I-HPMC (i-Hydroxypropyl Methylcellulose) ii-capsules, ezaziwa njengee-capsules zemifuno, zisetyenziswa kakhulu kumachiza, kwi-nutraceuticals, kunye nezongezo zokutya. Ezi capsules zenziwe ikakhulu yi-HPMC, i-semi-synthetic polymer ephuma kwi-cellulose. Iipilisi ze-HPMC zenzelwe ukunyibilika kwi-gastrointestinal (GI) tract, iququzelele ukukhululwa kunye nokufunxa iziqulatho ezifakwe kwi-encapsulated.
kubalulekile ukuqonda ukwakheka kunye nolwakhiwo lwee-capsules ze-HPMC. I-HPMC yi-polymer ye-hydrophilic, oku kuthetha ukuba inobudlelwane kwiimolekyuli zamanzi. Olu phawu luchaphazela ukuziphatha kokuchithwa kwee-capsules ze-HPMC. Xa ibonakaliswe kwiindawo ezinamanzi, ezifana nolwelo olukhoyo kwiphecana le-GI, i-HPMC iwafunxa ngokulula amanzi, okukhokelela ekudumbeni nasekupheliseni iqokobhe le-capsule.
Ukunyibilika kweekhepsuli zeHPMC emanzini kuxhomekeke kwizinto ezininzi:
IBanga le-HPMC: Kukho amabakala ahlukeneyo e-HPMC, ngalinye linamazinga ahlukeneyo okunyibilika. Ngokubanzi, i-HPMC ye-pharmaceutical-grade esetyenziselwa ukuveliswa kwe-capsule yenzelwe ukunyibilika ngokukhawuleza kwiindawo ezinamanzi. Nangona kunjalo, ukunyibilika okuchanekileyo kunokwahluka ngokusekelwe kwinqanaba elithile kunye noqulunqo.
Ukubunjwa kweCapsule: Iipilisi ze-HPMC zinokuqulatha izinto ezincedisayo ezongezelelweyo okanye iingubo zokuguqula iimpawu zabo zokuchithwa. Ezi zongezo zinokuchaphazela ukunyibilika kwee-capsules emanzini. Umzekelo, ezinye izinto zokwaleka zinokulibazisa ukupheliswa ukuze kuphunyezwe iiprofayili zokukhululwa ezilungisiweyo.
Ukutyeba kweCapsule: Ubuninzi begobolondo ye-capsule inokuchaphazela izinga lokuchithwa kwayo. Amaqokobhe atyebileyo asenokuthatha ixesha elide ukunyibilika xa kuthelekiswa naqatha, njengoko enika ukuxhathisa okukhulu ekungeneni kwamanzi.
Imiba yokusingqongileyo: Izinto ezifana ne-pH kunye nobushushu zinokuchaphazela ukunyibilika kwee-capsules ze-HPMC emanzini. I-pH ye-dissolution medium ilinganisa iimeko ze-GI tract, apho ii-capsules ze-HPMC zenzelwe ukunyibilika. Amaqondo obushushu aphezulu anokuyikhawulezisa inkqubo yonyibiliko, kanti amaqondo obushushu asezantsi anokuyithothisa.
Ubukho bezinye izinto: Ubukho bezinye izinto kwindawo yonyibiliko, njengeetyuwa, ii-enzymes, okanye i-surfactants, zinokusebenzisana ne-HPMC kwaye ziphembelele ukuziphatha kwayo kokunyibilika.
Iipilisi ze-HPMC ziyilelwe ukuba zinyibilike emanzini, ngakumbi kwindawo enamanzi kwiphecana le-GI. Nangona kunjalo, ukunyibilika okuchanekileyo kunokwahluka ngokuxhomekeke kwizinto ezifana nebakala le-HPMC, ukwakheka kwe-capsule, ubukhulu, iimeko zokusingqongileyo, kunye nobukho bezinye izinto. Ii-capsules ze-HPMC zodidi loKhemesti ziye zaqulunqwa ngokubanzi ukuze kuqinisekiswe ukupheliswa ngokukhawuleza kokuhanjiswa kwechiza okusebenzayo kunye nokufunxa.
Ixesha lokuposa: May-11-2024