hydroxypropyl methylcellulose (HPMC)bụ cellulose soluble mmiri nke a na-ejikarị eme ihe na nkwadebe ọgwụ, karịsịa n'ime nkwadebe siri ike ọnụ, nkwadebe mmiri ọnụ na nkwadebe anya. Dị ka ihe dị mkpa ọgwụ excipient, KimaCell®HPMC nwere multiple ọrụ, dị ka nrapado, thickener, nọgidere-wepụ akara gị n'ụlọnga, gelling gị n'ụlọnga, wdg Na ọgwụ preparations, HPMC nwere ike ọ bụghị nanị melite anụ ahụ Njirimara nke ọgwụ ọjọọ, kamakwa welie irè nke ọgwụ ọjọọ eme ihe, n'ihi ya, ọ na-enwe ọnọdụ dị mkpa na mmepe nke nkwadebe.
Njirimara nke HPMC
HPMC bụ mmiri-soluble ma ọ bụ ihe mgbaze-soluble cellulose ether nwetara site na-eji dochie akụkụ nke hydroxyl otu na cellulose molekul na methyl na hydroxypropyl otu. Ọ nwere ezigbo solubility na viscosity na mmiri, na ngwọta bụ transperent ma ọ bụ ubé turbid. HPMC nwere ezigbo nkwụsi ike na ihe ndị dị ka pH gburugburu ebe obibi na mgbanwe okpomọkụ, ya mere a na-eji ya eme ihe na nkwadebe ọgwụ.
HPMC nwere ezi biodegradability na eriri afọ tract, ezigbo biocompatibility na enweghị nsi, na nkwadebe ya adịghị mfe ịkpata mmeghachi omume nfụkasị, nke na-eme ka ọ dị nchebe iji na ọgwụ nkwadebe.
Ngwa ngwa nke HPMC na nkwadebe ọgwụ
Ngwa na nkwado ntọhapụ na-adịgide adịgide
A na-eji HPMC eme ihe n'ọtụtụ ebe na nkwadebe ntọhapụ, ọkachasị na nkwadebe siri ike ọnụ. HPMC nwere ike ijikwa ọnụego ntọhapụ nke ọgwụ site na nhazi netwọk gel ọ na-etolite. N'ime ọgwụ ndị na-agbaze mmiri, HPMC dị ka onye na-ahapụ ya nwere ike igbu oge ntọhapụ nke ọgwụ, si otú a na-agbatị ogologo oge nke ọgwụ ọjọọ, na-ebelata ọnụ ọgụgụ nke oge doses, na imeziwanye nnabata onye ọrịa.
Ụkpụrụ ngwa nke HPMC na nkwado ntọhapụ na-adịgide adịgide dabere na nrụnye ya na ihe ọzịza na mmiri. Mgbe mbadamba nkume ma ọ bụ capsules na-abanye n'ime eriri afọ, HPMC na-abanye na mmiri, na-amịkọrọ mmiri ma zaa iji mepụta akwa gel, nke nwere ike belata mgbasa na ntọhapụ nke ọgwụ. Enwere ike gbanwee ọnụego ntọhapụ nke ọgwụ dịka ụdị HPMC (dị ka ogo dị iche iche nke nnọchi nke hydroxypropyl na otu methyl) na itinye uche ya.
Ndị na-ekekọta ihe na ndị na-emepụta ihe nkiri
Na nkwadebe siri ike dị ka mbadamba nkume, capsules, na granules, HPMC dị ka ihe nkedo nwere ike imeziwanye ike na iguzosi ike n'ezi ihe nke nkwadebe. The bonding mmetụta nke HPMC na nkwadebe nwere ike ọ bụghị nanị na-eme ka ọgwụ ahụ irighiri ma ọ bụ powders jikọrọ ọnụ, ma na-amụba nkwụsi ike nke nkwadebe na ya solubility na ahu.
Dị ka onye na-emepụta ihe nkiri, HPMC nwere ike ịmepụta ihe nkiri otu ma na-ejikarị eme ihe maka mkpuchi ọgwụ. N'oge usoro mkpuchi nke nkwadebe, ihe nkiri KimaCell®HPMC nwere ike ọ bụghị nanị ichebe ọgwụ ahụ site na mmetụta nke gburugburu ebe obibi, kamakwa ịchịkwa ọnụego ntọhapụ nke ọgwụ ahụ. Dịka ọmụmaatụ, na nkwadebe nke mbadamba ihe mkpuchi nke enteric, HPMC dị ka ihe mkpuchi nwere ike igbochi ọgwụ ahụ ka a hapụ ya n'afọ ma hụ na a na-ahapụ ọgwụ ahụ n'ime eriri afọ.
Gelling gị n'ụlọnga na thickener
A na-eji HPMC eme ihe n'ọtụtụ ebe na nkwadebe anya na nkwadebe mmiri ndị ọzọ dị ka onye na-ahụ maka gelling. Na ọgwụ ophthalmic, HPMC nwere ike iji dị ka gelling akụrụngwa na artificial anya mmiri ka mma njide oge nke ọgwụ na mmanu mmetụta nke anya, na ibelata evaporation ọnụego nke anya tụlee. Ke adianade do, HPMC nwekwara ike ndim Njirimara, nke nwere ike dịkwuo viscosity nke nkwadebe na a ụfọdụ ịta, na adabara ndim dị iche iche mmiri mmiri preparations.
Na ọnụ mmiri mmiri nkwadebe, HPMC dị ka a thickener nwere ike melite nkwụsi ike nke nkwadebe, gbochie ọdịda na stratification nke ahụ, ma melite uto na ọdịdị.
Stabilizer maka nkwadebe mmiri mmiri ọnụ
HPMC nwere ike ịmepụta ngwọta colloidal kwụsiri ike na nkwadebe mmiri, si otú a na-eme ka nkwụsi ike nke nkwadebe ahụ dịkwuo elu. Ọ nwere ike melite solubility na ịdị n'otu nke ọgwụ na nkwadebe mmiri mmiri ma gbochie ọgwụ crystallization na ọdịda. Mgbe ị na-akwadebe ụfọdụ ọgwụ ndị na-emebi ngwa ngwa na ndị na-emebi emebi, mgbakwunye nke HPMC nwere ike ịgbatị ndụ ọgwụ ahụ nke ọma.
Dị ka emulsifier
A pụkwara iji HPMC mee ihe dị ka emulsifier iji mee ka emulsion kwụsie ike ma gbasaa ọgwụ ahụ mgbe ị na-akwadebe ọgwụ emulsion. Site n'ịchịkwa molekụla arọ na ịta nke HPMC, nkwụsi ike na rheological Njirimara nke emulsion nwere ike gbanwee ka ọ dị mma maka ụdị dị iche iche nke nkwadebe ọgwụ.
Uru ngwa nke HPMC
Akwa biocompatibility na nchekwa dị elu: HPMC, dị ka ihe na-emepụta cellulose eke, nwere ezigbo bioacompatibility, adịghị egbu egbu na nke na-adịghị ewe iwe, ya mere ọ dị mma maka iji nkwadebe ọgwụ.
Ọrụ njikwa mwepụta: HPMC nwere ike ijikwa ọnụego ntọhapụ nke ọgwụ site na akụrụngwa gelling ya, mee ka ọ dị ogologo oge nke ọgwụ, belata oge nchịkwa, ma melite nnabata onye ọrịa.
Ngwa dị ukwuu:HPMCenwere ike iji ya n'ụdị usoro ọgwụgwọ dị iche iche dị ka mbadamba nkume, capsules, granules, na nkwadebe mmiri mmiri, na-egbo mkpa nke nkwadebe ọgwụ dị iche iche.
Hydroxypropyl methylcellulose nwere uru ngwa dị mkpa na nkwadebe ọgwụ. Ọ bụghị naanị na a ga-eji ya dị ka onye na-ahapụ ya, nrapado, na onye na-emepụta ihe nkiri, kamakwa dị ka ihe na-eme ka ọkpụkpụ na stabilizer na nkwadebe mmiri mmiri. Ngwongwo anụ ahụ na kemịkal ya magburu onwe ya na-eme ka ọ bụrụ otu n'ime ihe ndị dị mkpa dị mkpa na ụlọ ọrụ ọgwụ, karịsịa na-egosi ikike dị ukwuu n'ịkwalite nkwụsi ike ọgwụ na ịchịkwa ọnụego ntọhapụ ọgwụ. Site na ọganihu teknụzụ ọgwụ na-aga n'ihu, atụmanya ngwa nke KimaCell®HPMC ga-aga n'ihu na-agbasawanye, na-enye nkwado maka nkwadebe ọgwụ dị mma ma dị irè karị.
Oge nzipu: Jan-27-2025