Ngwa nke ethyl cellulose na nkwadebe ọgwụ

Ethylcellulose (EC)bụ ogige polymer synthetic nke ọkara nke enwetara site na ethylation nke cellulose osisi eke. Nhazi molekụla a na-ahụkarị bụ nkeji glucose jikọtara ya na njikọ β-1,4-glycosidic. N'ihi ịdị mma ya dị mma nke biocompatibility, enweghị nsị, njikwa dị mma na ọtụtụ isi mmalite, ethyl cellulose na-ejikarị eme ihe na nkwadebe ọgwụ, karịsịa na ụlọ ọrụ ọgwụ.

1. Ihe ndị bụ isi nke ethyl cellulose

Ethyl cellulose nwere nnukwu biocompatibility ma nwee ike ịdị n'ime ahụ mmadụ ogologo oge na-emepụtaghị mmeghachi omume na-egbu egbu. Ọdịdị kemịkal ya na-enye ya ezigbo hydrophobicity, nkwụsi ike, acid na alkali nguzogide na ụfọdụ ihe ntọhapụ a na-achịkwa. Ke adianade do, ethyl cellulose bụ insoluble na mmiri, ma soluble na organic solvents dị ka ethanol, chloroform, acetone, wdg Ndị a Njirimara na-enye ya a dịgasị iche iche nke ngwa atụmanya na ọgwụ preparations.

2. Ngwa nke ethyl cellulose na nkwadebe ọgwụ

Ebe ntinye nke ethyl cellulose dị oke obosara, na-ekpuchi nkwadebe ọnụ, injections, nkwadebe mpụga na ọtụtụ akụkụ ndị ọzọ. Ndị na-esonụ bụ ọtụtụ isi ngwa nke ethyl cellulose na nkwadebe ọgwụ.

2.1 Nkwadebe mwepụta a na-achịkwa maka ọgwụ ọnụ

Ngwa ethyl cellulose a na-ejikarị eme ihe dị ka onye na-ewepụta ihe na-achịkwa, karịsịa na nkwadebe-mwepu maka ọgwụ ọnụ. Ọdịdị hydrophobic na njikwa nke ethyl cellulose na-eme ka ọ bụrụ ezigbo ihe eji ewepụta ọgwụ. N'ime nkwadebe ntọhapụ ọgwụ, ethyl cellulose nwere ike igbu oge ntọhapụ nke ọgwụ ahụ site n'ịme mkpuchi ihe nkiri, si otú ahụ nweta nzube nke ịgbatị mmetụta ọgwụ ahụ. Site n'ịgbanwe ihe dị arọ nke ethyl cellulose, ọkpụrụkpụ nke mkpuchi mkpuchi na ụdị ihe mgbaze ahọpụtara, enwere ike ịchịkwa ọnụego ntọhapụ na ntọhapụ nke ọgwụ ahụ.

A na-ejikarị ethyl cellulose eme ihe iji dozie mbadamba ụrọ siri ike na-ahapụ. A na-ekpuchi ọgwụ ahụ na fim ethyl cellulose. Usoro ntọhapụ ọgwụ nwere ike ịchịkwa site na ọzịza na solubility nke ihe nkiri ahụ na ntinye nke ihe mgbaze. Dị ka usoro dị iche iche na ọnọdụ usoro si dị, ethyl cellulose nwere ike ịchịkwa oge ntọhapụ nke ọgwụ ahụ n'ụzọ dị irè, belata ọnụ ọgụgụ nke oge dose, ma melite nnabata onye ọrịa.

2.2 mkpuchi ihe nkiri ọgwụ

N'ime nkwadebe ọgwụ, ethyl cellulose na-ejikarị eme ihe maka mkpuchi ihe nkiri, karịsịa na nkwadebe siri ike nke ọnụ dị ka mbadamba nkume, granules na capsules. Dị ka ihe mkpuchi ihe nkiri, ethyl cellulose nwere ezigbo ihe nkiri na-emepụta ihe nkiri, ịdị nro na ike arụ ọrụ, nke nwere ike inye nchebe maka ihe ndị na-emepụta ọgwụ na-egbochi ọgwụ ahụ ka ọ ghara imebi ma ọ bụ kpasuo eriri afọ na mpaghara gastric acid. N'otu oge ahụ, ihe nkiri ethyl cellulose nwere ike ijikwa ọnụego ntọhapụ nke ọgwụ ahụ, karịsịa site n'ịgbanwe nha ihe nkiri ahụ na iji ihe mgbaze dị iche iche, enwere ike nweta nkwụsị ntọhapụ dị iche iche.

Dị ka ihe mkpuchi, ethyl cellulose nwekwara ike imeziwanye uto nke ọgwụ ahụ, zere iwe ma ọ bụ ahụ erughị ala, ma mee ka nnabata ndị ọrịa dịkwuo elu.

2.3 Emulsion na micellar nkwadebe

N'ihi solubility ya na ọrụ elu, a na-ejikwa ethyl cellulose mee ihe na emulsions na nkwadebe micellar. N'ime nkwadebe nke emulsions, ethyl cellulose, dị ka emulsifier na stabilizer, nwere ike melite solubility nke ọgwụ ahụ n'ụzọ dị irè ma gbatịa ịdị irè nke ọgwụ ahụ. Karịsịa maka ụfọdụ ọgwụ ndị na-agbaze abụba, ethyl cellulose nwere ike inye aka gbasasịa ọgwụ ahụ n'ụzọ ziri ezi n'oge mmiri mmiri, belata oke mmiri ọgwụ na mmiri, ma melite bioavailability nke ọgwụ ahụ.

N'ime nkwadebe micellar, ethyl cellulose, dị ka onye na-eme ka ahụ sie ike, nwere ike ịmepụta usoro ọgwụ micellar kwụsiri ike, si otú ahụ na-emeziwanye ike na bioavailability nke ọgwụ ahụ n'ime ahụ, karịsịa maka ụfọdụ ọgwụ na-adịghị mma.

2.4 Nkwadebe ọgwụ dị n'elu

A na-ejikwa KimaCell®Ethyl cellulose mee ihe n'ọtụtụ ebe na nkwadebe ọgwụ n'elu, karịsịa na nkwadebe nke manu, ude, gels na nkwadebe ndị ọzọ. Dị ka ihe na-agba agba, ihe nkiri bụbu na onye na-eme ka ahụ sie ike, ethyl cellulose nwere ike imeziwanye mgbasawanye, nrapanye na ịdị n'otu nke ọgwụ ndị dị n'elu. N'ime nkwadebe dị n'elu dị ka ointments na creams, ethyl cellulose nwere ike imeziwanye viscosity na nkwụsi ike nke nkwadebe, na-ahụ na nkesa otu na ntọhapụ nke ọgwụ ahụ n'oge eji.

2.5 Sistemụ ebu ọgwụ

Ethyl cellulose nwekwara ike iji dị ka onye na-ebu ọgwụ, karịsịa na nkwadebe nke nanocarriers na microcarriers. Ethyl cellulose nwere ike ịmepụta ogige nwere mkpụrụ ndụ ọgwụ iji nye njikwa nnyefe ọgwụ ka mma. Na sistemu nanocarrier, enwere ike ịkwalite njirimara elu nke ethyl cellulose site na mgbanwe kemịkalụ ma ọ bụ ọgwụgwọ anụ ahụ iji kwalite n'ịkwado ọgwụ na njikwa njikwa ọnụego.

3. Uru na ihe ịma aka nke ethyl cellulose

Dị ka ihe mgbakwunye maka nkwadebe ọgwụ, KimaCell®ethyl cellulose nwere ọtụtụ uru. Ọ nwere ezigbo biocompatibility na biodegradability, nke nwere ike ibelata mmetụta ọjọọ na ahụ mmadụ; ọ nwere ike ịhazi ntọhapụ nke ọgwụ ọjọọ nke ọma ma melite mmetụta ọgwụgwọ ọgwụ; na mgbakwunye, teknụzụ nhazi nke ethyl cellulose tozuru oke, ejiri ya mee ihe n'ọtụtụ ebe, ọnụ ala dị ọnụ ala, yana dabara adaba maka mmepụta buru ibu. Otú ọ dị, ethyl cellulose na-echekwa ihe ịma aka ụfọdụ ihu. Dịka ọmụmaatụ, n'okpuru ụfọdụ ụkpụrụ pH dị oke ma ọ bụ ọnọdụ okpomọkụ dị elu, nkwụsi ike nke ethyl cellulose nwere ike ibelata, nke nwere ike imetụta mmetụta ngwa ya na gburugburu ebe dị iche iche.

Ethyl cellulosenwere atụmanya dị iche iche nke ngwa ngwa na nkwadebe ọgwụ, karịsịa n'ọhịa nke nkwadebe-mwepu na-achịkwa, mkpuchi ihe nkiri, emulsions, na nkwadebe n'elu. Ngwongwo anụ ahụ na kemịkalụ ya magburu onwe ya na-eme ka ọ bụrụ ihe dị mkpa dị mkpa na nkwadebe ọgwụ. Otú ọ dị, na ngwa ndị bara uru, ọ ka dị mkpa iji kwalite ma melite ụdị ọgwụ dị iche iche na ụdị nkwadebe iji merie ihe ịma aka ya na nkwụsi ike, njikwa ntọhapụ, wdg, ma na-emekwuwanye mmetụta ọgwụgwọ nke ọgwụ na nnabata onye ọrịa.