC na-enye aka na nkwụsi ike nke nkwusioru site na igbochi nkewa nke oge, sedimentation, ma ọ bụ kristal.
3. Usoro mmemme nke HPC na nkwusioru:
Usoro nke HPC na-arụ ọrụ na nkwusioru gụnyere mmekọrịta ya na ma akụkụ ahụ siri ike na ụgbọ mmiri mmiri.Mgbe a gbasasịrị n'usoro mmiri mmiri, ụmụ irighiri ihe HPC na-etolite netwọk nwere akụkụ atọ site na njikọta hydrogen na njikọ polymer.Netwọk a na-ekpuchi akụkụ ahụ siri ike, na-egbochi agglomeration na idozi ha.A na-emetụta viscosity nke nkwusioru site na ntinye uche na ịdị arọ molecular nke HPC, yana njupụta dị elu na ịdị arọ molecular na-ebute mmụba viscosity.
4. Ngwa nke HPC na nkwusioru ọgwụ:
Hydroxypropylcellulose na-achọta ọtụtụ ojiji na nkwusioru ọgwụ dị iche iche, gụnyere:
a.Nkwusioru Ọnụ:
A na-arụkarị HPC n'ọrụ na nkwusioru ọnụ iji mepụta ọgwụ na-esighi ike maka nchịkwa ọnụ.Ọ na-eme ka solubility na bioavailability nke ihe ndị na-arụ ọrụ na-eme ka ọ dịkwuo mma ma na-ahụ na mgbasa nke otu na nhazi usoro nhazi.
b.Nkwusioru dị n'elu:
Na nkwusioru n'elu, HPC na-eje ozi dị ka onye na-akwụsịtụ maka ọgwụ na-adịghị mma ma ọ bụ nke na-adịghị mma emebere maka nnyefe dermal ma ọ bụ transdermal.Ọ na-enye viscosity na nhazi ahụ, na-eme ka mgbasa ya dịkwuo elu na nrapado na akpụkpọ ahụ.
c.Nkwusioru anya:
Maka nkwusioru anya, a na-eji HPC mee ka ụmụ irighiri ihe ndị a chụsasịrị kwụsasịa kwụsasịa ma jikwaa nkesa otu n'ime nhazi nhụta anya.Ngwongwo biocompatibility ya na ihe ndị na-adịghị ewe iwe na-eme ka ọ dị mma maka ojiji ophthalmic.
d.Nkwụsị ndị nne na nna:
Na nkwusioru nne na nna, ebe achọrọ usoro injectable, enwere ike iji HPC dị ka onye na-eme ka ọ kwụsie ike.Agbanyeghị, ojiji ya na usoro parenteral nwere oke n'ihi ntụle nchekwa na ndakọrịta na ụzọ ịgba ọgwụ.
5. Nkwubi okwu:
Hydroxypropylcellulose (HPC) bụ ngwa ahịa ọgwụ na-arụ ọrụ n'ọtụtụ ebe na usoro nkwusioru.Ikike ya ime ka ụmụ irighiri ihe gbasasịa kwụsasịa, gbanwee viscosity, melite nwụnye, na ịkwalite ndakọrịta na-eme ka ọ bụrụ ihe dị mkpa na nhazi nke nkwusioru maka ọnụ, n'akụkụ, ophthalmic, na ụzọ nchịkwa ndị ọzọ.Ịghọta ọrụ na usoro omume nke HPC na nkwusioru dị mkpa maka mmepe nke usoro ọgwụ dị irè ma kwụsie ike.Ka nyocha na teknụzụ na-aga n'ihu, ojiji nke HPC na nkwusioru ọgwụ nwere ike ịmalite, na-enye ohere ndị ọzọ maka imepụta ihe ọhụrụ na nkwalite na sistemụ nnyefe ọgwụ.
Oge nzipu: Mar-27-2024