HPMC (Hydroxypropyl Methyl Cellulose)naHPC (Hydroxypropyl Cellulose)bụ ma usoro cellulose, nke a na-ejikarị eme ihe na ọgwụ, nri, ihe owuwu na ụlọ ọrụ ịchọ mma. Ọ bụ ezie na ha abụọ yiri n'akụkụ ụfọdụ, o doro anya na ha dị iche na nhazi kemịkalụ, ihe anụ ahụ na nke kemịkal, solubility na mpaghara ngwa.
1. Chemical Ọdịdị na Njirimara
Emere HPMC site na methylation na hydroxypropylation nke cellulose eke, ma nwere methoxy (–OCH₃) na hydroxypropoxy (–OCH₂CHOHCH₃) dị n'ime molekul.
A na-enweta HPC site na hydroxypropylation nke cellulose, na isi ọrụ ya bụ hydroxypropoxy (-OCH₂CHOHCH₃), na-enweghị methoxy.
N'ihi na HPMC nwere otu methoxy ọzọ karịa HPC, HPMC dị ntakịrị karịa hydrophobic, ebe HPC bụ hydrophilic. Na mgbakwunye, ịdị arọ molekụla nke HPMC na-adịkarị elu, ebe ịdị arọ nke HPC nwere ike ịchịkwa n'ụzọ dị mfe karị, nke na-emetụta njirimara solubility na viscosity nke abụọ ahụ.
2. Mmiri solubility na njirimara solubility
HPMC na-agbaze n'ime mmiri oyi ka ọ bụrụ ngwọta colloidal translucent ma ọ bụ translucent, mana ọ naghị esiri ya ike na mmiri ọkụ. Ya mere, HPMC kwesịrị ka agbazerịrị ma ọ bụ gbasasịa site na iji ụzọ pụrụ iche na ụfọdụ ngwa.
HPC nwere ezigbo mmiri solubility ma nwee ike igbari na mmiri oyi na ụfọdụ ihe mgbaze organic, dị ka ethanol, methanol, wdg, ma nwee ezigbo ihe na-emepụta ihe na ihe nkiri.
HPMC nwere akụrụngwa thermogel. Mgbe okpomọkụ na-ebili, ihe ngwọta nwere ike kewapụ iche, ebe HPC anaghị emepụta thermogel, ya mere HPC nwere nkwụsi ike ka mma na gburugburu okpomọkụ dị elu.
3. Viscosity na rheological Njirimara
HPMC nwere viscosity dị elu ma a na-ejikarị ya eme ihe dị ka thickener, stabilizer na onye na-emepụta ihe nkiri. Njirimara rheological ya na ngwọta mmiri dị nso na mmiri mmiri pseudoplastic.
HPC nwere viscosity dị ala ma dabara adaba maka nhazi nke chọrọ ka mmiri dị mma, dị ka ọgwụ ọnụ na ihe mkpuchi.
4. Ngwa ngwa
N'ihi ọdịiche dị na akụrụngwa anụ ahụ na kemịkal dị n'etiti HPMC na HPC, ha na-arụ ọrụ dị iche iche na ụlọ ọrụ na ngwaahịa dị iche iche:
Ụlọ ọrụ ọgwụ
A na-ejikarị HPMC eme ihe dị ka ihe nchikota, ihe ntọhapụ na-adịgide adịgide, ihe mkpuchi ihe nkiri maka mbadamba ọgwụ, yana dịka akụkụ shei maka capsules oghere. Ihe onwunwe ya dị mma nke na-emepụta ihe nkiri na mmiri solubility na-eme ka ọ bụrụ ihe na-adọrọ mmasị maka nkwado nkwado na-adịgide adịgide.
A na-ejikarị HPC eme ihe dị ka ihe na-agbasa, ihe nkedo, solubilizer, na ihe bioadhesive maka mbadamba nkume, ma dị mma maka imeziwanye ike na bioavailability nke ọgwụ. Na mgbakwunye, HPC na-eji ọtụtụ ebe na-ekpo ọkụ gbazee extrusion technology karịa HPMC.
Ụlọ ọrụ nri
Enwere ike iji HPMC dị ka ihe na-ekpu nri, emulsifier, stabilizer, na emulsifier stabilizer maka ude na-abụghị mmiri ara ehi.
A na-ejikarị HPC eme ihe dị ka ihe na-esi nri, emulsifier, na ihe na-emeziwanye, ma dabara adaba maka nri ndị na-enweghị shuga na obere kalori.
Ihe ịchọ mma na nlekọta onwe onye
Enwere ike iji HPMC na ngwaahịa nlekọta anụ ahụ yana ncha dị ka emulsifier stabilizer.
HPC dabara adaba maka ngwaahịa nlekọta ntutu isi, mmiri mmiri na ngwaahịa nlekọta anya n'ihi ezigbo mmiri solubility na mmanu ya.
Ihe owuwu ụlọ
HPMC bụ akụkụ dị mkpa nke mkpuchi ihe owuwu ụlọ, ngwa agha, na ntụ ntụ, nke na-ekere òkè n'ịgba, njigide mmiri na ịkwalite nrachi.
A na-ejikarị HPC eme ihe na ụlọ ọrụ ihe owuwu, ma enwere ike iji ya mee ihe na mkpuchi mmiri na-edozi ahụ na nrapado.
5. Nchekwa gburugburu ebe obibi na nchekwa
Ma HPMC na HPC sitere na cellulose eke ma nwee ezigbo biodegradability na nchekwa. A na-ewere HPMC ka ọ bụrụ nke na-adịghị egbu egbu na nke na-adịghị ewe iwe, ebe a na-ejikwa HPC na nri na ọgwụ, na-emezu ihe nchekwa nchekwa nke FDA (US Food and Drug Administration) na ụkpụrụ mba ụwa ndị ọzọ.
6. Nhọrọ nhọrọ
Ọ bụrụ na achọrọ viscosity dị elu na ihe na-emepụta ihe nkiri, HPMC dabara adaba, dị ka mkpuchi mbadamba, mkpuchi ụlọ na ngwa ndị ọzọ.
Ọ bụrụ na achọrọ ka mma solubility na biocompatibility, HPC kwesịrị ekwesị, dị ka ọgwụ ọnụ, ihe mgbaze ọkụ na-ekpo ọkụ, wdg.
HPMCnaHPCbụ ma ihe dị mkpa cellulose, nke dị iche na nhazi kemịkalụ, solubility, na mpaghara ngwa. HPMC dabara adaba maka viscosity dị elu, ngwa na-ekpo ọkụ gel-akpụ dị ka mkpuchi mbadamba na ihe owuwu ụlọ, ebe HPC dabara adaba maka nkwadebe ọnụ, ihe ịchọ mma na ndị na-emezi nri n'ihi ezigbo mmiri solubility na obere viscosity. Dị ka mkpa dị iche iche si dị, ịhọrọ ihe kwesịrị ekwesị nwere ike imeziwanye arụmọrụ na nkwụsi ike nke ngwaahịa ahụ.
Oge nzipu: Mar-28-2025