Hydroxypropyl methylcellulose (HPMC)yog cov dej-soluble cellulose derivative dav siv nyob rau hauv kev npaj tshuaj, tshwj xeeb tshaj yog nyob rau hauv lub qhov ncauj khoom npaj, lub qhov ncauj kua npaj thiab ophthalmic npaj. Raws li ib qho tseem ceeb tshuaj excipient, KimaCell®HPMC muaj ntau lub zog, xws li nplaum, thickener, sustained-tso tswj tus neeg saib xyuas, gelling agent, thiab lwm yam. Hauv kev npaj tshuaj, HPMC tsis tuaj yeem txhim kho lub cev ntawm cov tshuaj, tab sis kuj txhim kho cov txiaj ntsig ntawm cov tshuaj, yog li nws muaj txoj haujlwm tseem ceeb hauv kev npaj cov tshuaj.
Cov cuab yeej ntawm HPMC
HPMC yog ib qho dej-soluble lossis hnyav-soluble cellulose ether tau los ntawm kev hloov ib feem ntawm hydroxyl pawg hauv cellulose molecules nrog methyl thiab hydroxypropyl pawg. Nws muaj zoo solubility thiab viscosity nyob rau hauv dej, thiab cov tshuaj yog pob tshab los yog me ntsis turbid. HPMC muaj kev ruaj ntseg zoo rau yam xws li ib puag ncig pH thiab kub hloov pauv, yog li nws tau siv dav hauv kev npaj tshuaj.
HPMC muaj biodegradability zoo nyob rau hauv lub plab zom mov, zoo biocompatibility thiab non-toxicity, thiab nws cov kev npaj tsis yooj yim rau kev ua xua, uas ua rau nws muaj kev nyab xeeb rau siv nyob rau hauv cov tshuaj npaj.
Cov ntawv thov tseem ceeb ntawm HPMC hauv kev npaj tshuaj
Daim ntawv thov nyob rau hauv sustained-tso npaj
HPMC yog dav siv nyob rau hauv sustained-tso npaj, tshwj xeeb tshaj yog nyob rau hauv lub qhov ncauj khoom npaj. HPMC tuaj yeem tswj hwm tus nqi tso tawm ntawm cov tshuaj los ntawm gel network qauv nws tsim. Hauv cov tshuaj uas muaj dej-soluble, HPMC ua tus neeg sawv cev tso tawm tuaj yeem ncua sijhawm tso tawm cov tshuaj, yog li ua kom lub sijhawm ntev ntawm kev siv tshuaj, txo cov sijhawm siv tshuaj, thiab txhim kho kev ua raws li tus neeg mob.
Lub hauv paus ntsiab lus ntawm kev thov ntawm HPMC hauv kev npaj tso tawm-tso tawm yog nyob ntawm nws cov dej solubility thiab o hauv dej. Thaum cov ntsiav tshuaj lossis cov tshuaj ntsiav nkag mus rau hauv lub plab zom mov, HPMC los rau hauv kev sib cuag nrog dej, nqus dej thiab swells los ua ib txheej gel, uas tuaj yeem ua rau qeeb qeeb thiab tso tawm cov tshuaj. Tus nqi tso tawm ntawm cov tshuaj tuaj yeem hloov kho raws li hom HPMC (xws li qib sib txawv ntawm kev hloov pauv ntawm hydroxypropyl thiab methyl pawg) thiab nws cov concentration.
Binders thiab film-forming agents
Nyob rau hauv cov khoom npaj xws li ntsiav tshuaj, tshuaj ntsiav, thiab granules, HPMC raws li ib tug binder tuaj yeem txhim kho qhov hardness thiab kev ncaj ncees ntawm kev npaj. Cov txiaj ntsig kev sib raug zoo ntawm HPMC hauv kev npaj tuaj yeem tsis tsuas yog ua rau cov khoom siv tshuaj lossis cov hmoov sib xyaw ua ke, tab sis kuj ua rau kom muaj kev ruaj ntseg ntawm kev npaj thiab nws cov solubility hauv lub cev.
Raws li tus neeg sawv cev ua yeeb yaj kiab, HPMC tuaj yeem tsim cov yeeb yaj kiab tsis sib xws thiab feem ntau siv rau txheej tshuaj. Thaum lub sij hawm txheej txheej txheej txheem ntawm kev npaj, KimaCell®HPMC zaj duab xis tuaj yeem tsis tsuas yog tiv thaiv cov tshuaj los ntawm kev cuam tshuam ntawm ib puag ncig sab nraud, tab sis kuj tswj tau qhov tso tawm ntawm cov tshuaj. Piv txwv li, nyob rau hauv kev npaj ntawm enteric-coated ntsiav tshuaj, HPMC raws li ib tug txheej txheej yuav tiv thaiv tau cov tshuaj nyob rau hauv lub plab thiab xyuas kom meej tias cov tshuaj tso tawm nyob rau hauv txoj hnyuv.
Gelling tus neeg sawv cev thiab thickener
HPMC yog dav siv nyob rau hauv ophthalmic npaj thiab lwm yam kua npaj ua ib tug gelling neeg sawv cev. Hauv cov tshuaj ophthalmic, HPMC tuaj yeem siv los ua cov tshuaj tiv thaiv gelling hauv cov kua muag dag los txhim kho lub sijhawm tuav ntawm cov tshuaj thiab cov nyhuv lubrication ntawm lub qhov muag, thiab txo qhov evaporation ntawm qhov muag tee. Tsis tas li ntawd, HPMC kuj tseem muaj zog thickening zog, uas tuaj yeem ua rau kom cov viscosity ntawm qhov kev npaj ntawm ib qho concentration, thiab yog tsim rau thickening ntau yam kua npaj.
Hauv kev npaj ua kua hauv qhov ncauj, HPMC ua cov thickener tuaj yeem txhim kho kev ruaj ntseg ntawm kev npaj, tiv thaiv cov nag lossis daus thiab stratification ntawm cov khoom, thiab txhim kho qhov saj thiab tsos.
Stabilizer rau kev npaj kua hauv qhov ncauj
HPMC tuaj yeem tsim cov tshuaj colloidal ruaj khov hauv kev npaj ua kua, yog li txhim kho qhov ruaj khov ntawm kev npaj. Nws tuaj yeem txhim kho cov solubility thiab uniformity ntawm cov tshuaj hauv cov kua npaj thiab tiv thaiv cov tshuaj crystallization thiab nag lossis daus. Thaum npaj qee cov tshuaj uas yooj yim decomposed thiab perishable, qhov sib ntxiv ntawm HPMC tuaj yeem ua kom ntev lub neej ntawm cov tshuaj.
Raws li emulsifier
HPMC kuj tuaj yeem siv los ua emulsifier kom ruaj khov emulsion thiab tawg cov tshuaj thaum npaj cov tshuaj emulsion. Los ntawm kev tswj qhov hnyav molecular thiab concentration ntawm HPMC, qhov ruaj khov thiab rheological zog ntawm emulsion tuaj yeem hloov kho kom haum rau ntau hom tshuaj npaj.
Kev siv qhov zoo ntawm HPMC
High biocompatibility thiab kev nyab xeeb: HPMC, raws li ib tug natural cellulose derivative, muaj biocompatibility zoo, yog tsis muaj tshuaj lom thiab tsis ua rau khaus, thiab yog li ntawd heev haum rau siv nyob rau hauv cov tshuaj npaj.
Kev tswj hwm kev tso tawm: HPMC tuaj yeem tswj hwm tus nqi tso tawm ntawm cov tshuaj los ntawm nws cov khoom gelling, ua kom ntev ntawm cov tshuaj, txo qhov zaus ntawm kev tswj hwm, thiab txhim kho kev ua raws li tus neeg mob.
Kev siv ntau yam:HPMCtuaj yeem siv rau ntau hom tshuaj xws li ntsiav tshuaj, tshuaj ntsiav, granules, thiab kua tshuaj npaj, ua tau raws li qhov xav tau ntawm kev npaj tshuaj sib txawv.
Hydroxypropyl methylcellulose muaj cov txiaj ntsig tseem ceeb hauv kev npaj tshuaj. Nws tuaj yeem tsis tsuas yog siv los ua tus neeg saib xyuas kev tso tawm, cov nplaum, thiab cov neeg ua yeeb yaj kiab, tab sis kuj yog cov thickener thiab stabilizer hauv cov kua npaj. Nws lub cev zoo heev thiab tshuaj lom neeg ua rau nws yog ib qho tseem ceeb ntawm excipients nyob rau hauv kev lag luam kws tshuaj, tshwj xeeb tshaj yog qhia tau hais tias muaj peev xwm nyob rau hauv kev txhim kho tshuaj stability thiab tswj cov tshuaj tso tawm tus nqi. Nrog rau kev nce qib ntawm kev siv tshuaj tsis tu ncua, daim ntawv thov kev cia siab ntawm KimaCell®HPMC yuav txuas ntxiv mus ntxiv, muab kev txhawb nqa rau kev npaj tshuaj zoo dua thiab muaj txiaj ntsig zoo dua.
Post lub sij hawm: Jan-27-2025