Hydroxypropyl methylcellulose (HPMC)yog ib qho tseem ceeb ntawm cov dej-soluble cellulose derivative nrog ntau yam kev siv, feem ntau hauv cov chaw muag tshuaj, zaub mov, tshuaj pleev ib ce, kev tsim kho thiab lwm yam kev lag luam. HPMC yog cov hmoov dawb los yog dawb, tsis qab thiab tsw ntxhiab uas yaj hauv dej thiab tuaj yeem tsim cov pob tshab, kua nplaum. Nws cov yam ntxwv tuaj yeem txheeb xyuas los ntawm ntau yam xws li cov qauv tshuaj, cov khoom siv lub cev, thiab daim ntawv thov.
1. Cov qauv tshuaj thiab kev npaj
HPMC yog cov khoom siv tshuaj tau los ntawm methylating thiab hydroxypropylating natural cellulose. Nws cov qauv suav nrog ob pawg ua haujlwm: ib qho yog methyl (-OCH₃) thiab lwm yam yog hydroxypropyl (-OCH₂CHOHCH₃). Kev taw qhia ntawm ob pawg no ua rau HPMC dej-soluble, nto active, thiab muaj kev sib txawv solubility, viscosity thiab lwm yam ntxwv.
Lub cev pob txha-based cellulose tseem khaws cia hauv cov qauv molecular ntawm HPMC, uas belongs rau ntuj polysaccharides thiab muaj biocompatibility zoo thiab biodegradability. Vim tias cov molecule muaj cov pab pawg ua haujlwm sib txawv, nws cov dej solubility, viscosity thiab stability tuaj yeem tswj tau raws li cov kev mob tshwm sim.
2. Solubility thiab viscosity
Ib qho tseem ceeb ntawm HPMC yog nws cov dej solubility zoo. HPMC nrog qhov sib txawv molecular hnyav thiab qib sib txawv ntawm kev hloov pauv muaj qhov sib txawv solubility thiab viscosity. HPMC tuaj yeem yaj sai sai hauv dej txias los tsim cov tshuaj colloidal ruaj khov, thiab tsis cuam tshuam los ntawm dej kub thiab dej pH.
Nyob ntawm seb hom thiab qib ntawm cov khoom hloov pauv, qhov viscosity ntawm HPMC tuaj yeem hloov kho ntau yam. Feem ntau hais lus, cov tshuaj aqueous ntawm HPMC muaj qee yam viscosity thiab tuaj yeem siv ua cov thickener, nplaum thiab stabilizer. Lub viscosity ntawm nws cov tshuaj aqueous tuaj yeem tswj tau los ntawm kev kho nws qhov hnyav molecular thiab qib ntawm kev hloov pauv, thiab cov viscosity ntau yog los ntawm ntau pua mus rau txhiab millipascals vib nas this (mPa s).
3. Thermal stability
HPMC muaj thermal stability zoo. Nyob rau hauv qhov kub thiab txias, cov qauv tshuaj thiab lub cev ntawm HPMC tseem nyob ruaj khov, thiab nws cov ntsiab lus melting feem ntau yog siab tshaj 200 ° C. Yog li ntawd, nws ua tau zoo nyob rau hauv qee qhov kev siv uas yuav tsum tau muaj qhov kub thiab txias. Tshwj xeeb tshaj yog nyob rau hauv cov khoom noj thiab tshuaj industries, HPMC tuaj yeem tiv taus ib puag ncig hnyav thaum siv los ua cov thickener lossis tswj cov khoom tso tawm.
4. Mechanical zog thiab gelation
HPMC cov tshuaj muaj lub zog txhua yam thiab elasticity, thiab tuaj yeem tsim cov qauv gel hauv qee yam mob. Hauv qee cov ntawv thov kev lag luam, HPMC feem ntau siv los tsim cov gels ruaj khov lossis cov yeeb yaj kiab, tshwj xeeb tshaj yog nyob rau hauv kev lag luam tshuaj, ntim khoom noj, tshuaj pleev ib ce, thiab lwm yam, rau kev tswj cov tshuaj tso tawm, thickening, stabilization thiab encapsulation ntawm cov khoom.
5. Biocompatibility thiab biodegradability
Txij li HPMC yog muab los ntawm ntuj cellulose, nws muaj biocompatibility zoo, yuav luag tsis muaj biotoxicity, thiab tuaj yeem degraded sai hauv lub cev. Qhov no feature ua rau nws ib tug nquag siv excipient nyob rau hauv kev lag luam kws tshuaj, tshwj xeeb tshaj yog rau cov tshuaj qhov ncauj thiab tswj kev tso tawm, uas yuav txhim khu lub bioavailability ntawm cov tshuaj los ntawm kev tswj tus nqi ntawm cov tshuaj.
6. Kev ua haujlwm saum npoo av
HPMC muaj qee qhov kev ua haujlwm saum npoo av, uas tuaj yeem txo qhov nro ntawm qhov kev daws teeb meem thiab txhim kho cov dispersibility thiab wettability ntawm cov kua. Nws yog tus yam ntxwv no uas ua rau HPMC dav siv hauv cov tshuaj pleev ib ce thiab cov khoom tu tus kheej, xws li thickeners, emulsifiers thiab stabilizers hauv tshuaj pleev ib ce, tshuaj zawv plaub hau, tshuaj zawv plaub hau thiab lwm yam khoom.
7. Cov khoom tsis-ionic
Tsis zoo li qee lwm cov khoom siv ntuj tsim polysaccharide, HPMC tsis yog-ionic. Nws tsis hnov mob nrog ions hauv cov tshuaj thiab yog li tsis cuam tshuam los ntawm kev hloov pauv hauv electrolyte concentration. Cov yam ntxwv no ua rau HPMC muaj txiaj ntsig zoo hauv qee qhov kev lag luam tshwj xeeb, tshwj xeeb tshaj yog thaum cov kev daws teeb meem aqueous lossis colloids xav tau kom ruaj khov rau lub sijhawm ntev, HPMC tuaj yeem ua kom ruaj khov thiab sib xws.
8. Kev siv ntau yam
Cov yam ntxwv ntawm HPMC no ua rau nws siv dav hauv ntau qhov chaw, feem ntau suav nrog cov hauv qab no:
Kev lag luam kws tshuaj: HPMC feem ntau yog siv los ua lub plhaub capsule rau cov tshuaj, cov khoom siv rau kev tso tawm cov tshuaj, cov nplaum nplaum, cov tshuaj thickener, thiab lwm yam.
Kev lag luam khoom noj khoom haus: HPMC yog dav siv hauv dej haus, jellies, ice creams, sauces thiab lwm yam khoom noj raws li ib tug thickener, stabilizer, emulsifier thiab gelling tus neeg sawv cev nyob rau hauv cov zaub mov kev lag luam, uas yuav txhim kho cov saj thiab kev ntxhib los mos ntawm cov khoom.
Cov khoom siv tshuaj pleev ib ce thiab kev tu tus kheej: Hauv cov tshuaj pleev ib ce, HPMC yog siv hauv cov tshuaj pleev ib ce, lub ntsej muag lub ntsej muag, tshuaj zawv plaub hau, cov khoom tu tawv nqaij thiab lwm yam khoom siv los ua lub luag haujlwm ntawm thickening, stabilization, emulsification thiab lwm yam haujlwm.
Kev tsim kho kev lag luam: HPMC feem ntau yog siv los ua cov thickener thiab dej-retaining tus neeg sawv cev hauv cov khoom siv hauv tsev. Cov ntawv siv feem ntau suav nrog cov cement mortar, pobzeb nplaum, thiab lwm yam, uas tuaj yeem txhim kho kev tsim kho thiab cov khoom ruaj khov.
Kev Ua Liaj Ua Teb: HPMC kuj tuaj yeem siv los ua kom ruaj khov thiab tuab hauv cov tshuaj tua kab los pab cov tshuaj faib sib npaug hauv cov av thiab txhim kho cov txiaj ntsig ntawm daim ntawv thov.
9. Kev tiv thaiv ib puag ncig thiab kev ruaj ntseg
Txij li lub ntsiab feem ntawmHPMClos ntawm ntuj cellulose thiab muaj biodegradability zoo, nws kuj muaj qee yam zoo hauv kev tiv thaiv ib puag ncig. Raws li cov khoom siv hluav taws xob ruaj khov, kev tsim khoom thiab kev siv HPMC yuav tsis ua rau lub nra hnyav rau ib puag ncig.
Hydroxypropyl methylcellulose (HPMC) muaj ntau yam zoo heev, xws li dej solubility zoo, viscosity tswj, thermal stability, biocompatibility, thiab lwm yam. Nws yog dav siv nyob rau hauv ntau industries xws li tshuaj, khoom noj khoom haus, tshuaj pleev ib ce, thiab kev tsim kho. Nrog nws cov khoom tsis-ionic, kho lub cev thiab tshuaj lom neeg, thiab kev phooj ywg ib puag ncig, HPMC tau suav tias yog cov khoom siv polymer zoo heev. Nyob rau yav tom ntej kev lag luam thiab kev tsim kho thev naus laus zis, HPMC tseem muaj kev tshawb fawb dav dav thiab kev siv peev xwm.
Post lub sij hawm: Dec-13-2024